FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3058021228> ?p ?o ?g. }

• W3058021228 abstract "Abstract Background Early mechanisms underlying the progressive tissue death and the regenerative capability of burn wounds are understudied in human skin. A clinically relevant, reproducible model for human burn wound healing is needed to elucidate the early changes in the human burn wound environment. This study reports a reproducible contact burn model on human skin that explores the extent of tissue injury and healing over time, and defines the inter-individual variability in human skin to enable use in mechanistic studies on burn wound progression and healing. Methods Using a customized burn device, contact burns of various depths were created on human skin by two operators and were evaluated for histologic depth by three raters to determine reproducibility. Early burn wound progression and wound healing were also evaluated histologically after the thermally injured human skin was cultured ex vivo for up to 14 days. Results Burn depths were reproducibly generated on human skin in a temperature- or time-dependent manner. No significant difference in operator-created or rater-determined depth was observed within each patient sample. However, significant inter-individual variation was identified in burn depth in ten patient samples. Burn-injured ex vivo human skin placed into culture demonstrated differential progression of cell death and collagen denaturation for high and low temperature contact burns, while re-epithelialization was observed in superficial burn wounds over a period of 14 days. Conclusion This model represents an invaluable tool to evaluate the inter-individual variability in early burn wound progression and wound healing to complement current animal models and enhance the translation of preclinical research to improvements in patient care." @default.
• W3058021228 created "2020-08-24" @default.
• W3058021228 creator A5000664850 @default.
• W3058021228 creator A5010413374 @default.
• W3058021228 creator A5011471044 @default.
• W3058021228 creator A5017691946 @default.
• W3058021228 creator A5046861121 @default.
• W3058021228 creator A5054108202 @default.
• W3058021228 creator A5077155065 @default.
• W3058021228 date "2020-08-18" @default.
• W3058021228 modified "2023-10-14" @default.
• W3058021228 title "Modelling early thermal injury using an ex vivo human skin model of contact burns" @default.
• W3058021228 cites W1500628783 @default.
• W3058021228 cites W173811556 @default.
• W3058021228 cites W1925741418 @default.
• W3058021228 cites W1973435092 @default.
• W3058021228 cites W1974799059 @default.
• W3058021228 cites W1980393509 @default.
• W3058021228 cites W1981224048 @default.
• W3058021228 cites W1981462581 @default.
• W3058021228 cites W1982974441 @default.
• W3058021228 cites W1985470834 @default.
• W3058021228 cites W1985706484 @default.
• W3058021228 cites W1988871156 @default.
• W3058021228 cites W1991655301 @default.
• W3058021228 cites W2011656757 @default.
• W3058021228 cites W2013960827 @default.
• W3058021228 cites W2049834169 @default.
• W3058021228 cites W2053795936 @default.
• W3058021228 cites W2058232316 @default.
• W3058021228 cites W2060049869 @default.
• W3058021228 cites W2062420445 @default.
• W3058021228 cites W2096774137 @default.
• W3058021228 cites W2097156023 @default.
• W3058021228 cites W2124041753 @default.
• W3058021228 cites W2234263126 @default.
• W3058021228 cites W2251164277 @default.
• W3058021228 cites W2281061480 @default.
• W3058021228 cites W2328257281 @default.
• W3058021228 cites W2471425358 @default.
• W3058021228 cites W2490398605 @default.
• W3058021228 cites W2507954495 @default.
• W3058021228 cites W2678532755 @default.
• W3058021228 cites W2780153520 @default.
• W3058021228 cites W2896211000 @default.
• W3058021228 cites W2906231105 @default.
• W3058021228 cites W2949357154 @default.
• W3058021228 doi "https://doi.org/10.1101/2020.08.18.254458" @default.
• W3058021228 hasPublicationYear "2020" @default.
• W3058021228 type Work @default.
• W3058021228 sameAs 3058021228 @default.
• W3058021228 citedByCount "3" @default.
• W3058021228 countsByYear W30580212282022 @default.
• W3058021228 countsByYear W30580212282023 @default.
• W3058021228 crossrefType "posted-content" @default.
• W3058021228 hasAuthorship W3058021228A5000664850 @default.
• W3058021228 hasAuthorship W3058021228A5010413374 @default.
• W3058021228 hasAuthorship W3058021228A5011471044 @default.
• W3058021228 hasAuthorship W3058021228A5017691946 @default.
• W3058021228 hasAuthorship W3058021228A5046861121 @default.
• W3058021228 hasAuthorship W3058021228A5054108202 @default.
• W3058021228 hasAuthorship W3058021228A5077155065 @default.
• W3058021228 hasBestOaLocation W30580212281 @default.
• W3058021228 hasConcept C126322002 @default.
• W3058021228 hasConcept C136229726 @default.
• W3058021228 hasConcept C141071460 @default.
• W3058021228 hasConcept C142724271 @default.
• W3058021228 hasConcept C150903083 @default.
• W3058021228 hasConcept C16005928 @default.
• W3058021228 hasConcept C175933922 @default.
• W3058021228 hasConcept C207001950 @default.
• W3058021228 hasConcept C26291073 @default.
• W3058021228 hasConcept C2777459323 @default.
• W3058021228 hasConcept C2778117688 @default.
• W3058021228 hasConcept C2780269544 @default.
• W3058021228 hasConcept C2781257246 @default.
• W3058021228 hasConcept C2993242423 @default.
• W3058021228 hasConcept C3017647366 @default.
• W3058021228 hasConcept C3019879682 @default.
• W3058021228 hasConcept C54355233 @default.
• W3058021228 hasConcept C71924100 @default.
• W3058021228 hasConcept C86803240 @default.
• W3058021228 hasConceptScore W3058021228C126322002 @default.
• W3058021228 hasConceptScore W3058021228C136229726 @default.
• W3058021228 hasConceptScore W3058021228C141071460 @default.
• W3058021228 hasConceptScore W3058021228C142724271 @default.
• W3058021228 hasConceptScore W3058021228C150903083 @default.
• W3058021228 hasConceptScore W3058021228C16005928 @default.
• W3058021228 hasConceptScore W3058021228C175933922 @default.
• W3058021228 hasConceptScore W3058021228C207001950 @default.
• W3058021228 hasConceptScore W3058021228C26291073 @default.
• W3058021228 hasConceptScore W3058021228C2777459323 @default.
• W3058021228 hasConceptScore W3058021228C2778117688 @default.
• W3058021228 hasConceptScore W3058021228C2780269544 @default.
• W3058021228 hasConceptScore W3058021228C2781257246 @default.
• W3058021228 hasConceptScore W3058021228C2993242423 @default.
• W3058021228 hasConceptScore W3058021228C3017647366 @default.
• W3058021228 hasConceptScore W3058021228C3019879682 @default.
• W3058021228 hasConceptScore W3058021228C54355233 @default.
• W3058021228 hasConceptScore W3058021228C71924100 @default.

• next