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• W3060453609 endingPage "129117" @default.
• W3060453609 startingPage "129117" @default.
• W3060453609 abstract "• Benzimidazole based novel ligands and their silver and copper complexes are prepared. • Transmetalation of silver complex into copper complex. • The solvent polarity were studied by FT-IR, FT-Raman, NMR and fragmentation pattern in ESI-MS and HRMS. • In vitro surveys on antimicrobial impending of the compounds. • The most potent silver and copper complex shows high degree of activity against Candida albicans . • Proficient antimicrobial effect of compounds by membrane obliteration mechanism. Benzimidazolium-based novel compounds containing ethyl group as a substituent were prepared and their silver and copper complexes were synthesized to evaluate the antifungal properties. In the present study, we have designed trisbenzimidazolydine benzene and silver and copper complexes. The trisbenzimidazolium salt L2 reacts with 1.5 equiv of Ag 2 O to yield the trinuclear Ag I hexacarbene complex Ag(I)-NHC, which is transmetalation of Ag-NHC with 3 equiv of CuI yields the trinuclear Cu I hexacarbene complex Cu(I)-NHC, respectively, where there their formation is influenced by the polarity of solvent as evidenced by FT-IR, FT-Raman, NMR and Mass Spectrometry (Electrospray Ionization/High Resolution) data distinguished by examining the antimicrobial activity, MIC determination and SEM analysis against antimicrobial growth. The inhibitory effects of tested compounds were investigated against Candida albicans and several other medicinally important pathogens. The most potent Ag(I)-NHC and Cu(I)-NHC complexes showing a higher degree of activity against C. albicans among the other tested strains. A significant level of growth in C. albicans was clearly observed through Minimum Inhibitory Concentration (MIC), here the least inhibitory concentration of Ag(I)-NHC (0.165 mg/mL) was several times lesser than L1, L2 and Cu(I)-NHC but higher than the positive control Amphotericin B (0.065 mg/mL). The impacts of ligands and metal complexes on cell wall integrity of C. albicans were investigated by scanning electron microscope (SEM) showed wrinkled and distinguished morphological features by higher accumulation of Propidium Iodide (PI). Further, the mode of action was found the cell death medicated due to severe loss of membrane integrity." @default.
• W3060453609 created "2020-08-24" @default.
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• W3060453609 date "2021-02-01" @default.
• W3060453609 modified "2023-09-23" @default.
• W3060453609 title "Killing effects of Candida albicans through alteration of cellular morphology and growth metabolism using Tris-NHC ligand coordinated to AgI and CuI" @default.
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• W3060453609 doi "https://doi.org/10.1016/j.molstruc.2020.129117" @default.
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