Matches in SemOpenAlex for { <https://semopenalex.org/work/W305851178> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W305851178 endingPage "406" @default.
- W305851178 startingPage "403" @default.
- W305851178 abstract "This chapter presents a comparison of the interaction of cumene hydroperoxide and hydrogen peroxide with liver microsomal cytochromes. Organic peroxides such as cumene hydroperoxide can react with the ferric form of microsomal cytochrome P-450 to catalyze the oxidative metabolism of a variety of different substrates. In contrast, hydrogen peroxide addition to liver microsomes results in the oxidative transformation of only a limited type of substrate, notably a compound capable of undergoing N-dealkylation reactions. The differences between the reactivity of CUOOH and H2O2 were revealed when the interaction of these oxidants with microsomal cytochromes P-450 or b5 was analyzed spectrophotometrically under anaerobic conditions in the presence of reduced pyridine nucleotides. The addition of hydrogen peroxide together with NADPH or NADH to an anaerobic suspension of liver microsoms indicates that NADPH is rapidly oxidized while NADH is only very slowly oxidized. The simultaneous addition of NADH and NADPH together with H2O2 results in only the rapid oxidation of NADPH. It is found that the rate of the hydrogen-peroxide-initiated oxidation of NADPH is stimulated in the presence of a substrate such as benzphetamine and inhibited in the presence of carbon monoxide." @default.
- W305851178 created "2016-06-24" @default.
- W305851178 creator A5029191285 @default.
- W305851178 creator A5034121540 @default.
- W305851178 creator A5088252762 @default.
- W305851178 date "1980-01-01" @default.
- W305851178 modified "2023-09-23" @default.
- W305851178 title "COMPARISON OF THE INTERACTION OF CUMENE HYDROPEROXIDE AND HYDROGEN PEROXIDE WITH LIVER MICROSOMAL CYTOCHROMES" @default.
- W305851178 cites W2001297244 @default.
- W305851178 cites W2033182087 @default.
- W305851178 doi "https://doi.org/10.1016/b978-0-12-187701-9.50081-4" @default.
- W305851178 hasPublicationYear "1980" @default.
- W305851178 type Work @default.
- W305851178 sameAs 305851178 @default.
- W305851178 citedByCount "4" @default.
- W305851178 crossrefType "book-chapter" @default.
- W305851178 hasAuthorship W305851178A5029191285 @default.
- W305851178 hasAuthorship W305851178A5034121540 @default.
- W305851178 hasAuthorship W305851178A5088252762 @default.
- W305851178 hasConcept C111368507 @default.
- W305851178 hasConcept C127313418 @default.
- W305851178 hasConcept C155647269 @default.
- W305851178 hasConcept C161790260 @default.
- W305851178 hasConcept C178790620 @default.
- W305851178 hasConcept C181199279 @default.
- W305851178 hasConcept C185592680 @default.
- W305851178 hasConcept C2777289219 @default.
- W305851178 hasConcept C2778113725 @default.
- W305851178 hasConcept C2778215507 @default.
- W305851178 hasConcept C2780768313 @default.
- W305851178 hasConcept C2781048764 @default.
- W305851178 hasConcept C533411734 @default.
- W305851178 hasConcept C55493867 @default.
- W305851178 hasConcept C75473681 @default.
- W305851178 hasConcept C87644729 @default.
- W305851178 hasConceptScore W305851178C111368507 @default.
- W305851178 hasConceptScore W305851178C127313418 @default.
- W305851178 hasConceptScore W305851178C155647269 @default.
- W305851178 hasConceptScore W305851178C161790260 @default.
- W305851178 hasConceptScore W305851178C178790620 @default.
- W305851178 hasConceptScore W305851178C181199279 @default.
- W305851178 hasConceptScore W305851178C185592680 @default.
- W305851178 hasConceptScore W305851178C2777289219 @default.
- W305851178 hasConceptScore W305851178C2778113725 @default.
- W305851178 hasConceptScore W305851178C2778215507 @default.
- W305851178 hasConceptScore W305851178C2780768313 @default.
- W305851178 hasConceptScore W305851178C2781048764 @default.
- W305851178 hasConceptScore W305851178C533411734 @default.
- W305851178 hasConceptScore W305851178C55493867 @default.
- W305851178 hasConceptScore W305851178C75473681 @default.
- W305851178 hasConceptScore W305851178C87644729 @default.
- W305851178 hasLocation W3058511781 @default.
- W305851178 hasOpenAccess W305851178 @default.
- W305851178 hasPrimaryLocation W3058511781 @default.
- W305851178 hasRelatedWork W1943555017 @default.
- W305851178 hasRelatedWork W1982235385 @default.
- W305851178 hasRelatedWork W2000479287 @default.
- W305851178 hasRelatedWork W2038740781 @default.
- W305851178 hasRelatedWork W2050218336 @default.
- W305851178 hasRelatedWork W2087294636 @default.
- W305851178 hasRelatedWork W2088408037 @default.
- W305851178 hasRelatedWork W2092918736 @default.
- W305851178 hasRelatedWork W2095411323 @default.
- W305851178 hasRelatedWork W2280720595 @default.
- W305851178 isParatext "false" @default.
- W305851178 isRetracted "false" @default.
- W305851178 magId "305851178" @default.
- W305851178 workType "book-chapter" @default.