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- W30684406 endingPage "404" @default.
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- W30684406 abstract "Antiarrhythmic agents play an important role in the termination and suppression of both atrial and ventricular arrhythmias as primary or adjunctive therapy. The use of hybrid treatment, combining drugs with radiofrequency ablation or ICD implantation, is expected to rise as the number of patients with complex arrhythmias continues to increase (1,2). In this evolving management scenario, selection of an effective yet safe pharmacologic agent is challenging. The challenge arises from factors intrinsic to the patient, disease condition or the drug itself. These factors primarily include variability in the pathophysiologic substrate, diverse arrhythmia mechanisms, multiple clinical presentation with differing prognostic implications, along with variability in drug disposition and/or response in a highly heterogeneous patient population. Moreover, the availability of multiple therapeutic options and the narrow therapeutic index with limited ability to determine satisfactory endpoints further emphasize the need for better understanding of interactions between drug, end target, and disease condition." @default.
- W30684406 created "2016-06-24" @default.
- W30684406 creator A5009525294 @default.
- W30684406 creator A5010500199 @default.
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- W30684406 date "2003-01-01" @default.
- W30684406 modified "2023-10-18" @default.
- W30684406 title "Antiarrhythmic Drugs and Future Direction" @default.
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