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- W3071125008 abstract "A novel P(NMe2)3-mediated tandem (1 + 4) annulation between aroylformates and δ-tosylamino enones has been developed that affords a facile synthesis of functionalized pyrrolidines in moderate to excellent yields with exclusive chemoselectivity and high diastereoselectivity. Mechanistic investigation reveals that the reaction proceeds through an unprecedented P(NMe2)3-mediated reductive amination/base-catalyzed Michael addition cascade. The reaction herein also represents the first study of the reactivity patterns of the Kukhtin-Ramirez adducts toward ambiphilic nucleophile-electrophiles." @default.
- W3071125008 created "2020-08-24" @default.
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- W3071125008 date "2020-08-18" @default.
- W3071125008 modified "2023-10-15" @default.
- W3071125008 title "Chemo- and Diastereoselective Synthesis of Pyrrolidines from Aroylformates and δ-Tosylamino Enones via P(NMe<sub>2</sub>)<sub>3</sub>-Mediated Reductive Amination/Base-Catalyzed Michael Addition Cascade" @default.
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- W3071125008 doi "https://doi.org/10.1021/acs.orglett.0c02453" @default.
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