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• W3066297032 abstract "Abstract Targeted drug delivery system can reduce the side effects of high drug concentration by improving drug pharmacokinetics at lower doses. Citrate-gold nanoparticles (AuNPs) as a drug delivery system were synthesized via green nanotechnology technique to be used as a new imaging platform for tumor targeting. Citrate-AuNPs were synthesized with core size of 10 nm. Citrate-AuNPs were labeled with technetium-99m ( 99m Tc) with radiochemical yield of 95.20 ± 2.70% with good in-vitro stability in both saline and human serum and well in-vivo studied in both normal and solid tumor bearing mice. The in-vivo biodistribution study of [ 99m Tc]Tc-citrate-AuNPs in solid tumor bearing mice (as preliminary study) showed a high accumulation in tumor site with tumor/muscle of 4.35 ± 0.22 after 30 min post injection. The direct intratumoral (I.T) injection of [ 99m Tc]Tc-citrate-AuNPs showed that this complex was retained in the tumor up to 77.86 ± 1.90 % at 5 min and still around 50.00 ± 1.42 % after 30 min post injection (p.i.). The newly presented nano-platform could be presented as a new potential radiopharmaceutical tumor imaging probe." @default.
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• W3066297032 date "2020-08-12" @default.
• W3066297032 modified "2023-09-24" @default.
• W3066297032 title "^99mTc-citrate-gold nanoparticles as a tumor tracer: synthesis, characterization, radiolabeling and <i>in-vivo</i> studies" @default.
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• W3066297032 doi "https://doi.org/10.1515/ract-2019-3208" @default.
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