FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3065741572> ?p ?o ?g. }

• W3065741572 abstract "Abstract Despite their emerging relevance to fully understand disease pathogenesis, we have as yet a poor understanding as to how biomechanical signals are integrated with specific biochemical pathways to determine cell behaviour. Mesothelial-to-mesenchymal transition (MMT) markers colocalized with TGF-β1-dependent signaling and yes-associated protein (YAP) activation across biopsies from different pathologies exhibiting peritoneal fibrosis, supporting mechanotransduction as a central driving component of these class of fibrotic lesions and its crosstalk with specific signaling pathways. Transcriptome and proteome profiling of the response of mesothelial cells (MCs) to linear cyclic stretch revealed molecular changes compatible with bona fide MMT, which (i) overlapped with established YAP target gene subsets, and were largely dependent on endogenous TGF-β1 signaling. Importantly, TGF-β1 blockade blunts the transcriptional upregulation of these gene signatures, but not the mechanical activation and nuclear translocation of YAP per se. We studied the role therein of caveolin-1 (CAV1), a plasma membrane mechanotransducer. Exposure of CAV1-deficient MCs to cyclic stretch led to a robust upregulation of MMT-related gene programs, which was blunted upon TGF-β1 inhibition. Conversely, CAV1 depletion enhanced both TGF-β1 and TGFBRI expression, whereas its re-expression blunted mechanical stretching-induced MMT. CAV1 genetic deficiency exacerbated MMT and adhesion formation in an experimental murine model of peritoneal ischaemic buttons. Taken together, these results support that CAV1-YAP/TAZ fine-tune the fibrotic response through the modulation of MMT, onto which TGF-β1-dependent signaling coordinately converges. Our findings reveal a cooperation between biomechanical and biochemical signals in the triggering of MMT, representing a novel potential opportunity to intervene mechanically induced disorders coursing with peritoneal fibrosis, such as post-surgical adhesions." @default.
• W3065741572 created "2020-08-24" @default.
• W3065741572 creator A5000451168 @default.
• W3065741572 creator A5000572178 @default.
• W3065741572 creator A5006987199 @default.
• W3065741572 creator A5014621950 @default.
• W3065741572 creator A5014894185 @default.
• W3065741572 creator A5015419512 @default.
• W3065741572 creator A5017097584 @default.
• W3065741572 creator A5017329858 @default.
• W3065741572 creator A5022441204 @default.
• W3065741572 creator A5033161729 @default.
• W3065741572 creator A5053531262 @default.
• W3065741572 creator A5054363798 @default.
• W3065741572 creator A5056380260 @default.
• W3065741572 creator A5056654136 @default.
• W3065741572 creator A5061401583 @default.
• W3065741572 creator A5065735989 @default.
• W3065741572 creator A5081217694 @default.
• W3065741572 creator A5081222322 @default.
• W3065741572 date "2020-08-03" @default.
• W3065741572 modified "2023-10-18" @default.
• W3065741572 title "Caveolin1 and YAP drive mechanically induced mesothelial to mesenchymal transition and fibrosis" @default.
• W3065741572 cites W1894821366 @default.
• W3065741572 cites W1968409252 @default.
• W3065741572 cites W1987315175 @default.
• W3065741572 cites W1995160678 @default.
• W3065741572 cites W2002594335 @default.
• W3065741572 cites W2023468848 @default.
• W3065741572 cites W2028453113 @default.
• W3065741572 cites W2036897871 @default.
• W3065741572 cites W2041218928 @default.
• W3065741572 cites W2044339772 @default.
• W3065741572 cites W2065323571 @default.
• W3065741572 cites W2065522670 @default.
• W3065741572 cites W2068310937 @default.
• W3065741572 cites W2068972539 @default.
• W3065741572 cites W2068982132 @default.
• W3065741572 cites W2074243960 @default.
• W3065741572 cites W2078704533 @default.
• W3065741572 cites W2080442169 @default.
• W3065741572 cites W2088876544 @default.
• W3065741572 cites W2098692163 @default.
• W3065741572 cites W2099094020 @default.
• W3065741572 cites W2100837269 @default.
• W3065741572 cites W2100842035 @default.
• W3065741572 cites W2106141385 @default.
• W3065741572 cites W2111833940 @default.
• W3065741572 cites W2114104545 @default.
• W3065741572 cites W2135726634 @default.
• W3065741572 cites W2139803981 @default.
• W3065741572 cites W2143908642 @default.
• W3065741572 cites W2146337514 @default.
• W3065741572 cites W2150163671 @default.
• W3065741572 cites W2154410358 @default.
• W3065741572 cites W2167978765 @default.
• W3065741572 cites W2168072233 @default.
• W3065741572 cites W2184722934 @default.
• W3065741572 cites W2262921329 @default.
• W3065741572 cites W2295717665 @default.
• W3065741572 cites W2302589752 @default.
• W3065741572 cites W2304308035 @default.
• W3065741572 cites W2313102331 @default.
• W3065741572 cites W2525683625 @default.
• W3065741572 cites W2549070824 @default.
• W3065741572 cites W2558804565 @default.
• W3065741572 cites W2592660965 @default.
• W3065741572 cites W2602916090 @default.
• W3065741572 cites W2737029830 @default.
• W3065741572 cites W2765939774 @default.
• W3065741572 cites W2785005715 @default.
• W3065741572 cites W2793865924 @default.
• W3065741572 cites W2803559577 @default.
• W3065741572 cites W2893019622 @default.
• W3065741572 cites W2899197921 @default.
• W3065741572 cites W2899756901 @default.
• W3065741572 cites W2902933296 @default.
• W3065741572 cites W2908013762 @default.
• W3065741572 cites W2945193235 @default.
• W3065741572 cites W2949673162 @default.
• W3065741572 cites W2955418269 @default.
• W3065741572 cites W3006905621 @default.
• W3065741572 cites W4211233744 @default.
• W3065741572 cites W4250450758 @default.
• W3065741572 doi "https://doi.org/10.1038/s41419-020-02822-1" @default.
• W3065741572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7435273" @default.
• W3065741572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32811813" @default.
• W3065741572 hasPublicationYear "2020" @default.
• W3065741572 type Work @default.
• W3065741572 sameAs 3065741572 @default.
• W3065741572 citedByCount "36" @default.
• W3065741572 countsByYear W30657415722020 @default.
• W3065741572 countsByYear W30657415722021 @default.
• W3065741572 countsByYear W30657415722022 @default.
• W3065741572 countsByYear W30657415722023 @default.
• W3065741572 crossrefType "journal-article" @default.
• W3065741572 hasAuthorship W3065741572A5000451168 @default.
• W3065741572 hasAuthorship W3065741572A5000572178 @default.
• W3065741572 hasAuthorship W3065741572A5006987199 @default.
• W3065741572 hasAuthorship W3065741572A5014621950 @default.

• next