Matches in SemOpenAlex for { <https://semopenalex.org/work/W3058547524> ?p ?o ?g. }
- W3058547524 abstract "ABSTRACT The role of the cannabinoid receptor 2 (CNR2) is still poorly described in sensory epithelia. We found strong cnr2 expression in hair cells (HCs) of the inner ear and the lateral line (LL), a superficial sensory structure in fish. Next, we demonstrated that sensory synapses in HCs were severely perturbed in zebrafish larvae lacking cnr2. Appearance and distribution of presynaptic ribbons and calcium channels (Ca v 1.3) were profoundly altered in mutant animals. Clustering of membrane-associated guanylate kinase (MAGUK) in post-synaptic densities (PSDs) was also heavily affected, suggesting a role for cnr2 for maintaining the structure of the sensory synapse. Furthermore, vesicular trafficking in HCs was strongly perturbed suggesting a retrograde action of the endocannabinoid system (ECs) mediated via cnr2 that was modulating HC mechanotransduction. We found similar perturbations in retinal ribbon synapses. Finally, we showed that larval swimming behaviors after sound and light stimulations were significantly different in mutant animals. Thus, we propose that cnr2 is critical for the processing of sensory information in the developing larva." @default.
- W3058547524 created "2020-08-24" @default.
- W3058547524 creator A5006204957 @default.
- W3058547524 creator A5007263489 @default.
- W3058547524 creator A5009516176 @default.
- W3058547524 creator A5038131810 @default.
- W3058547524 creator A5055821949 @default.
- W3058547524 creator A5057100407 @default.
- W3058547524 creator A5064855040 @default.
- W3058547524 creator A5069828731 @default.
- W3058547524 creator A5074760499 @default.
- W3058547524 creator A5078689022 @default.
- W3058547524 creator A5087555842 @default.
- W3058547524 creator A5091582016 @default.
- W3058547524 date "2020-08-19" @default.
- W3058547524 modified "2023-10-18" @default.
- W3058547524 title "Cnr2 is important for Ribbon Synapse Maturation and Function in Hair Cells and Photoreceptors" @default.
- W3058547524 cites W150425010 @default.
- W3058547524 cites W1506027146 @default.
- W3058547524 cites W1509834006 @default.
- W3058547524 cites W1538619419 @default.
- W3058547524 cites W1670633125 @default.
- W3058547524 cites W1703858137 @default.
- W3058547524 cites W1827216551 @default.
- W3058547524 cites W1900006972 @default.
- W3058547524 cites W1916040231 @default.
- W3058547524 cites W1949541784 @default.
- W3058547524 cites W1963617492 @default.
- W3058547524 cites W1967805295 @default.
- W3058547524 cites W1968650627 @default.
- W3058547524 cites W1968669554 @default.
- W3058547524 cites W1969652103 @default.
- W3058547524 cites W1969944184 @default.
- W3058547524 cites W1973841770 @default.
- W3058547524 cites W1977668474 @default.
- W3058547524 cites W1981075126 @default.
- W3058547524 cites W1981091892 @default.
- W3058547524 cites W1984056122 @default.
- W3058547524 cites W1984830616 @default.
- W3058547524 cites W1986434175 @default.
- W3058547524 cites W1988341123 @default.
- W3058547524 cites W1989249810 @default.
- W3058547524 cites W1989353122 @default.
- W3058547524 cites W1989756472 @default.
- W3058547524 cites W1990573399 @default.
- W3058547524 cites W1991302410 @default.
- W3058547524 cites W1993493807 @default.
- W3058547524 cites W1995912317 @default.
- W3058547524 cites W1996993481 @default.
- W3058547524 cites W1998473889 @default.
- W3058547524 cites W1999024564 @default.
- W3058547524 cites W2000076301 @default.
- W3058547524 cites W2002535987 @default.
- W3058547524 cites W2003325554 @default.
- W3058547524 cites W2004684000 @default.
- W3058547524 cites W2006321295 @default.
- W3058547524 cites W2006623752 @default.
- W3058547524 cites W2007337163 @default.
- W3058547524 cites W2007531137 @default.
- W3058547524 cites W2009066226 @default.
- W3058547524 cites W2009587806 @default.
- W3058547524 cites W2009956304 @default.
- W3058547524 cites W2012237852 @default.
- W3058547524 cites W2012836418 @default.
- W3058547524 cites W2013846991 @default.
- W3058547524 cites W2020008923 @default.
- W3058547524 cites W2020785240 @default.
- W3058547524 cites W2023989277 @default.
- W3058547524 cites W2026628411 @default.
- W3058547524 cites W2027361335 @default.
- W3058547524 cites W2027642569 @default.
- W3058547524 cites W2032368486 @default.
- W3058547524 cites W2033328335 @default.
- W3058547524 cites W2033347933 @default.
- W3058547524 cites W2034742060 @default.
- W3058547524 cites W2035943007 @default.
- W3058547524 cites W2038125912 @default.
- W3058547524 cites W2040032122 @default.
- W3058547524 cites W2041147278 @default.
- W3058547524 cites W2041799178 @default.
- W3058547524 cites W2043559472 @default.
- W3058547524 cites W2050022483 @default.
- W3058547524 cites W2051780627 @default.
- W3058547524 cites W2056365858 @default.
- W3058547524 cites W2056415769 @default.
- W3058547524 cites W2056829537 @default.
- W3058547524 cites W2057725339 @default.
- W3058547524 cites W2057934269 @default.
- W3058547524 cites W2058562909 @default.
- W3058547524 cites W2061018405 @default.
- W3058547524 cites W2062417095 @default.
- W3058547524 cites W2062605235 @default.
- W3058547524 cites W2065817255 @default.
- W3058547524 cites W2070074690 @default.
- W3058547524 cites W2071469863 @default.
- W3058547524 cites W2079971040 @default.
- W3058547524 cites W2080649553 @default.
- W3058547524 cites W2082834127 @default.
- W3058547524 cites W2084864774 @default.
- W3058547524 cites W2086185798 @default.