FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3067009413> ?p ?o ?g. }

• W3067009413 endingPage "617" @default.
• W3067009413 startingPage "612" @default.
• W3067009413 abstract "Single-cell RNA sequencing of embryos can resolve the transcriptional landscape of development at unprecedented resolution. To date, single-cell RNA-sequencing studies of mammalian embryos have focused exclusively on eutherian species. Analysis of mammalian outgroups has the potential to identify deeply conserved lineage specification and pluripotency factors, and can extend our understanding of X dosage compensation. Metatherian (marsupial) mammals diverged from eutherians around 160 million years ago. They exhibit distinctive developmental features, including late implantation1 and imprinted X chromosome inactivation2, which is associated with expression of the XIST-like noncoding RNA RSX3. Here we perform a single-cell RNA-sequencing analysis of embryogenesis and X chromosome inactivation in a marsupial, the grey short-tailed opossum (Monodelphis domestica). We resolve the developmental trajectory and transcriptional signatures of the epiblast, primitive endoderm and trophectoderm, and identify deeply conserved lineage-specific markers that pre-date the eutherian–marsupial divergence. RSX coating and inactivation of the X chromosome occurs early and rapidly. This observation supports the hypothesis that—in organisms with early X chromosome inactivation—imprinted X chromosome inactivation prevents biallelic X silencing. We identify XSR, an RSX antisense transcript expressed from the active X chromosome, as a candidate for the regulator of imprinted X chromosome inactivation. Our datasets provide insights into the evolution of mammalian embryogenesis and X dosage compensation. Single-cell RNA-sequencing analysis of embryogenesis and X chromosome inactivation in the opossum (Monodelphis domestica) resolves the developmental trajectory of a marsupial, and sheds light on the evolution of embryogenesis in mammals." @default.
• W3067009413 created "2020-08-24" @default.
• W3067009413 creator A5026072466 @default.
• W3067009413 creator A5057467621 @default.
• W3067009413 creator A5087530257 @default.
• W3067009413 creator A5090611498 @default.
• W3067009413 date "2020-08-19" @default.
• W3067009413 modified "2023-10-03" @default.
• W3067009413 title "A single-cell transcriptome atlas of marsupial embryogenesis and X inactivation" @default.
• W3067009413 cites W1671825979 @default.
• W3067009413 cites W1901132147 @default.
• W3067009413 cites W1966474833 @default.
• W3067009413 cites W1966758700 @default.
• W3067009413 cites W1978420996 @default.
• W3067009413 cites W1978578392 @default.
• W3067009413 cites W1979862010 @default.
• W3067009413 cites W1981088384 @default.
• W3067009413 cites W1981301360 @default.
• W3067009413 cites W1984883254 @default.
• W3067009413 cites W1985658425 @default.
• W3067009413 cites W1987583896 @default.
• W3067009413 cites W1994144105 @default.
• W3067009413 cites W2004618496 @default.
• W3067009413 cites W2012305943 @default.
• W3067009413 cites W2012844246 @default.
• W3067009413 cites W2024594915 @default.
• W3067009413 cites W2036454804 @default.
• W3067009413 cites W2053187427 @default.
• W3067009413 cites W2053482584 @default.
• W3067009413 cites W2054266967 @default.
• W3067009413 cites W2056156549 @default.
• W3067009413 cites W2073286325 @default.
• W3067009413 cites W2076838302 @default.
• W3067009413 cites W2078745343 @default.
• W3067009413 cites W2082384965 @default.
• W3067009413 cites W2090390436 @default.
• W3067009413 cites W2093466316 @default.
• W3067009413 cites W2096736856 @default.
• W3067009413 cites W2097468611 @default.
• W3067009413 cites W2104005232 @default.
• W3067009413 cites W2107011634 @default.
• W3067009413 cites W2107611498 @default.
• W3067009413 cites W2112135073 @default.
• W3067009413 cites W2112816839 @default.
• W3067009413 cites W2125336256 @default.
• W3067009413 cites W2126851387 @default.
• W3067009413 cites W2129957319 @default.
• W3067009413 cites W2130273514 @default.
• W3067009413 cites W2130743364 @default.
• W3067009413 cites W2137874965 @default.
• W3067009413 cites W2142330433 @default.
• W3067009413 cites W2146095627 @default.
• W3067009413 cites W2149771342 @default.
• W3067009413 cites W2156653121 @default.
• W3067009413 cites W2171756746 @default.
• W3067009413 cites W2316095770 @default.
• W3067009413 cites W2418928349 @default.
• W3067009413 cites W2510875395 @default.
• W3067009413 cites W2517993048 @default.
• W3067009413 cites W2561883112 @default.
• W3067009413 cites W2582005133 @default.
• W3067009413 cites W2582033455 @default.
• W3067009413 cites W2618900678 @default.
• W3067009413 cites W2619140115 @default.
• W3067009413 cites W2759601393 @default.
• W3067009413 cites W2765099814 @default.
• W3067009413 cites W2766730109 @default.
• W3067009413 cites W2794480084 @default.
• W3067009413 cites W2890901412 @default.
• W3067009413 cites W4232117151 @default.
• W3067009413 cites W4244203357 @default.
• W3067009413 doi "https://doi.org/10.1038/s41586-020-2629-6" @default.
• W3067009413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7116401" @default.
• W3067009413 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32814901" @default.
• W3067009413 hasPublicationYear "2020" @default.
• W3067009413 type Work @default.
• W3067009413 sameAs 3067009413 @default.
• W3067009413 citedByCount "29" @default.
• W3067009413 countsByYear W30670094132020 @default.
• W3067009413 countsByYear W30670094132021 @default.
• W3067009413 countsByYear W30670094132022 @default.
• W3067009413 countsByYear W30670094132023 @default.
• W3067009413 crossrefType "journal-article" @default.
• W3067009413 hasAuthorship W3067009413A5026072466 @default.
• W3067009413 hasAuthorship W3067009413A5057467621 @default.
• W3067009413 hasAuthorship W3067009413A5087530257 @default.
• W3067009413 hasAuthorship W3067009413A5090611498 @default.
• W3067009413 hasBestOaLocation W30670094132 @default.
• W3067009413 hasConcept C104317684 @default.
• W3067009413 hasConcept C105702510 @default.
• W3067009413 hasConcept C110411900 @default.
• W3067009413 hasConcept C129536746 @default.
• W3067009413 hasConcept C150194340 @default.
• W3067009413 hasConcept C151730666 @default.
• W3067009413 hasConcept C162317418 @default.
• W3067009413 hasConcept C190727270 @default.
• W3067009413 hasConcept C196843134 @default.
• W3067009413 hasConcept C201492766 @default.

• next