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• W3073804858 abstract "The safety and efficacy of anti-diabetic drugs are critical for maximizing the beneficial impacts of well-controlled blood glucose on the prognosis of individuals with COVID-19 and pre-existing type 2 diabetes (T2D). Metformin is the most commonly prescribed first-line medication for T2D, but its impact on the outcomes of individuals with COVID-19 and T2D remains to be clarified. Our current retrospective study in a cohort of 1,213 hospitalized individuals with COVID-19 and pre-existing T2D indicated that metformin use was significantly associated with a higher incidence of acidosis, particularly in cases with severe COVID-19, but not with 28-day COVID-19-related mortality. Furthermore, metformin use was significantly associated with reduced heart failure and inflammation. Our findings provide clinical evidence in support of continuing metformin treatment in individuals with COVID-19 and pre-existing T2D, but acidosis and kidney function should be carefully monitored in individuals with severe COVID-19." @default.
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• W3073804858 date "2020-10-01" @default.
• W3073804858 modified "2023-10-11" @default.
• W3073804858 title "Metformin Is Associated with Higher Incidence of Acidosis, but Not Mortality, in Individuals with COVID-19 and Pre-existing Type 2 Diabetes" @default.
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• W3073804858 doi "https://doi.org/10.1016/j.cmet.2020.08.013" @default.
• W3073804858 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7439986" @default.
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• W3073804858 hasPublicationYear "2020" @default.
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