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- W30619332 abstract "INTRODUCTION In this paper I will summarize our understanding of the molecular basis of the following phenomena involving the function and synthesis of the bacteriophage λ repressor. In its classical role, repressor turns off transcription of other phage genes at the promoters P L and P R , thereby maintaining the phage chromosome as prophage in a lysogenic bacterium. These phage genes are thus heterogenously regulated by repressor (Fig. 1). In lysogens the repressor gene ( CI ) is autogenously regulated. Repressor activates CI transcription at low concentrations and represses it at high concentrations. The promoter for CI transcription in lysogens is called P RM ( p romoter for r epressor m aintenance) (Fig. 1). Upon infection of nonlysogens (i.e., in the absence of repressor), repressor is synthesized in a mode different from that in lysogens. In this case, CI is transcribed under the direction of regulatory proteins encoded by phage genes CII and CIII . The promoter used is called P RE ( p romoter for r epressor e stablishment) (Fig. 1). In a cell destined to become a lysogen, this burst of repressor turns off transcription of CII and CIII and of other phage genes as it turns on transcription of CI from P RM . Phage λ sometimes grows lytically in nonlysogens. In this case, synthesis of a second repressor encoded by the cro (or tof ) gene is required. The cro product represses early genes, including cro , by blocking transcription beginning at P L and P R . In addition, the cro protein represses transcription of CI originating at P RM . Treatment of lysogens..." @default.
- W30619332 created "2016-06-24" @default.
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- W30619332 date "1980-01-01" @default.
- W30619332 modified "2023-09-23" @default.
- W30619332 title "λ Repressor Function and Structure" @default.
- W30619332 doi "https://doi.org/10.1101/087969133.7.325" @default.
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