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- W305764390 abstract "To study the protective effects of the extract of Camellia japonica L.on learning-memory dysfunction induced by ischemia-reperfusion in mice and its relationship with inflammation and blood-brain barrier damage,on day 7 after drug treatment,repeated cerebral ischemia-reperfusion was induced by fastening bilateral common carotid artery.The 7th day following surgery,learning-memory was measured using Morris water maze.The activity of MPO and the content of EB were then measured by Uv-photospectrometer analysis system.Meanwhile,the content of water were detected.The results showed that,ischemia-reperfusion impaired learning-memory(P0.05 and P0.01),and increased the activity of MPO and the content of EB and water in mice (P0.01).It was found that the extract of Camellia japonica L.can make blood-brain barrier less serious and ameliorate neutrophil infiltration,remarkably decreasing the content of EB(P0.01),water(P0.05),and the activity of MPO(P0.05 and P0.01) when compared to the model group,finally dramatically improve the ability of learning-memory after ischemia-reperfusion(P0.05,P0.01).The extract of Camellia japonica L.showed an improvement effect on the memory impairment in mice induced by ischemia/reperfusion.Improvement of the anti-blood-brain-barrier-damage and anti-inflammation in brain may be involved in." @default.
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- W305764390 date "2008-01-01" @default.
- W305764390 modified "2023-09-26" @default.
- W305764390 title "The protective effects of the extract of Camellia japonica L. on learning-memory dysfunction induced by ischemia-reperfusion in mice and its relationship with inflammation and blood-brain barrier damage." @default.
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