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- W307112592 abstract "Structural imaging suggests that traumatic brain injury (TBI) may be associated with disruption of neuronal networks, including the nigrostriatal dopami- nergic pathway. However, to date deficits in pre- and/or postsynaptic dopaminergic neurotransmission have not been demonstrated in TBI using functional imaging. We therefore assessed dopaminergic function in ten TBI patients using ( 123 I)2-β-carbomethoxy-3-β-(4-iodophe- nyl)tropane (β-CIT) and ( 123 I)iodobenzamide (IBZM) single-photon emission tomography (SPET). Average Glasgow Coma Scale score (±SD) at the time of head trauma was 5.8±4.2. SPET was performed on average 141 days (SD ±92) after TBI. The SPET images were compared with structural images using cranial comput- erised tomography (CCT) and magnetic resonance imag- ing (MRI). SPET was performed with an ADAC Vertex dual-head camera. The activity ratios of striatal to cere- bellar uptake were used as a semiquantitative parameter of striatal dopamine transporter (DAT) and D2 receptor (D2R) binding. Compared with age-matched controls, patients with TBI had significantly lower striatal/cere- bellar β-CIT and IBZM binding ratios (P≤0.01). Overall, the DAT deficit was more marked than the D2R loss. CCT and MRI studies revealed varying cortical and sub- cortical lesions, with the frontal lobe being most fre- quently affected whereas the striatum appeared structur- ally normal in all but one patient. Our findings suggest that nigrostriatal dysfunction may be detected using SPET following TBI despite relative structural preserva- tion of the striatum. Further investigations of possible clinical correlates and efficacy of dopaminergic therapy in patients with TBI seem justified." @default.
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- W307112592 date "2000-01-01" @default.
- W307112592 modified "2023-09-27" @default.
- W307112592 title "Impaired dopaminergic neurotransmission in patients with traumatic brain injury: a SPET study using 123 I-β-CIT" @default.
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