FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3064523218> ?p ?o ?g. }

• W3064523218 endingPage "3912" @default.
• W3064523218 startingPage "3900" @default.
• W3064523218 abstract "Abstract Donor selection contributes to improve clinical outcomes of T-cell–replete haploidentical stem cell transplantation (haplo-SCT) with posttransplant cyclophosphamide (PT-Cy). The impact of donor age and other non-HLA donor characteristics remains a matter of debate. We performed a multicenter retrospective analysis on 990 haplo-SCTs with PT-Cy. By multivariable analysis, after adjusting for donor/recipient kinship, increasing donor age and peripheral blood stem cell graft were associated with a higher risk of grade 2 to 4 acute graft-versus-host-disease (aGVHD), whereas 2-year cumulative incidence of moderate-to-severe chronic GVHD was higher for transplants from female donors into male recipients and after myeloablative conditioning. Increasing donor age was associated with a trend for higher nonrelapse mortality (NRM) (hazard ratio [HR], 1.05; P = .057) but with a significant reduced risk of disease relapse (HR, 0.92; P = .001) and improved progression-free survival (PFS) (HR, 0.97; P = .036). Increasing recipient age was a predictor of worse overall survival (OS). Risk of relapse was higher (HR, 1.39; P &lt; .001) in patients aged ≤40 years receiving a transplant from a parent as compared with a sibling. Moreover, OS and PFS were lower when the donor was the mother rather than the father. Pretransplant active disease status was an invariably independent predictor of worse clinical outcomes, while recipient positive cytomegalovirus serostatus and hematopoietic cell transplant comorbidity index &gt;3 were associated with worse OS and PFS. Our results suggest that younger donors may reduce the incidence of aGVHD and NRM, though at higher risk of relapse. A parent donor, particularly the mother, is not recommended in recipients ≤40 years." @default.
• W3064523218 created "2020-08-24" @default.
• W3064523218 creator A5002658796 @default.
• W3064523218 creator A5015429867 @default.
• W3064523218 creator A5018395647 @default.
• W3064523218 creator A5021041745 @default.
• W3064523218 creator A5021060422 @default.
• W3064523218 creator A5022161221 @default.
• W3064523218 creator A5023024318 @default.
• W3064523218 creator A5023466579 @default.
• W3064523218 creator A5023596964 @default.
• W3064523218 creator A5032955393 @default.
• W3064523218 creator A5034220119 @default.
• W3064523218 creator A5040794664 @default.
• W3064523218 creator A5042364382 @default.
• W3064523218 creator A5042424261 @default.
• W3064523218 creator A5043532080 @default.
• W3064523218 creator A5044096443 @default.
• W3064523218 creator A5047466242 @default.
• W3064523218 creator A5047791859 @default.
• W3064523218 creator A5049172299 @default.
• W3064523218 creator A5049668306 @default.
• W3064523218 creator A5055388096 @default.
• W3064523218 creator A5056256399 @default.
• W3064523218 creator A5057333997 @default.
• W3064523218 creator A5059403965 @default.
• W3064523218 creator A5069596141 @default.
• W3064523218 creator A5070767391 @default.
• W3064523218 creator A5074673843 @default.
• W3064523218 creator A5082045927 @default.
• W3064523218 creator A5082946230 @default.
• W3064523218 creator A5086116060 @default.
• W3064523218 creator A5091769198 @default.
• W3064523218 date "2020-08-19" @default.
• W3064523218 modified "2023-10-15" @default.
• W3064523218 title "Impact of donor age and kinship on clinical outcomes after T-cell–replete haploidentical transplantation with PT-Cy" @default.
• W3064523218 cites W1521169335 @default.
• W3064523218 cites W1817869068 @default.
• W3064523218 cites W1973617793 @default.
• W3064523218 cites W1976460197 @default.
• W3064523218 cites W1981542309 @default.
• W3064523218 cites W1997450401 @default.
• W3064523218 cites W2002547051 @default.
• W3064523218 cites W2005302631 @default.
• W3064523218 cites W2017908149 @default.
• W3064523218 cites W2019111335 @default.
• W3064523218 cites W2035057483 @default.
• W3064523218 cites W2038981426 @default.
• W3064523218 cites W2039334806 @default.
• W3064523218 cites W2059612196 @default.
• W3064523218 cites W2060578002 @default.
• W3064523218 cites W2072290737 @default.
• W3064523218 cites W2072435923 @default.
• W3064523218 cites W2074637790 @default.
• W3064523218 cites W2078916311 @default.
• W3064523218 cites W2116483603 @default.
• W3064523218 cites W2123365414 @default.
• W3064523218 cites W2128495370 @default.
• W3064523218 cites W2128812336 @default.
• W3064523218 cites W2140143467 @default.
• W3064523218 cites W2142493118 @default.
• W3064523218 cites W2152197116 @default.
• W3064523218 cites W2153491132 @default.
• W3064523218 cites W2307073326 @default.
• W3064523218 cites W2310252847 @default.
• W3064523218 cites W2337759633 @default.
• W3064523218 cites W2412214702 @default.
• W3064523218 cites W2520006964 @default.
• W3064523218 cites W2594745316 @default.
• W3064523218 cites W2618073389 @default.
• W3064523218 cites W2681369214 @default.
• W3064523218 cites W2755189167 @default.
• W3064523218 cites W2766315387 @default.
• W3064523218 cites W2767609948 @default.
• W3064523218 cites W2782603835 @default.
• W3064523218 cites W2783633607 @default.
• W3064523218 cites W2787765269 @default.
• W3064523218 cites W2788172857 @default.
• W3064523218 cites W2788411229 @default.
• W3064523218 cites W2907449476 @default.
• W3064523218 cites W2919180304 @default.
• W3064523218 cites W2972841168 @default.
• W3064523218 cites W3112391182 @default.
• W3064523218 cites W4293241248 @default.
• W3064523218 doi "https://doi.org/10.1182/bloodadvances.2020001620" @default.
• W3064523218 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7448598" @default.
• W3064523218 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32813875" @default.
• W3064523218 hasPublicationYear "2020" @default.
• W3064523218 type Work @default.
• W3064523218 sameAs 3064523218 @default.
• W3064523218 citedByCount "27" @default.
• W3064523218 countsByYear W30645232182020 @default.
• W3064523218 countsByYear W30645232182021 @default.
• W3064523218 countsByYear W30645232182022 @default.
• W3064523218 countsByYear W30645232182023 @default.
• W3064523218 crossrefType "journal-article" @default.
• W3064523218 hasAuthorship W3064523218A5002658796 @default.
• W3064523218 hasAuthorship W3064523218A5015429867 @default.

• next