FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3060984057> ?p ?o ?g. }

• W3060984057 endingPage "2688" @default.
• W3060984057 startingPage "2681" @default.
• W3060984057 abstract "Medication overuse headache is estimated to affect 2% of the population, and is ranked in the top 20 most disabling disorders due to its high level of disability. Several therapies used in the treatment of acute migraine are thought to be associated with medication overuse headache, including opioids and triptans. With limited treatment options, it is critical to determine the risk profile of novel therapies prior to their widespread use. The current study explores the potential medication overuse risk of two novel therapeutic drug classes, namely the ditans: 5-HT1F receptor agonists, and the gepants: calcitonin gene-related peptide receptor antagonists, in a preclinical model of medication overuse. Persistent exposure of mice to the 5-HT1F agonist LY344864, but not olcegepant produced a significant reduction in hind paw and orofacial mechanical withdrawal thresholds as a surrogate readout of allodynia. In agreement, only LY344864 induced neuroplastic changes in trigeminal sensory afferents, increasing calcitonin gene-related peptide expression and basal trigeminal nociception. Our data highlight a differential medication overuse headache risk profile for the ditan and gepant classes of drugs that has important implications for their clinical use and patient education to help reduce the burden of medication overuse headache." @default.
• W3060984057 created "2020-08-24" @default.
• W3060984057 creator A5007287217 @default.
• W3060984057 creator A5014056970 @default.
• W3060984057 creator A5034903058 @default.
• W3060984057 creator A5055177253 @default.
• W3060984057 creator A5058994427 @default.
• W3060984057 creator A5065566445 @default.
• W3060984057 creator A5085638268 @default.
• W3060984057 date "2020-08-18" @default.
• W3060984057 modified "2023-10-14" @default.
• W3060984057 title "Differential medication overuse risk of novel anti-migraine therapeutics" @default.
• W3060984057 cites W1793427412 @default.
• W3060984057 cites W1966430730 @default.
• W3060984057 cites W2027079223 @default.
• W3060984057 cites W2076898460 @default.
• W3060984057 cites W2098082628 @default.
• W3060984057 cites W2111548432 @default.
• W3060984057 cites W2124796000 @default.
• W3060984057 cites W2172201406 @default.
• W3060984057 cites W2751761148 @default.
• W3060984057 cites W2766679464 @default.
• W3060984057 cites W2801085490 @default.
• W3060984057 cites W2895868360 @default.
• W3060984057 cites W2903680925 @default.
• W3060984057 cites W2912654919 @default.
• W3060984057 cites W2915485123 @default.
• W3060984057 cites W2935951435 @default.
• W3060984057 cites W2970892087 @default.
• W3060984057 cites W2971348120 @default.
• W3060984057 cites W2973889334 @default.
• W3060984057 cites W2986041218 @default.
• W3060984057 cites W3001392145 @default.
• W3060984057 doi "https://doi.org/10.1093/brain/awaa211" @default.
• W3060984057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7523700" @default.
• W3060984057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32810212" @default.
• W3060984057 hasPublicationYear "2020" @default.
• W3060984057 type Work @default.
• W3060984057 sameAs 3060984057 @default.
• W3060984057 citedByCount "31" @default.
• W3060984057 countsByYear W30609840572020 @default.
• W3060984057 countsByYear W30609840572021 @default.
• W3060984057 countsByYear W30609840572022 @default.
• W3060984057 countsByYear W30609840572023 @default.
• W3060984057 crossrefType "journal-article" @default.
• W3060984057 hasAuthorship W3060984057A5007287217 @default.
• W3060984057 hasAuthorship W3060984057A5014056970 @default.
• W3060984057 hasAuthorship W3060984057A5034903058 @default.
• W3060984057 hasAuthorship W3060984057A5055177253 @default.
• W3060984057 hasAuthorship W3060984057A5058994427 @default.
• W3060984057 hasAuthorship W3060984057A5065566445 @default.
• W3060984057 hasAuthorship W3060984057A5085638268 @default.
• W3060984057 hasBestOaLocation W30609840571 @default.
• W3060984057 hasConcept C118303440 @default.
• W3060984057 hasConcept C126322002 @default.
• W3060984057 hasConcept C163170386 @default.
• W3060984057 hasConcept C170493617 @default.
• W3060984057 hasConcept C177713679 @default.
• W3060984057 hasConcept C2777119127 @default.
• W3060984057 hasConcept C2778541695 @default.
• W3060984057 hasConcept C2778871607 @default.
• W3060984057 hasConcept C2778938600 @default.
• W3060984057 hasConcept C2908647359 @default.
• W3060984057 hasConcept C42219234 @default.
• W3060984057 hasConcept C60644358 @default.
• W3060984057 hasConcept C71924100 @default.
• W3060984057 hasConcept C86803240 @default.
• W3060984057 hasConcept C98274493 @default.
• W3060984057 hasConcept C99454951 @default.
• W3060984057 hasConceptScore W3060984057C118303440 @default.
• W3060984057 hasConceptScore W3060984057C126322002 @default.
• W3060984057 hasConceptScore W3060984057C163170386 @default.
• W3060984057 hasConceptScore W3060984057C170493617 @default.
• W3060984057 hasConceptScore W3060984057C177713679 @default.
• W3060984057 hasConceptScore W3060984057C2777119127 @default.
• W3060984057 hasConceptScore W3060984057C2778541695 @default.
• W3060984057 hasConceptScore W3060984057C2778871607 @default.
• W3060984057 hasConceptScore W3060984057C2778938600 @default.
• W3060984057 hasConceptScore W3060984057C2908647359 @default.
• W3060984057 hasConceptScore W3060984057C42219234 @default.
• W3060984057 hasConceptScore W3060984057C60644358 @default.
• W3060984057 hasConceptScore W3060984057C71924100 @default.
• W3060984057 hasConceptScore W3060984057C86803240 @default.
• W3060984057 hasConceptScore W3060984057C98274493 @default.
• W3060984057 hasConceptScore W3060984057C99454951 @default.
• W3060984057 hasFunder F4320307874 @default.
• W3060984057 hasFunder F4320332161 @default.
• W3060984057 hasFunder F4320334626 @default.
• W3060984057 hasIssue "9" @default.
• W3060984057 hasLocation W30609840571 @default.
• W3060984057 hasLocation W30609840572 @default.
• W3060984057 hasLocation W30609840573 @default.
• W3060984057 hasLocation W30609840574 @default.
• W3060984057 hasLocation W30609840575 @default.
• W3060984057 hasLocation W30609840576 @default.
• W3060984057 hasOpenAccess W3060984057 @default.
• W3060984057 hasPrimaryLocation W30609840571 @default.
• W3060984057 hasRelatedWork W2068817149 @default.

• next