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- W3070825530 abstract "An l-amino acid oxidase (LAO) is an amino acid metabolism enzyme that also performs a variety of biological activities. Recently, LAOs have been discovered to be deeply involved in innate immunity in fish because of their antibacterial and antiparasitic activity. The determinant of potent antibacterial/antiparasitic activity is the H2O2 byproduct of LAO enzymatic activity that utilizes the l-amino acid as a substrate. In addition, fish LAOs are upregulated by pathogenic bacteria or parasite infection. Furthermore, some fish LAOs show that the target specificity depends on the virulence of the bacteria. All results reflect that LAOs are new innate immune molecules. This review also describes the potential of the immunomodulatory functions of fish LAOs, not only the innate immune function by a direct oxidation attack of H2O2." @default.
- W3070825530 created "2020-08-24" @default.
- W3070825530 creator A5026355017 @default.
- W3070825530 creator A5041329480 @default.
- W3070825530 date "2020-11-01" @default.
- W3070825530 modified "2023-10-16" @default.
- W3070825530 title "l-Amino acid oxidase as a fish host-defense molecule" @default.
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- W3070825530 doi "https://doi.org/10.1016/j.fsi.2020.08.028" @default.
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