FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3059453642> ?p ?o ?g. }

• W3059453642 endingPage "161" @default.
• W3059453642 startingPage "147" @default.
• W3059453642 abstract "Liver cancer (hepatocellular carcinoma, HCC) is one of the most prevalent cancers worldwide. Several etiological factors of HCC, including hepatitis B or hepatitis C virus infection, liver cirrhosis and aflatoxin B1 intake has been identified. HBx, which is an oncogenic protein encoded by the hepatitis B virus, is strongly associated with hepatocarcinogenesis. Using stable HBx-expressing cell, we showed that HBx induced chromosome gain, with amplification of centrosomes numbers and deregulation of centrosome ultrastructure. To dissect the mechanism for chromosome instability, our result revealed that HBx contributed to a hyperactive centrosome-microtubule dynamics by accelerating microtubule nucleation and polymerization. Further investigations suggested that HBx interacted with a centrosome linker protein TAX1BP2, which has previously been shown to function as an intrinsic block of centrosome amplification and a tumour suppressor in HCC. Restoring TAX1BP2 was able to block HBx-mediated centrosome amplification and abolish the HBx-mediated centrosome aberration, thereby suppressing chromosome instability. Thus, we demonstrate here a mechanism by which HBx deregulates centrosome-microtubule dynamics through interacting with TAX1BP2, which underlines the possibility of restoration of TAX1BP2 to rescue cells from chromosome instability." @default.
• W3059453642 created "2020-08-24" @default.
• W3059453642 creator A5000754014 @default.
• W3059453642 creator A5012104344 @default.
• W3059453642 creator A5023737646 @default.
• W3059453642 creator A5046155823 @default.
• W3059453642 creator A5062743704 @default.
• W3059453642 creator A5070084989 @default.
• W3059453642 creator A5076605084 @default.
• W3059453642 creator A5076910312 @default.
• W3059453642 date "2020-11-01" @default.
• W3059453642 modified "2023-10-18" @default.
• W3059453642 title "Centrosomal protein TAX1BP2 inhibits centrosome-microtubules aberrations induced by hepatitis B virus X oncoprotein" @default.
• W3059453642 cites W1558701786 @default.
• W3059453642 cites W1690185597 @default.
• W3059453642 cites W1757407923 @default.
• W3059453642 cites W1965560988 @default.
• W3059453642 cites W1978438231 @default.
• W3059453642 cites W1985864215 @default.
• W3059453642 cites W1989312510 @default.
• W3059453642 cites W1991033145 @default.
• W3059453642 cites W2007098353 @default.
• W3059453642 cites W2024104219 @default.
• W3059453642 cites W2028765738 @default.
• W3059453642 cites W2057811851 @default.
• W3059453642 cites W2065581527 @default.
• W3059453642 cites W2067290862 @default.
• W3059453642 cites W2068121956 @default.
• W3059453642 cites W2090296214 @default.
• W3059453642 cites W2104868487 @default.
• W3059453642 cites W2111957657 @default.
• W3059453642 cites W2151884280 @default.
• W3059453642 cites W2154855968 @default.
• W3059453642 cites W2157319245 @default.
• W3059453642 cites W2161155561 @default.
• W3059453642 cites W2162311131 @default.
• W3059453642 cites W2164680318 @default.
• W3059453642 cites W2193175619 @default.
• W3059453642 cites W2472424268 @default.
• W3059453642 cites W2556091772 @default.
• W3059453642 cites W2789291164 @default.
• W3059453642 cites W2802035309 @default.
• W3059453642 cites W3021431521 @default.
• W3059453642 doi "https://doi.org/10.1016/j.canlet.2020.08.005" @default.
• W3059453642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32827601" @default.
• W3059453642 hasPublicationYear "2020" @default.
• W3059453642 type Work @default.
• W3059453642 sameAs 3059453642 @default.
• W3059453642 citedByCount "3" @default.
• W3059453642 countsByYear W30594536422021 @default.
• W3059453642 countsByYear W30594536422022 @default.
• W3059453642 countsByYear W30594536422023 @default.
• W3059453642 crossrefType "journal-article" @default.
• W3059453642 hasAuthorship W3059453642A5000754014 @default.
• W3059453642 hasAuthorship W3059453642A5012104344 @default.
• W3059453642 hasAuthorship W3059453642A5023737646 @default.
• W3059453642 hasAuthorship W3059453642A5046155823 @default.
• W3059453642 hasAuthorship W3059453642A5062743704 @default.
• W3059453642 hasAuthorship W3059453642A5070084989 @default.
• W3059453642 hasAuthorship W3059453642A5076605084 @default.
• W3059453642 hasAuthorship W3059453642A5076910312 @default.
• W3059453642 hasConcept C10447061 @default.
• W3059453642 hasConcept C1491633281 @default.
• W3059453642 hasConcept C159047783 @default.
• W3059453642 hasConcept C185592680 @default.
• W3059453642 hasConcept C20418707 @default.
• W3059453642 hasConcept C2522874641 @default.
• W3059453642 hasConcept C2780593183 @default.
• W3059453642 hasConcept C29537977 @default.
• W3059453642 hasConcept C55493867 @default.
• W3059453642 hasConcept C67567795 @default.
• W3059453642 hasConcept C86803240 @default.
• W3059453642 hasConcept C95444343 @default.
• W3059453642 hasConceptScore W3059453642C10447061 @default.
• W3059453642 hasConceptScore W3059453642C1491633281 @default.
• W3059453642 hasConceptScore W3059453642C159047783 @default.
• W3059453642 hasConceptScore W3059453642C185592680 @default.
• W3059453642 hasConceptScore W3059453642C20418707 @default.
• W3059453642 hasConceptScore W3059453642C2522874641 @default.
• W3059453642 hasConceptScore W3059453642C2780593183 @default.
• W3059453642 hasConceptScore W3059453642C29537977 @default.
• W3059453642 hasConceptScore W3059453642C55493867 @default.
• W3059453642 hasConceptScore W3059453642C67567795 @default.
• W3059453642 hasConceptScore W3059453642C86803240 @default.
• W3059453642 hasConceptScore W3059453642C95444343 @default.
• W3059453642 hasFunder F4320306709 @default.
• W3059453642 hasFunder F4320321199 @default.
• W3059453642 hasLocation W30594536421 @default.
• W3059453642 hasOpenAccess W3059453642 @default.
• W3059453642 hasPrimaryLocation W30594536421 @default.
• W3059453642 hasRelatedWork W1487857142 @default.
• W3059453642 hasRelatedWork W1534984749 @default.
• W3059453642 hasRelatedWork W2015490746 @default.
• W3059453642 hasRelatedWork W2040667056 @default.
• W3059453642 hasRelatedWork W2092808149 @default.
• W3059453642 hasRelatedWork W2100813299 @default.
• W3059453642 hasRelatedWork W2414947116 @default.
• W3059453642 hasRelatedWork W2769819317 @default.

• next