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• W3061798809 endingPage "123" @default.
• W3061798809 startingPage "109" @default.
• W3061798809 abstract "The discovery of the rapid antidepressant effects of the dissociative anaesthetic ketamine, an uncompetitive N-Methyl-D-Aspartate receptor antagonist, is arguably the most important breakthrough in depression research in the last 50 years. Ketamine remains an off-label treatment for treatment-resistant depression with factors that limit widespread use including its dissociative effects and abuse potential. Ketamine is a racemic mixture, composed of equal amounts of (S)-ketamine and (R)-ketamine. An (S)-ketamine nasal spray has been developed and approved for use in treatment-resistant depression in the United States and Europe; however, some concerns regarding efficacy and side effects remain. Although (R)-ketamine is a less potent N-Methyl-D-Aspartate receptor antagonist than (S)-ketamine, increasing preclinical evidence suggests (R)-ketamine may have more potent and longer lasting antidepressant effects than (S)-ketamine, alongside fewer side effects. Furthermore, a recent pilot trial of (R)-ketamine has demonstrated rapid-acting and sustained antidepressant effects in individuals with treatment-resistant depression. Research is ongoing to determine the specific cellular and molecular mechanisms underlying the antidepressant actions of ketamine and its component enantiomers in an effort to develop future rapid-acting antidepressants that lack undesirable effects. Here, we briefly review findings regarding the antidepressant effects of ketamine and its enantiomers before considering underlying mechanisms including N-Methyl-D-Aspartate receptor antagonism, γ-aminobutyric acid-ergic interneuron inhibition, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor activation, brain-derived neurotrophic factor and tropomyosin kinase B signalling, mammalian target of rapamycin complex 1 and extracellular signal-regulated kinase signalling, inhibition of glycogen synthase kinase-3 and inhibition of lateral habenula bursting, alongside potential roles of the monoaminergic and opioid receptor systems." @default.
• W3061798809 created "2020-08-24" @default.
• W3061798809 creator A5021214721 @default.
• W3061798809 creator A5053590250 @default.
• W3061798809 creator A5055176833 @default.
• W3061798809 date "2020-11-06" @default.
• W3061798809 modified "2023-10-18" @default.
• W3061798809 title "Ketamine: A tale of two enantiomers" @default.
• W3061798809 cites W1533152672 @default.
• W3061798809 cites W1542925768 @default.
• W3061798809 cites W1586476523 @default.
• W3061798809 cites W1667725090 @default.
• W3061798809 cites W1746596066 @default.
• W3061798809 cites W1948877773 @default.
• W3061798809 cites W1969644317 @default.
• W3061798809 cites W1970448316 @default.
• W3061798809 cites W1976392245 @default.
• W3061798809 cites W1981097208 @default.
• W3061798809 cites W1982874357 @default.
• W3061798809 cites W1991333985 @default.
• W3061798809 cites W1995331365 @default.
• W3061798809 cites W1996357107 @default.
• W3061798809 cites W1998203489 @default.
• W3061798809 cites W2002338226 @default.
• W3061798809 cites W2006460397 @default.
• W3061798809 cites W2007644527 @default.
• W3061798809 cites W2009175060 @default.
• W3061798809 cites W2009208338 @default.
• W3061798809 cites W2011633672 @default.
• W3061798809 cites W2011804248 @default.
• W3061798809 cites W2014192652 @default.
• W3061798809 cites W2014381681 @default.
• W3061798809 cites W2016292245 @default.
• W3061798809 cites W2016552134 @default.
• W3061798809 cites W2017803035 @default.
• W3061798809 cites W2023081218 @default.
• W3061798809 cites W2023422390 @default.
• W3061798809 cites W2024636695 @default.
• W3061798809 cites W2027304084 @default.
• W3061798809 cites W2031031941 @default.
• W3061798809 cites W2032558533 @default.
• W3061798809 cites W2032739515 @default.
• W3061798809 cites W2035312998 @default.
• W3061798809 cites W2035651792 @default.
• W3061798809 cites W2037018768 @default.
• W3061798809 cites W2045075041 @default.
• W3061798809 cites W2045893995 @default.
• W3061798809 cites W2047804695 @default.
• W3061798809 cites W2051187163 @default.
• W3061798809 cites W2052009158 @default.
• W3061798809 cites W2052665050 @default.
• W3061798809 cites W2054153218 @default.
• W3061798809 cites W2055376154 @default.
• W3061798809 cites W2056406527 @default.
• W3061798809 cites W2057845292 @default.
• W3061798809 cites W2059957672 @default.
• W3061798809 cites W2061711185 @default.
• W3061798809 cites W2064468814 @default.
• W3061798809 cites W2070796188 @default.
• W3061798809 cites W2071801806 @default.
• W3061798809 cites W2072457730 @default.
• W3061798809 cites W2080654671 @default.
• W3061798809 cites W2083549526 @default.
• W3061798809 cites W2089198034 @default.
• W3061798809 cites W2089351762 @default.
• W3061798809 cites W2090648684 @default.
• W3061798809 cites W2091194550 @default.
• W3061798809 cites W2099078941 @default.
• W3061798809 cites W2100347745 @default.
• W3061798809 cites W2106438910 @default.
• W3061798809 cites W2106636235 @default.
• W3061798809 cites W2109309568 @default.
• W3061798809 cites W2109334244 @default.
• W3061798809 cites W2118815581 @default.
• W3061798809 cites W2119162169 @default.
• W3061798809 cites W2129143684 @default.
• W3061798809 cites W2129721670 @default.
• W3061798809 cites W2145731152 @default.
• W3061798809 cites W2146170141 @default.
• W3061798809 cites W2147868051 @default.
• W3061798809 cites W2150227040 @default.
• W3061798809 cites W2151443708 @default.
• W3061798809 cites W2157040702 @default.
• W3061798809 cites W2157504436 @default.
• W3061798809 cites W2166320770 @default.
• W3061798809 cites W2171245354 @default.
• W3061798809 cites W2178527379 @default.
• W3061798809 cites W2326374493 @default.
• W3061798809 cites W2330587564 @default.
• W3061798809 cites W2337679024 @default.
• W3061798809 cites W2346390990 @default.
• W3061798809 cites W2375106168 @default.
• W3061798809 cites W2400771625 @default.
• W3061798809 cites W2401002261 @default.
• W3061798809 cites W2484912492 @default.
• W3061798809 cites W2526511830 @default.
• W3061798809 cites W2566965256 @default.
• W3061798809 cites W2581419519 @default.

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