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• W3069792111 abstract "ARAF is a member of the RAF kinase family that is necessary for mitogen-activated protein kinase (MAPK) activation in various malignancies, including lung, colorectal, pancreatic, and breast cancers. As the most common biliary tract tumor, gallbladder cancer (GBC) seriously harms human health while the function of ARAF in GBC remains elusive. Here, we found that ARAF expression was upregulated in gallbladder cancer tissues. In vitro , ARAF silencing mediated by RNA interference effectively inhibited cell proliferation, colony formation, migration, and invasion of GBC cells. Moreover, knocking down ARAF suppressed tumor growth in vivo . Our results indicated that ARAF functions as an oncogene in GBC and, thus, could be a potential therapeutic target for GBC." @default.
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• W3069792111 date "2020-08-19" @default.
• W3069792111 modified "2023-10-17" @default.
• W3069792111 title "Silencing ARAF Suppresses the Malignant Phenotypes of Gallbladder Cancer Cells" @default.
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• W3069792111 doi "https://doi.org/10.1155/2020/3235786" @default.
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