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- W307131126 abstract "Acetylcholinesterase (AChE) from avian and mammalian tissues can be separated by sedimentation analysis into several molecular forms, in a manner similar to the separation of AChE forms from fish electric organs (Hall, Z., J. Neurobiol., 4, 343–361, 1973; Vigny, M. et al., FEBS Lett. 69, 277–280, 1976). The avian and mammalian heavy molecular forms (16–20 S) become insoluble in low salt conditions, while most of the enzyme remains soluble. Several lines of evidence demonstrate that this phenomenon reflects ionic interactions with polyanionic compounds, very similar to those which are involved in the low-salt aggregation of the tailed molecular forms of AChE from the electric organ (Bon, S., Cartaud, J. and Massoulie, J., Eur. J. Biochem., 85, 1–14, 1978): (a) both phenomena are ionic strength dependent; (b) they are equally abolished by acetylation of the enzyme; and (c) polyanions interact with the isolated enzymes in a similar way. We have found that the tailed forms of AChE from Electrophorus are modified by colla-genase in a characteristic manner and that the collagen-like tail is responsible for the aggregation of the Ienzyme. Exactly parallel effects can be observed with the mammalian heavy forms: their sedimentation coefficient is increased and they become low-salt soluble, while the other molecular forms remain unmodified. It seems therefore possible that the mammalian and avian heavy forms possess a collagen-like element similar to the tail of Electrophorus AChE. In agreement with this idea, the apparent Stokes radii obtained by gelfiltra-tion chromatography reveal a markedly larger asymmetry for the heavy forms than for the lighter ones. The tails could participate in the multimolecular ionic interactions which are probably involved in the attachment of AChE to the cell coats." @default.
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- W307131126 date "1979-01-01" @default.
- W307131126 modified "2023-10-17" @default.
- W307131126 title "Low Ionic Strength Aggregation and Collagenase Sensitivity of Some Acetylcholinesterase Molecular Forms from Avian and Mammalian Tissues" @default.
- W307131126 doi "https://doi.org/10.1016/s0079-6123(08)64663-4" @default.
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