Matches in SemOpenAlex for { <https://semopenalex.org/work/W30712740> ?p ?o ?g. }
- W30712740 endingPage "47" @default.
- W30712740 startingPage "939" @default.
- W30712740 abstract "Juvenile polyps are regarded as hamartomatous polyps and occur in sporadic and familial syndromic settings. There is increased risk of gastrointestinal neoplasia in patients with juvenile polyposis syndrome, but the molecular mechanisms are not known. We therefore studied 78 colorectal juvenile polyposis from 12 patients with juvenile polyps syndrome and 34 sporadic juvenile polyps for epithelial dysplasia and genetic changes associated with colorectal neoplasia. Dysplasia occurred in 31% of syndromic juvenile polyps but not in sporadic juvenile polyps (P < 0.0001). Topographic control of proliferation and expression of the cyclin-dependent kinase inhibitor p21(WAFI/CIP1) seen in native colorectal epithelium was lost in 79% of dysplastic juvenile polyps and in 8% of nondysplastic juvenile polyps (P < 0.000001). Somatic mutations in the adenomatous polyposis coli (APC) gene were demonstrated in 50% of dysplastic juvenile polyps (3 of 6) but not in any of 16 juvenile polyps without dysplasia (P = 0.01). Both sporadic and syndromic juvenile polyps had K-ras mutations (14%) and there was no relationship to dysplasia. p53 gene product overexpression identified by immunohistochemical staining occurred rarely in dysplastic juvenile polyps (2 of 24, 8%). Our results indicate that the multiple genetic alterations involved in usual colorectal neoplasia also play a role in neoplastic transformation of juvenile polyps, predominantly in juvenile polyposis syndrome." @default.
- W30712740 created "2016-06-24" @default.
- W30712740 creator A5002209179 @default.
- W30712740 creator A5025364591 @default.
- W30712740 creator A5036379332 @default.
- W30712740 creator A5041682018 @default.
- W30712740 creator A5055630196 @default.
- W30712740 creator A5076284973 @default.
- W30712740 creator A5078636533 @default.
- W30712740 creator A5079056789 @default.
- W30712740 creator A5087681575 @default.
- W30712740 creator A5088389768 @default.
- W30712740 creator A5091703176 @default.
- W30712740 date "1997-03-01" @default.
- W30712740 modified "2023-10-05" @default.
- W30712740 title "Genetic alterations and epithelial dysplasia in juvenile polyposis syndrome and sporadic juvenile polyps." @default.
- W30712740 cites W1272232200 @default.
- W30712740 cites W1487867498 @default.
- W30712740 cites W1505025572 @default.
- W30712740 cites W1540575218 @default.
- W30712740 cites W1628906992 @default.
- W30712740 cites W1663072708 @default.
- W30712740 cites W174527472 @default.
- W30712740 cites W1768562956 @default.
- W30712740 cites W1784705092 @default.
- W30712740 cites W1796421912 @default.
- W30712740 cites W1822574420 @default.
- W30712740 cites W1859231335 @default.
- W30712740 cites W1922658736 @default.
- W30712740 cites W1938145277 @default.
- W30712740 cites W1964233303 @default.
- W30712740 cites W1964612722 @default.
- W30712740 cites W1969109852 @default.
- W30712740 cites W1970097275 @default.
- W30712740 cites W1970869943 @default.
- W30712740 cites W1973800266 @default.
- W30712740 cites W1980759325 @default.
- W30712740 cites W1988649650 @default.
- W30712740 cites W1988762859 @default.
- W30712740 cites W1995257964 @default.
- W30712740 cites W1998890354 @default.
- W30712740 cites W2001258296 @default.
- W30712740 cites W2004100110 @default.
- W30712740 cites W2014469860 @default.
- W30712740 cites W2015519364 @default.
- W30712740 cites W2018348035 @default.
- W30712740 cites W2036026152 @default.
- W30712740 cites W2036912409 @default.
- W30712740 cites W2040211249 @default.
- W30712740 cites W2040876807 @default.
- W30712740 cites W2047420232 @default.
- W30712740 cites W2049628526 @default.
- W30712740 cites W2054270482 @default.
- W30712740 cites W2064711653 @default.
- W30712740 cites W2071697240 @default.
- W30712740 cites W2077445146 @default.
- W30712740 cites W2081290278 @default.
- W30712740 cites W2088098884 @default.
- W30712740 cites W2088661249 @default.
- W30712740 cites W2091723114 @default.
- W30712740 cites W2102133158 @default.
- W30712740 cites W2106212265 @default.
- W30712740 cites W2124271715 @default.
- W30712740 cites W2133243631 @default.
- W30712740 cites W2134598096 @default.
- W30712740 cites W2149219789 @default.
- W30712740 cites W2163299886 @default.
- W30712740 cites W2165149979 @default.
- W30712740 cites W2314753851 @default.
- W30712740 cites W2315576934 @default.
- W30712740 cites W2340443284 @default.
- W30712740 cites W2411199934 @default.
- W30712740 cites W2427903044 @default.
- W30712740 cites W2467700252 @default.
- W30712740 cites W4249263639 @default.
- W30712740 cites W48596264 @default.
- W30712740 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1857899" @default.
- W30712740 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9060832" @default.
- W30712740 hasPublicationYear "1997" @default.
- W30712740 type Work @default.
- W30712740 sameAs 30712740 @default.
- W30712740 citedByCount "23" @default.
- W30712740 countsByYear W307127402013 @default.
- W30712740 countsByYear W307127402014 @default.
- W30712740 countsByYear W307127402016 @default.
- W30712740 countsByYear W307127402017 @default.
- W30712740 countsByYear W307127402022 @default.
- W30712740 crossrefType "journal-article" @default.
- W30712740 hasAuthorship W30712740A5002209179 @default.
- W30712740 hasAuthorship W30712740A5025364591 @default.
- W30712740 hasAuthorship W30712740A5036379332 @default.
- W30712740 hasAuthorship W30712740A5041682018 @default.
- W30712740 hasAuthorship W30712740A5055630196 @default.
- W30712740 hasAuthorship W30712740A5076284973 @default.
- W30712740 hasAuthorship W30712740A5078636533 @default.
- W30712740 hasAuthorship W30712740A5079056789 @default.
- W30712740 hasAuthorship W30712740A5087681575 @default.
- W30712740 hasAuthorship W30712740A5088389768 @default.