FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3065608340> ?p ?o ?g. }

• W3065608340 endingPage "12685" @default.
• W3065608340 startingPage "12678" @default.
• W3065608340 abstract "γ-Glutamyl transpeptidase (GGT), a cell surface-bound protease, is associated with various diseases including cancer. The detection of the enzyme activity is an important subject, leading to about 40 activatable fluorescent probes so far. All of them, however, lack the membrane-localizing ability, raising a reliability issue in the quantitative analysis. Disclosed is the first fluorescent probe that senses the cell surface-bound enzyme, which, furthermore, is capable of ratiometric as well as two-photon imaging with desirable features. Ratiometric imaging of cancer cell lines reveals a 6.4–8.4-fold higher GGT levels than those in normal cell lines. A comparison of the enzyme activity in organ tissues of normal and tumor xenograft mice reveals notably different levels of enzyme activity depending on the kind of tissue. Normal tissues exhibited comparable levels of enzyme activity, except the kidney that has significantly higher GGT activity (2.7–4.0-fold) than the other organs. Compared with the normal tissues, considerably higher enzyme activity was observed in the tumor tissues of the thigh (4.0-fold), colon (2.5-fold), lung (3.6-fold), and liver (2.1-fold), but essentially no enhanced activity in the tumor tissues of the spleen, stomach, and pancreas and a comparable level in both the tumor and normal kidney tissues were observed. The probe offers practical means for studying GGT-associated biology in cells and tissues by one- as well as two-photon ratiometric imaging." @default.
• W3065608340 created "2020-08-24" @default.
• W3065608340 creator A5027861014 @default.
• W3065608340 creator A5055280723 @default.
• W3065608340 creator A5055602514 @default.
• W3065608340 creator A5059543998 @default.
• W3065608340 date "2020-08-18" @default.
• W3065608340 modified "2023-10-14" @default.
• W3065608340 title "Cell-Membrane-Localizing, Two-Photon Probe for Ratiometric Imaging of γ-Glutamyl Transpeptidase in Cancerous Cells and Tissues" @default.
• W3065608340 cites W1967165702 @default.
• W3065608340 cites W1967652154 @default.
• W3065608340 cites W1982101277 @default.
• W3065608340 cites W1990683013 @default.
• W3065608340 cites W2001278314 @default.
• W3065608340 cites W2012156151 @default.
• W3065608340 cites W2012838605 @default.
• W3065608340 cites W2032913011 @default.
• W3065608340 cites W2037098558 @default.
• W3065608340 cites W2043670542 @default.
• W3065608340 cites W2047622488 @default.
• W3065608340 cites W2058041021 @default.
• W3065608340 cites W2071948096 @default.
• W3065608340 cites W2076388276 @default.
• W3065608340 cites W2095210131 @default.
• W3065608340 cites W2095608650 @default.
• W3065608340 cites W2098470100 @default.
• W3065608340 cites W2109235556 @default.
• W3065608340 cites W2165323450 @default.
• W3065608340 cites W2291114788 @default.
• W3065608340 cites W2436923789 @default.
• W3065608340 cites W2470172036 @default.
• W3065608340 cites W2481699162 @default.
• W3065608340 cites W2568205563 @default.
• W3065608340 cites W2572044644 @default.
• W3065608340 cites W2590710686 @default.
• W3065608340 cites W2604393025 @default.
• W3065608340 cites W2614798891 @default.
• W3065608340 cites W2754315112 @default.
• W3065608340 cites W2769804757 @default.
• W3065608340 cites W2784321926 @default.
• W3065608340 cites W2787330884 @default.
• W3065608340 cites W2788216262 @default.
• W3065608340 cites W2806065664 @default.
• W3065608340 cites W2894732085 @default.
• W3065608340 cites W2902260267 @default.
• W3065608340 cites W2903967942 @default.
• W3065608340 cites W2949869073 @default.
• W3065608340 cites W2952309100 @default.
• W3065608340 cites W2978637532 @default.
• W3065608340 cites W3017090599 @default.
• W3065608340 cites W3021981632 @default.
• W3065608340 cites W4254120012 @default.
• W3065608340 doi "https://doi.org/10.1021/acs.analchem.0c03013" @default.
• W3065608340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32808765" @default.
• W3065608340 hasPublicationYear "2020" @default.
• W3065608340 type Work @default.
• W3065608340 sameAs 3065608340 @default.
• W3065608340 citedByCount "26" @default.
• W3065608340 countsByYear W30656083402020 @default.
• W3065608340 countsByYear W30656083402021 @default.
• W3065608340 countsByYear W30656083402022 @default.
• W3065608340 countsByYear W30656083402023 @default.
• W3065608340 crossrefType "journal-article" @default.
• W3065608340 hasAuthorship W3065608340A5027861014 @default.
• W3065608340 hasAuthorship W3065608340A5055280723 @default.
• W3065608340 hasAuthorship W3065608340A5055602514 @default.
• W3065608340 hasAuthorship W3065608340A5059543998 @default.
• W3065608340 hasConcept C121332964 @default.
• W3065608340 hasConcept C121608353 @default.
• W3065608340 hasConcept C12554922 @default.
• W3065608340 hasConcept C134018914 @default.
• W3065608340 hasConcept C1491633281 @default.
• W3065608340 hasConcept C153911025 @default.
• W3065608340 hasConcept C181199279 @default.
• W3065608340 hasConcept C185592680 @default.
• W3065608340 hasConcept C2778106830 @default.
• W3065608340 hasConcept C2778764654 @default.
• W3065608340 hasConcept C2780091579 @default.
• W3065608340 hasConcept C28212737 @default.
• W3065608340 hasConcept C47785574 @default.
• W3065608340 hasConcept C54355233 @default.
• W3065608340 hasConcept C55493867 @default.
• W3065608340 hasConcept C62520636 @default.
• W3065608340 hasConcept C81885089 @default.
• W3065608340 hasConcept C86803240 @default.
• W3065608340 hasConcept C91881484 @default.
• W3065608340 hasConcept C96232424 @default.
• W3065608340 hasConceptScore W3065608340C121332964 @default.
• W3065608340 hasConceptScore W3065608340C121608353 @default.
• W3065608340 hasConceptScore W3065608340C12554922 @default.
• W3065608340 hasConceptScore W3065608340C134018914 @default.
• W3065608340 hasConceptScore W3065608340C1491633281 @default.
• W3065608340 hasConceptScore W3065608340C153911025 @default.
• W3065608340 hasConceptScore W3065608340C181199279 @default.
• W3065608340 hasConceptScore W3065608340C185592680 @default.
• W3065608340 hasConceptScore W3065608340C2778106830 @default.
• W3065608340 hasConceptScore W3065608340C2778764654 @default.
• W3065608340 hasConceptScore W3065608340C2780091579 @default.

• next