Matches in SemOpenAlex for { <https://semopenalex.org/work/W3066539718> ?p ?o ?g. }
- W3066539718 abstract "Abstract Swarming is a form of collective bacterial motion enabled by flagella on the surface of semi-solid media. Swarming populations exhibit non-genetic or adaptive resistance to antibiotics, despite sustaining considerable cell death. Here, we show that antibiotic-induced death of a sub-population benefits the swarm by enhancing adaptive resistance in the surviving cells. Killed cells release a resistance-enhancing factor that we identify as AcrA, a periplasmic component of RND efflux pumps. The released AcrA interacts on the surface of live cells with an outer membrane component of the efflux pump, TolC, stimulating drug efflux and inducing expression of other efflux pumps. This phenomenon, which we call ‘necrosignaling’, exists in other Gram-negative and Gram-positive bacteria and displays species-specificity. Given that adaptive resistance is a known incubator for evolving genetic resistance, our findings might be clinically relevant to the rise of multidrug resistance." @default.
- W3066539718 created "2020-08-24" @default.
- W3066539718 creator A5033548516 @default.
- W3066539718 creator A5049473122 @default.
- W3066539718 creator A5061931498 @default.
- W3066539718 date "2020-08-19" @default.
- W3066539718 modified "2023-10-03" @default.
- W3066539718 title "Dead cells release a ‘necrosignal’ that activates antibiotic survival pathways in bacterial swarms" @default.
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- W3066539718 doi "https://doi.org/10.1038/s41467-020-17709-0" @default.
- W3066539718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7438516" @default.
- W3066539718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32814767" @default.
- W3066539718 hasPublicationYear "2020" @default.
- W3066539718 type Work @default.