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- W3062198497 abstract "Abstract Changes in macrophage phenotype in injured muscle profoundly influence regeneration. In particular, the shift of macrophages from a proinflammatory (M1 biased) phenotype to a proregenerative (M2 biased) phenotype characterized by expression of CD206 and CD163 is essential for normal repair. According to the current canonical mechanism regulating for M1/M2 phenotype transition, signaling through PPARδ is necessary for obtaining the M2-biased phenotype. Our findings confirm that the murine myeloid cell–targeted deletion of Ppard reduces expression in vitro of genes that are activated in M2-biased macrophages; however, the mutation in mice in vivo increased numbers of CD206+ M2-biased macrophages and did not reduce the expression of phenotypic markers of M2-biased macrophages in regenerating muscle. Nevertheless, the mutation impaired CCL2-mediated chemotaxis of macrophages and slowed revascularization of injured muscle. In contrast, null mutation of IL-10 diminished M2-biased macrophages but produced no defects in muscle revascularization. Our results provide two significant findings. First, they illustrate that mechanisms that regulate macrophage phenotype transitions in vitro are not always predictive of mechanisms that are most important in vivo. Second, they show that mechanisms that regulate macrophage phenotype transitions differ in different in vivo environments." @default.
- W3062198497 created "2020-08-24" @default.
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- W3062198497 date "2020-09-15" @default.
- W3062198497 modified "2023-09-30" @default.
- W3062198497 title "Differential Effects of Myeloid Cell PPARδ and IL-10 in Regulating Macrophage Recruitment, Phenotype, and Regeneration following Acute Muscle Injury" @default.
- W3062198497 cites W1494611500 @default.
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- W3062198497 cites W1604044665 @default.
- W3062198497 cites W1975031413 @default.
- W3062198497 cites W1976621212 @default.
- W3062198497 cites W1979173328 @default.
- W3062198497 cites W1980218034 @default.
- W3062198497 cites W1999353686 @default.
- W3062198497 cites W2008183439 @default.
- W3062198497 cites W2017429680 @default.
- W3062198497 cites W2017671227 @default.
- W3062198497 cites W2018448066 @default.
- W3062198497 cites W2022447085 @default.
- W3062198497 cites W2037716289 @default.
- W3062198497 cites W2046935888 @default.
- W3062198497 cites W2050441306 @default.
- W3062198497 cites W2059906195 @default.
- W3062198497 cites W2062520524 @default.
- W3062198497 cites W2066704041 @default.
- W3062198497 cites W2078274599 @default.
- W3062198497 cites W2088148916 @default.
- W3062198497 cites W2089432984 @default.
- W3062198497 cites W2098940221 @default.
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- W3062198497 cites W2110120495 @default.
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- W3062198497 cites W2140980131 @default.
- W3062198497 cites W2141044457 @default.
- W3062198497 cites W2143082806 @default.
- W3062198497 cites W2143275279 @default.
- W3062198497 cites W2144067550 @default.
- W3062198497 cites W2145697808 @default.
- W3062198497 cites W2150697205 @default.
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- W3062198497 cites W2587398364 @default.
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- W3062198497 cites W2761764474 @default.
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- W3062198497 cites W2883428285 @default.
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- W3062198497 doi "https://doi.org/10.4049/jimmunol.2000247" @default.
- W3062198497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7484367" @default.
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- W3062198497 hasPublicationYear "2020" @default.
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