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- W3065158538 abstract "Inhibition of glycogen synthase kinase 3β (GSK-3β) with SB 216763 attenuates delayed gastric emptying through gastric nuclear factor erythroid 2-related factor 2 (Nrf2) -phase II enzymes in high-fat diet-fed female mice. SB 216763 restored impaired gastric PI3K/AKT/ β-catenin/caspase 3 expression. Inhibition of GSK-3β normalized gastric dihydrofolate reductase, neuronal nitric oxide synthase-α expression, dimerization and nitrergic relaxation. SB 216763 normalized both serum estrogen and nitrate levels in female obese/Type 2 diabetes mice. SB 216763 reduced downstream signaling of GSK-3β in enteric neuronal cells in vitro." @default.
- W3065158538 created "2020-08-24" @default.
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- W3065158538 date "2020-10-01" @default.
- W3065158538 modified "2023-10-16" @default.
- W3065158538 title "Inhibition of GSK-3β restores delayed gastric emptying in obesity-induced diabetic female mice" @default.
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- W3065158538 doi "https://doi.org/10.1152/ajpgi.00227.2020" @default.
- W3065158538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7654647" @default.
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