FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3064869623> ?p ?o ?g. }

• W3064869623 endingPage "65.e11" @default.
• W3064869623 startingPage "65.e1" @default.
• W3064869623 abstract "Background Little has been reported to date on the instillation of antimicrobials directly into the bladder in children. Children with complex urinary tract anomalies struggle frequently with recurrent urinary tract infections (UTI), with frequent emergence of antibiotic resistance. Gentamicin bladder instillation to treat and prevent UTI was described in children since 2006. Objective We adopted gentamicin bladder instillation in 2016 and evaluate herein our intermediate-term experience with it. Study design and Methods This study is a retrospective review of a prospectively initiated database and a clinical audit of our practice. The gentamicin bladder instillation was employed in 24 cases. A treatment regime was initiated for symptomatic documented UTI when resistance patterns precluded an oral alternative (14 cases), avoiding hospitalisation for parenteral antibiotics. A prophylaxis regime (19 cases–including 9 of the 14 who received an initial treatment regime) followed at least one breakthrough UTI while receiving oral prophylactic antibiotics. Two instillation volumes (8 mg gentamicin in 20 mL 0.9% NaCl or 20 mg gentamicin in 50 mL 0.9% NaCl) were used to suit different bladder capacities. The irrigation is given twice a day for 7 days in the treatment regime or once a day, every other day, in the prophylactic regime. Gentamicin serum levels (all cases) and audiology/audiometry testing (17/24 cases) were checked to assess the safety of this method. Results The median age when either the treatment course or prophylaxis regime was started was 3.8 years. The treatment regime was 86% successful (12/14) to suppress an acute UTI. The mean duration of prophylaxis was 252 days (median: 256 days). The percentage of patients on the prophylactic regime who had no breakthrough UTI was 58%. No serum gentamicin was detectable secondary to the intravesical instillation. No attributable cases of sensorineural hearing loss were detected. Gentamicin resistance emerged in one case (4.16%). Discussion Intravesical administration was feasible via various routes for a spectrum of complex lower urinary tract abnormalities (see Summary Figure). Concerns regarding systemic absorption, nephrotoxicity or ototoxicity were investigated and safety ensured. Limitations include being a small series of non-identical pathologies, albeit categorically similar and being a single-arm study, however, statistical significance was proven descriptively and analytically. Conclusion Graphical AbstractUnderlying pathologies, bladder reconstruction, routes and regimes (protocols) used. View Large Image Figure Viewer Download Hi-res image" @default.
• W3064869623 created "2020-08-24" @default.
• W3064869623 creator A5055297543 @default.
• W3064869623 creator A5085753052 @default.
• W3064869623 creator A5088130504 @default.
• W3064869623 date "2021-02-01" @default.
• W3064869623 modified "2023-10-05" @default.
• W3064869623 title "Intravesical gentamicin instillation for the treatment and prevention of urinary tract infections in complex paediatric urology patients: evidence for safety and efficacy" @default.
• W3064869623 cites W107975464 @default.
• W3064869623 cites W1585063521 @default.
• W3064869623 cites W1985327068 @default.
• W3064869623 cites W1998459730 @default.
• W3064869623 cites W2001535729 @default.
• W3064869623 cites W2027162732 @default.
• W3064869623 cites W20525436 @default.
• W3064869623 cites W2062673463 @default.
• W3064869623 cites W2064578660 @default.
• W3064869623 cites W2072249031 @default.
• W3064869623 cites W2077289234 @default.
• W3064869623 cites W2104182801 @default.
• W3064869623 cites W2142869145 @default.
• W3064869623 cites W2156887055 @default.
• W3064869623 cites W2282385047 @default.
• W3064869623 cites W2317968346 @default.
• W3064869623 cites W2754560670 @default.
• W3064869623 cites W2768113853 @default.
• W3064869623 cites W2885490497 @default.
• W3064869623 cites W2904611213 @default.
• W3064869623 cites W30872940 @default.
• W3064869623 doi "https://doi.org/10.1016/j.jpurol.2020.08.007" @default.
• W3064869623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33309610" @default.
• W3064869623 hasPublicationYear "2021" @default.
• W3064869623 type Work @default.
• W3064869623 sameAs 3064869623 @default.
• W3064869623 citedByCount "11" @default.
• W3064869623 countsByYear W30648696232021 @default.
• W3064869623 countsByYear W30648696232022 @default.
• W3064869623 countsByYear W30648696232023 @default.
• W3064869623 crossrefType "journal-article" @default.
• W3064869623 hasAuthorship W3064869623A5055297543 @default.
• W3064869623 hasAuthorship W3064869623A5085753052 @default.
• W3064869623 hasAuthorship W3064869623A5088130504 @default.
• W3064869623 hasConcept C126322002 @default.
• W3064869623 hasConcept C126894567 @default.
• W3064869623 hasConcept C141071460 @default.
• W3064869623 hasConcept C2775832221 @default.
• W3064869623 hasConcept C2778602436 @default.
• W3064869623 hasConcept C2780026642 @default.
• W3064869623 hasConcept C501593827 @default.
• W3064869623 hasConcept C71924100 @default.
• W3064869623 hasConcept C77411442 @default.
• W3064869623 hasConcept C86803240 @default.
• W3064869623 hasConcept C89423630 @default.
• W3064869623 hasConceptScore W3064869623C126322002 @default.
• W3064869623 hasConceptScore W3064869623C126894567 @default.
• W3064869623 hasConceptScore W3064869623C141071460 @default.
• W3064869623 hasConceptScore W3064869623C2775832221 @default.
• W3064869623 hasConceptScore W3064869623C2778602436 @default.
• W3064869623 hasConceptScore W3064869623C2780026642 @default.
• W3064869623 hasConceptScore W3064869623C501593827 @default.
• W3064869623 hasConceptScore W3064869623C71924100 @default.
• W3064869623 hasConceptScore W3064869623C77411442 @default.
• W3064869623 hasConceptScore W3064869623C86803240 @default.
• W3064869623 hasConceptScore W3064869623C89423630 @default.
• W3064869623 hasIssue "1" @default.
• W3064869623 hasLocation W30648696231 @default.
• W3064869623 hasOpenAccess W3064869623 @default.
• W3064869623 hasPrimaryLocation W30648696231 @default.
• W3064869623 hasRelatedWork W157111719 @default.
• W3064869623 hasRelatedWork W1994263115 @default.
• W3064869623 hasRelatedWork W2013508761 @default.
• W3064869623 hasRelatedWork W2025722779 @default.
• W3064869623 hasRelatedWork W2060578086 @default.
• W3064869623 hasRelatedWork W2066241710 @default.
• W3064869623 hasRelatedWork W2336206380 @default.
• W3064869623 hasRelatedWork W2983014931 @default.
• W3064869623 hasRelatedWork W4210649894 @default.
• W3064869623 hasRelatedWork W4311417406 @default.
• W3064869623 hasVolume "17" @default.
• W3064869623 isParatext "false" @default.
• W3064869623 isRetracted "false" @default.
• W3064869623 magId "3064869623" @default.
• W3064869623 workType "article" @default.