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- W3073180599 abstract "The healing process of diabetic wounds is typically disordered and prolonged and requires both angiogenesis and epithelialization. Disruptions of the endogenous electric fields (EFs) may lead to disordered cell migration. Electrical stimulation (ES) that mimics endogenous EFs is a promising method in treating diabetic wounds; however, a microenvironment that facilitates cell migration and a convenient means that can be used to apply ES are also required. Chitosan-Vaseline® gauze (CVG) has been identified to facilitate wound healing; it also promotes moisture retention and immune regulation and has antibacterial activity. For this study, we created a wound dressing using CVG together with a flexible ES device and further evaluated its potential as a treatment for diabetic wounds. We found that high voltage monophasic pulsed current (HVMPC) promoted healing of diabetic wounds in vivo. In studies carried out in vitro, we found that HVMPC promoted the proliferation and migration of human umbilical vein endothelial cells (HUVECs) by activating PI3K/Akt and ERK1/2 signaling. Overall, we determined that the flexible ES-chitosan dressing may promoted healing of diabetic wounds by accelerating angiogenesis, enhancing epithelialization, and inhibiting scar formation. These findings provide support for the ongoing development of this multidisciplinary product for the care and treatment of diabetic wounds." @default.
- W3073180599 created "2020-08-24" @default.
- W3073180599 creator A5010642871 @default.
- W3073180599 creator A5024745399 @default.
- W3073180599 creator A5031991326 @default.
- W3073180599 creator A5036008969 @default.
- W3073180599 creator A5049085954 @default.
- W3073180599 creator A5068438374 @default.
- W3073180599 creator A5075199481 @default.
- W3073180599 creator A5082857859 @default.
- W3073180599 creator A5086657866 @default.
- W3073180599 date "2021-01-01" @default.
- W3073180599 modified "2023-10-05" @default.
- W3073180599 title "Flexible electrical stimulation device with Chitosan-Vaseline® dressing accelerates wound healing in diabetes" @default.
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