FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3062521503> ?p ?o ?g. }

• W3062521503 endingPage "2698" @default.
• W3062521503 startingPage "2687" @default.
• W3062521503 abstract "Astaxanthin is a red lipophilic carotenoid that is often undetectable in human plasma due to the limited supply in typical Western diets. Despite its presence at lower than detectable concentrations, previous clinical feeding studies have reported that astaxanthin exhibits potent antioxidant properties.We examined astaxanthin accumulation and its effects on gut microbiota, inflammation, and whole-body metabolic homeostasis in wild-type C57BL/6 J (WT) and β-carotene oxygenase 2 (BCO2) knockout (KO) mice.Six-wk-old male and female BCO2 KO and WT mice were provided with either nonpurified AIN93M (e.g., control diet) or the control diet supplemented with 0.04% astaxanthin (wt/wt) ad libitum for 8 wk. Whole-body energy expenditure was measured by indirect calorimetry. Feces were collected from individual mice for short-chain fatty acid assessment. Hepatic astaxanthin concentrations and liver metabolic markers, cecal gut microbiota profiling, inflammation markers in colonic lamina propria, and plasma samples were assessed. Data were analyzed by 3-way ANOVA followed by Tukey's post hoc analysis.BCO2 KO but not WT mice fed astaxanthin had ∼10-fold more of this compound in liver than controls (P < 0.05). In terms of the microbiota composition, deletion of BCO2 was associated with a significantly increased abundance of Mucispirillum schaedleri in mice regardless of gender. In addition to more liver astaxanthin in male KO compared with WT mice fed astaxanthin, the abundance of gut Akkermansia muciniphila was 385% greater, plasma glucagon-like peptide 1 was 27% greater, plasma glucagon and IL-1β were 53% and 30% lower, respectively, and colon NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome activation was 23% lower (all P < 0.05) in male KO mice than the WT mice.Astaxanthin affects the gut microbiota composition in both genders, but the association with reductions in local and systemic inflammation, oxidative stress, and improvement of metabolic homeostasis only occurs in male mice." @default.
• W3062521503 created "2020-08-24" @default.
• W3062521503 creator A5007028168 @default.
• W3062521503 creator A5013945791 @default.
• W3062521503 creator A5014744054 @default.
• W3062521503 creator A5024260922 @default.
• W3062521503 creator A5025699862 @default.
• W3062521503 creator A5034755663 @default.
• W3062521503 creator A5035600764 @default.
• W3062521503 creator A5039139074 @default.
• W3062521503 creator A5041561990 @default.
• W3062521503 creator A5044242760 @default.
• W3062521503 creator A5062926912 @default.
• W3062521503 creator A5067080264 @default.
• W3062521503 creator A5068451283 @default.
• W3062521503 creator A5072102916 @default.
• W3062521503 creator A5084540202 @default.
• W3062521503 creator A5086722574 @default.
• W3062521503 creator A5089007558 @default.
• W3062521503 date "2020-08-18" @default.
• W3062521503 modified "2023-10-15" @default.
• W3062521503 title "Astaxanthin-Shifted Gut Microbiota Is Associated with Inflammation and Metabolic Homeostasis in Mice" @default.
• W3062521503 cites W1873700786 @default.
• W3062521503 cites W1972520384 @default.
• W3062521503 cites W1984876931 @default.
• W3062521503 cites W1995393174 @default.
• W3062521503 cites W2025660168 @default.
• W3062521503 cites W2026528407 @default.
• W3062521503 cites W2040218897 @default.
• W3062521503 cites W2042895815 @default.
• W3062521503 cites W2066483255 @default.
• W3062521503 cites W2072185305 @default.
• W3062521503 cites W2073509861 @default.
• W3062521503 cites W2089914568 @default.
• W3062521503 cites W2092636837 @default.
• W3062521503 cites W2096736123 @default.
• W3062521503 cites W2101994946 @default.
• W3062521503 cites W2119270583 @default.
• W3062521503 cites W2139205910 @default.
• W3062521503 cites W2144275312 @default.
• W3062521503 cites W2145295009 @default.
• W3062521503 cites W2151798187 @default.
• W3062521503 cites W2156370374 @default.
• W3062521503 cites W2176296158 @default.
• W3062521503 cites W2236332835 @default.
• W3062521503 cites W2273697418 @default.
• W3062521503 cites W2276108661 @default.
• W3062521503 cites W2337852911 @default.
• W3062521503 cites W2341975238 @default.
• W3062521503 cites W2345426343 @default.
• W3062521503 cites W2462368291 @default.
• W3062521503 cites W2464980650 @default.
• W3062521503 cites W2472945161 @default.
• W3062521503 cites W2507524244 @default.
• W3062521503 cites W2559109058 @default.
• W3062521503 cites W2561734318 @default.
• W3062521503 cites W2584866430 @default.
• W3062521503 cites W2588720641 @default.
• W3062521503 cites W2601263590 @default.
• W3062521503 cites W2602301706 @default.
• W3062521503 cites W2618001106 @default.
• W3062521503 cites W2735376054 @default.
• W3062521503 cites W2758322760 @default.
• W3062521503 cites W2766508658 @default.
• W3062521503 cites W2769034578 @default.
• W3062521503 cites W2779771573 @default.
• W3062521503 cites W2794419196 @default.
• W3062521503 cites W2796729208 @default.
• W3062521503 cites W2810492961 @default.
• W3062521503 cites W2832613214 @default.
• W3062521503 cites W2884481996 @default.
• W3062521503 cites W2890870104 @default.
• W3062521503 cites W2891084878 @default.
• W3062521503 cites W2891872028 @default.
• W3062521503 cites W2892229332 @default.
• W3062521503 cites W2897596394 @default.
• W3062521503 cites W2903457222 @default.
• W3062521503 cites W2910341135 @default.
• W3062521503 cites W2945757695 @default.
• W3062521503 cites W2948810272 @default.
• W3062521503 cites W2949019404 @default.
• W3062521503 cites W2969822493 @default.
• W3062521503 doi "https://doi.org/10.1093/jn/nxaa222" @default.
• W3062521503 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8023541" @default.
• W3062521503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32810865" @default.
• W3062521503 hasPublicationYear "2020" @default.
• W3062521503 type Work @default.
• W3062521503 sameAs 3062521503 @default.
• W3062521503 citedByCount "32" @default.
• W3062521503 countsByYear W30625215032020 @default.
• W3062521503 countsByYear W30625215032021 @default.
• W3062521503 countsByYear W30625215032022 @default.
• W3062521503 countsByYear W30625215032023 @default.
• W3062521503 crossrefType "journal-article" @default.
• W3062521503 hasAuthorship W3062521503A5007028168 @default.
• W3062521503 hasAuthorship W3062521503A5013945791 @default.
• W3062521503 hasAuthorship W3062521503A5014744054 @default.
• W3062521503 hasAuthorship W3062521503A5024260922 @default.

• next