Matches in SemOpenAlex for { <https://semopenalex.org/work/W3072824> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3072824 endingPage "E229" @default.
- W3072824 startingPage "E224" @default.
- W3072824 abstract "We have injected rats with [3H]aldosterone or [3H]corticosterone, plus 100-fold excess of the highly specific glucocorticoid RU 28362, with or without excess unlabeled aldosterone or corticosterone and compared type I receptor occupancy in kidney and hippocampus. Thirty minutes after subcutaneous injection [3H]aldosterone was well retained in renal papilla-inner medulla, renal cortex-outer medulla, and hippocampus; in contrast, [3H]corticosterone was well retained only in hippocampus. Competition studies for [3H]aldosterone binding sites showed corticosterone to be a poor competitor in the kidney compared with hippocampus. Time-course studies, with rats killed 10-180 min after tracer administration, showed very low uptake/retention of [3H]corticosterone by kidney; in hippocampus [3H]corticosterone retention was similar to that of [3H]aldosterone in kidney, and retention of [3H]aldosterone by hippocampus was much more prolonged than of either tracer in any other tissue. Studies in 10-day-old rats, with very low levels of corticosteroid binding globulin (CBG), showed a high degree of aldosterone selectivity in both zones of the kidney, whereas [3H]aldosterone and [3H]corticosterone were equivalently bound in hippocampus. We interpret these data as evidence for a mechanism unrelated to extravascular CBG conferring mineralocorticoid specificity on renal type I receptors and propose two models derived from our findings consistent with such differential selectivity." @default.
- W3072824 created "2016-06-24" @default.
- W3072824 creator A5019746134 @default.
- W3072824 creator A5041530254 @default.
- W3072824 date "1987-02-01" @default.
- W3072824 modified "2023-10-14" @default.
- W3072824 title "Mineralocorticoid specificity of renal type I receptors: in vivo binding studies" @default.
- W3072824 cites W1975574477 @default.
- W3072824 cites W1976840810 @default.
- W3072824 cites W1997274927 @default.
- W3072824 cites W1999445328 @default.
- W3072824 cites W2004376767 @default.
- W3072824 cites W2029179291 @default.
- W3072824 cites W2031048120 @default.
- W3072824 cites W2031752348 @default.
- W3072824 cites W2051782827 @default.
- W3072824 cites W2055493078 @default.
- W3072824 cites W2060944643 @default.
- W3072824 cites W2063014237 @default.
- W3072824 cites W2068921569 @default.
- W3072824 cites W2070061971 @default.
- W3072824 cites W2078649311 @default.
- W3072824 cites W2086216109 @default.
- W3072824 cites W2090780120 @default.
- W3072824 cites W2156614560 @default.
- W3072824 doi "https://doi.org/10.1152/ajpendo.1987.252.2.e224" @default.
- W3072824 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3030124" @default.
- W3072824 hasPublicationYear "1987" @default.
- W3072824 type Work @default.
- W3072824 sameAs 3072824 @default.
- W3072824 citedByCount "20" @default.
- W3072824 countsByYear W30728242013 @default.
- W3072824 countsByYear W30728242014 @default.
- W3072824 countsByYear W30728242021 @default.
- W3072824 crossrefType "journal-article" @default.
- W3072824 hasAuthorship W3072824A5019746134 @default.
- W3072824 hasAuthorship W3072824A5041530254 @default.
- W3072824 hasConcept C126322002 @default.
- W3072824 hasConcept C134018914 @default.
- W3072824 hasConcept C170493617 @default.
- W3072824 hasConcept C185592680 @default.
- W3072824 hasConcept C189135053 @default.
- W3072824 hasConcept C2776069600 @default.
- W3072824 hasConcept C2778525890 @default.
- W3072824 hasConcept C2780091579 @default.
- W3072824 hasConcept C2780352252 @default.
- W3072824 hasConcept C2780841215 @default.
- W3072824 hasConcept C2781161787 @default.
- W3072824 hasConcept C59493245 @default.
- W3072824 hasConcept C71315377 @default.
- W3072824 hasConcept C71924100 @default.
- W3072824 hasConcept C86803240 @default.
- W3072824 hasConceptScore W3072824C126322002 @default.
- W3072824 hasConceptScore W3072824C134018914 @default.
- W3072824 hasConceptScore W3072824C170493617 @default.
- W3072824 hasConceptScore W3072824C185592680 @default.
- W3072824 hasConceptScore W3072824C189135053 @default.
- W3072824 hasConceptScore W3072824C2776069600 @default.
- W3072824 hasConceptScore W3072824C2778525890 @default.
- W3072824 hasConceptScore W3072824C2780091579 @default.
- W3072824 hasConceptScore W3072824C2780352252 @default.
- W3072824 hasConceptScore W3072824C2780841215 @default.
- W3072824 hasConceptScore W3072824C2781161787 @default.
- W3072824 hasConceptScore W3072824C59493245 @default.
- W3072824 hasConceptScore W3072824C71315377 @default.
- W3072824 hasConceptScore W3072824C71924100 @default.
- W3072824 hasConceptScore W3072824C86803240 @default.
- W3072824 hasIssue "2" @default.
- W3072824 hasLocation W30728241 @default.
- W3072824 hasLocation W30728242 @default.
- W3072824 hasOpenAccess W3072824 @default.
- W3072824 hasPrimaryLocation W30728241 @default.
- W3072824 hasRelatedWork W1903778294 @default.
- W3072824 hasRelatedWork W1977153383 @default.
- W3072824 hasRelatedWork W2023418293 @default.
- W3072824 hasRelatedWork W2024166813 @default.
- W3072824 hasRelatedWork W2037408526 @default.
- W3072824 hasRelatedWork W2067578907 @default.
- W3072824 hasRelatedWork W2092107317 @default.
- W3072824 hasRelatedWork W2156866593 @default.
- W3072824 hasRelatedWork W2276893008 @default.
- W3072824 hasRelatedWork W4232773839 @default.
- W3072824 hasVolume "252" @default.
- W3072824 isParatext "false" @default.
- W3072824 isRetracted "false" @default.
- W3072824 magId "3072824" @default.
- W3072824 workType "article" @default.