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- W3066361405 abstract "Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since. Here we revisit the proteome of myelin biochemically purified from the brains of healthy c56Bl/6N-mice utilizing complementary proteomic approaches for deep qualitative and quantitative coverage. By gel-free, label-free mass spectrometry, the most abundant myelin proteins PLP, MBP, CNP, and MOG constitute 38, 30, 5, and 1% of the total myelin protein, respectively. The relative abundance of myelin proteins displays a dynamic range of over four orders of magnitude, implying that PLP and MBP have overshadowed less abundant myelin constituents in initial gel-based approaches. By comparisons with published datasets we evaluate to which degree the CNS myelin proteome correlates with the mRNA and protein abundance profiles of myelin and oligodendrocytes. Notably, the myelin proteome displays only minor changes if assessed after a post-mortem delay of 6 h. These data provide the most comprehensive proteome resource of CNS myelin so far and a basis for addressing proteomic heterogeneity of myelin in mouse models and human patients with white matter disorders." @default.
- W3066361405 created "2020-08-24" @default.
- W3066361405 creator A5030117023 @default.
- W3066361405 creator A5032116473 @default.
- W3066361405 creator A5034886058 @default.
- W3066361405 creator A5044498878 @default.
- W3066361405 creator A5048421376 @default.
- W3066361405 creator A5064614134 @default.
- W3066361405 creator A5064777130 @default.
- W3066361405 creator A5083362155 @default.
- W3066361405 creator A5084358834 @default.
- W3066361405 date "2020-08-19" @default.
- W3066361405 modified "2023-10-18" @default.
- W3066361405 title "The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay" @default.
- W3066361405 cites W1501023047 @default.
- W3066361405 cites W1608737740 @default.
- W3066361405 cites W1652241690 @default.
- W3066361405 cites W1839988640 @default.
- W3066361405 cites W1922804481 @default.
- W3066361405 cites W1942044918 @default.
- W3066361405 cites W1955394435 @default.
- W3066361405 cites W1971295712 @default.
- W3066361405 cites W1976590415 @default.
- W3066361405 cites W1977260469 @default.
- W3066361405 cites W1979283544 @default.
- W3066361405 cites W1981443842 @default.
- W3066361405 cites W1983080072 @default.
- W3066361405 cites W1984067392 @default.
- W3066361405 cites W1984460442 @default.
- W3066361405 cites W1986887325 @default.
- W3066361405 cites W1994261045 @default.
- W3066361405 cites W1995139758 @default.
- W3066361405 cites W1995763269 @default.
- W3066361405 cites W1997522187 @default.
- W3066361405 cites W2000485285 @default.
- W3066361405 cites W2001321742 @default.
- W3066361405 cites W2002533741 @default.
- W3066361405 cites W2007952700 @default.
- W3066361405 cites W2008214517 @default.
- W3066361405 cites W2009808755 @default.
- W3066361405 cites W2011061591 @default.
- W3066361405 cites W2012506738 @default.
- W3066361405 cites W2013910899 @default.
- W3066361405 cites W2016669072 @default.
- W3066361405 cites W2016767264 @default.
- W3066361405 cites W2023367024 @default.
- W3066361405 cites W2024102509 @default.
- W3066361405 cites W2028617079 @default.
- W3066361405 cites W2030349992 @default.
- W3066361405 cites W2033268373 @default.
- W3066361405 cites W2034844685 @default.
- W3066361405 cites W2036567890 @default.
- W3066361405 cites W2036688360 @default.
- W3066361405 cites W2040120130 @default.
- W3066361405 cites W2041165891 @default.
- W3066361405 cites W2047031974 @default.
- W3066361405 cites W2047845962 @default.
- W3066361405 cites W2048436941 @default.
- W3066361405 cites W2050964449 @default.
- W3066361405 cites W2053632281 @default.
- W3066361405 cites W2054275187 @default.
- W3066361405 cites W2057866108 @default.
- W3066361405 cites W2059487035 @default.
- W3066361405 cites W2061271326 @default.
- W3066361405 cites W2064253207 @default.
- W3066361405 cites W2066138347 @default.
- W3066361405 cites W2080069132 @default.
- W3066361405 cites W2082018654 @default.
- W3066361405 cites W2083198066 @default.
- W3066361405 cites W2083334063 @default.
- W3066361405 cites W2086192510 @default.
- W3066361405 cites W2094520476 @default.
- W3066361405 cites W2095208158 @default.
- W3066361405 cites W2098744846 @default.
- W3066361405 cites W2113019415 @default.
- W3066361405 cites W2116747568 @default.
- W3066361405 cites W2119216843 @default.
- W3066361405 cites W2122914905 @default.
- W3066361405 cites W2124088653 @default.
- W3066361405 cites W2126629775 @default.
- W3066361405 cites W2141360872 @default.
- W3066361405 cites W2151814085 @default.
- W3066361405 cites W2152492028 @default.
- W3066361405 cites W2152770371 @default.
- W3066361405 cites W2166043619 @default.
- W3066361405 cites W2168213636 @default.
- W3066361405 cites W2170422221 @default.
- W3066361405 cites W2235756907 @default.
- W3066361405 cites W2257936017 @default.
- W3066361405 cites W2287180374 @default.
- W3066361405 cites W2298231951 @default.
- W3066361405 cites W2308569764 @default.
- W3066361405 cites W2315952645 @default.
- W3066361405 cites W2351007730 @default.
- W3066361405 cites W2415341492 @default.
- W3066361405 cites W2475961050 @default.
- W3066361405 cites W2488973906 @default.
- W3066361405 cites W2568303975 @default.
- W3066361405 cites W2587552705 @default.
- W3066361405 cites W2728207433 @default.