FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3057890797> ?p ?o ?g. }

• W3057890797 endingPage "617" @default.
• W3057890797 startingPage "617" @default.
• W3057890797 abstract "Estrogen (ER) and progesterone (PgR) receptors and HER2 are crucial in the assessment of breast cancer specimens due to their prognostic and predictive significance. Single hormone receptor-positive breast cancers are less common and their clinical course is less favorable than ER(+)/PgR(+) tumors. Their molecular features, especially microRNA (miRNA) profiles, have not been investigated to date. Tumor specimens from 36 chemonaive breast cancer patients with known ER and PgR status (18 ER(+)/PgR(−) and 18 ER(−)/PgR(+) cases) were enrolled to the study. The expression of 829 miRNAs was evaluated with nCounter Human v3 miRNA expression Assay (NanoString). miRNAs differentiating between ER/PgR/HER2 phenotypes were selected based on fold change (FC) calculated for the mean normalized counts of each probe in compared groups. The differences were estimated with Student’s t-test or Two-Way ANOVA (considering also the HER2 status). The results were validated using The Cancer Genome Atlas (TCGA) dataset. Following quality control of raw data, fourcases were excluded due to low sample quality, leaving 14 ER(+)/PgR(−) and 18 ER(−)/PgR(+) cases. After correction for multiple comparisons, we did not find miRNA signature differentiating between ER(−)/PgR(+) and ER(+)/PgR(−) breast cancers. However, a trend for differing expression (p-value ≤ 0.05; FDR > 0.2; ANOVA) in eight miRNAs was observed. The ER(+)/PgR(−) group demonstrated elevated levels of four miRNAs—miR-30a-5p, miR-29c-3p, miR-141-3p and miR-423-5p—while the ER(−)/PgR(+) tumors were enriched in another four miRNAs—miR-514b-5p, miR-424-5p, miR-495-3p, and miR-92a-3p. For one of the miRNAs—miR-29c-3p—the association with the ER(+)/PgR(−) phenotype was confirmed in the TCGA cohort (p-value = 0.024; t-test). HER2 amplification/overexpression in the NanoString cohort was related to significant differences observed in 33 miRNA expression levels (FDR ≤ 0.2; ANOVA). The association with HER2 status was confirmed in the TCGA cohort for four miRNAs (miR-1180-3p, miR-223-3p, miR-30d-5p, and miR-195-5p). The main differences in miRNA expression amongst single hormone receptor-positive tumors were identified according to their HER2 status. However, ER(+)/PgR(−) cases tended to express higher levels of miRNAs associated with ER-positivity (miR-30a-5p, miR-29c-3p, miR-141-3p), whereas ER(−)/PgR(+) cancers showed elevated levels of miRNAs characteristic for double- and triple-negative tumors (miR-92a-3p, miR-424-5p). Further studies are necessary to comprehensively analyze miRNA signatures characteristic of ER(−)/PgR(+) and ER(+)/PgR(−) tumors." @default.
• W3057890797 created "2020-08-24" @default.
• W3057890797 creator A5016335263 @default.
• W3057890797 creator A5017484722 @default.
• W3057890797 creator A5028758825 @default.
• W3057890797 creator A5034674916 @default.
• W3057890797 creator A5036264969 @default.
• W3057890797 creator A5042237464 @default.
• W3057890797 creator A5049601783 @default.
• W3057890797 creator A5050442240 @default.
• W3057890797 creator A5050850130 @default.
• W3057890797 creator A5052856867 @default.
• W3057890797 creator A5057040630 @default.
• W3057890797 creator A5057317181 @default.
• W3057890797 creator A5059141227 @default.
• W3057890797 creator A5066950401 @default.
• W3057890797 creator A5067868368 @default.
• W3057890797 creator A5080154093 @default.
• W3057890797 creator A5090510277 @default.
• W3057890797 date "2020-08-20" @default.
• W3057890797 modified "2023-09-30" @default.
• W3057890797 title "microRNA Expression Profile in Single Hormone Receptor-Positive Breast Cancers Is Mainly Dependent on HER2 Status—A Pilot Study" @default.
• W3057890797 cites W1528850234 @default.
