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- W3066271738 abstract "Significance Many neurological disorders stem from damage to myelin, the insulating material which wraps around nerves and provides optimal nerve conduction. We previously found that IL-33, a chemical made in response to injury, was able to induce new myelin formation. In exploring compounds which can induce IL-33, we found that anacardic acid, a compound found in the plant kingdom, was able to promote the formation of new myelin. In addition, treatment of mice with anacardic acid induced IL-33 in the nervous system and resulted in reduced injury in animal models of disease in which loss of myelin was experimentally induced. We believe that the actions of anacardic acid warrants further study for the treatment of demyelinating diseases." @default.
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- W3066271738 date "2020-08-17" @default.
- W3066271738 modified "2023-10-11" @default.
- W3066271738 title "Anacardic acid induces IL-33 and promotes remyelination in CNS" @default.
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- W3066271738 doi "https://doi.org/10.1073/pnas.2006566117" @default.
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