• W3057890797 cites W1648301895 @default.
• W3057890797 cites W1811830995 @default.
• W3057890797 cites W1908864745 @default.
• W3057890797 cites W1964496783 @default.
• W3057890797 cites W1980982863 @default.
• W3057890797 cites W2031843272 @default.
• W3057890797 cites W2044702943 @default.
• W3057890797 cites W2063874882 @default.
• W3057890797 cites W2066550621 @default.
• W3057890797 cites W2070353264 @default.
• W3057890797 cites W2081427413 @default.
• W3057890797 cites W2096283457 @default.
• W3057890797 cites W2097951173 @default.
• W3057890797 cites W2109032096 @default.
• W3057890797 cites W2112798314 @default.
• W3057890797 cites W2126607607 @default.
• W3057890797 cites W2133465414 @default.
• W3057890797 cites W2137999492 @default.
• W3057890797 cites W2142221925 @default.
• W3057890797 cites W2158217645 @default.
• W3057890797 cites W2310580441 @default.
• W3057890797 cites W2341117915 @default.
• W3057890797 cites W2411621843 @default.
• W3057890797 cites W2560367415 @default.
• W3057890797 cites W2589704771 @default.
• W3057890797 cites W2599116602 @default.
• W3057890797 cites W2605111841 @default.
• W3057890797 cites W2736520162 @default.
• W3057890797 cites W2803725301 @default.
• W3057890797 cites W2916657773 @default.
• W3057890797 cites W2920362050 @default.
• W3057890797 cites W2945870094 @default.
• W3057890797 cites W2950382962 @default.
• W3057890797 cites W2952528394 @default.
• W3057890797 cites W2978693295 @default.
• W3057890797 cites W2991757371 @default.
• W3057890797 cites W2995328856 @default.
• W3057890797 cites W3031731126 @default.
• W3057890797 cites W3122049309 @default.
• W3057890797 doi "https://doi.org/10.3390/diagnostics10090617" @default.
• W3057890797 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7555149" @default.
• W3057890797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32825530" @default.
• W3057890797 hasPublicationYear "2020" @default.
• W3057890797 type Work @default.
• W3057890797 sameAs 3057890797 @default.
• W3057890797 citedByCount "6" @default.
• W3057890797 countsByYear W30578907972021 @default.
• W3057890797 countsByYear W30578907972022 @default.
• W3057890797 countsByYear W30578907972023 @default.
• W3057890797 crossrefType "journal-article" @default.
• W3057890797 hasAuthorship W3057890797A5016335263 @default.
• W3057890797 hasAuthorship W3057890797A5017484722 @default.
• W3057890797 hasAuthorship W3057890797A5028758825 @default.
• W3057890797 hasAuthorship W3057890797A5034674916 @default.
• W3057890797 hasAuthorship W3057890797A5036264969 @default.
• W3057890797 hasAuthorship W3057890797A5042237464 @default.
• W3057890797 hasAuthorship W3057890797A5049601783 @default.
• W3057890797 hasAuthorship W3057890797A5050442240 @default.
• W3057890797 hasAuthorship W3057890797A5050850130 @default.
• W3057890797 hasAuthorship W3057890797A5052856867 @default.
• W3057890797 hasAuthorship W3057890797A5057040630 @default.
• W3057890797 hasAuthorship W3057890797A5057317181 @default.
• W3057890797 hasAuthorship W3057890797A5059141227 @default.
• W3057890797 hasAuthorship W3057890797A5066950401 @default.
• W3057890797 hasAuthorship W3057890797A5067868368 @default.
• W3057890797 hasAuthorship W3057890797A5080154093 @default.
• W3057890797 hasAuthorship W3057890797A5090510277 @default.
• W3057890797 hasBestOaLocation W30578907971 @default.
• W3057890797 hasConcept C104317684 @default.
• W3057890797 hasConcept C121608353 @default.
• W3057890797 hasConcept C126322002 @default.
• W3057890797 hasConcept C134018914 @default.
• W3057890797 hasConcept C143998085 @default.
• W3057890797 hasConcept C145059251 @default.
• W3057890797 hasConcept C2777164284 @default.

• next