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• W3075100325 abstract "Abstract Background The Sri Lankan traditional betel quid (TBQ) which had been extensively used in the country before its colonization is claimed to have antiperiodontopathic effects in the Sri Lankan folklore. However, there is no reported scientific evidence to support the claimed antiperiodontopathic effects mediated by this TBQ. The present study was carried out to investigate the protective effect of the Sri Lankan TBQ in the pathogenesis of periodontitis. Methods We investigate the ethyl acetate extract of the Sri Lankan TBQ for its antibacterial effects against the keystone periodontopathic bacterium, P. gingivalis and also its antioxidant potential, which is important to protect the periodontium from oxidative stress. Further, its safety was analyzed using the cytokinesis block micronucleus assay on human peripheral blood lymphocytes (PBLs). Results Ethyl acetate extract of this TBQ inhibited the growth of P. gingivalis with a minimum bactericidal concentration (MBC) of 125 μg/ml. It was found to be a rich source of polyphenols and displayed considerable DPPH and ABTS radical scavenging activities and a strong ferric reducing antioxidant power. This extract could protect the cultured human gingival fibroblasts from H 2 O 2 induced oxidative stress. In addition, this TBQ extract was not genotoxic to human PBLs even at a concentration of 2.5 mg/ml. Moreover, it exhibited protective effects against bleomycin induced genotoxicity in PBLs. Conclusion Ethyl acetate extract of the Sri Lankan TBQ is a source of natural antibacterial compounds against P. gingivalis . It is also a source of natural antioxidants which can protect human gingival fibroblasts from H 2 O 2 induced oxidative stress. These properties of the TBQ may have contributed to its claimed antiperiodontopathic effects. Besides, it was found to be relatively non-toxic to human cells. Thus this TBQ extract has a huge potential to be developed as a novel adjunctive therapeutic lead against periodontitis." @default.
• W3075100325 created "2020-08-24" @default.
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• W3075100325 date "2020-08-20" @default.
• W3075100325 modified "2023-10-16" @default.
• W3075100325 title "The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study" @default.
• W3075100325 cites W1520881062 @default.
• W3075100325 cites W1526856981 @default.
• W3075100325 cites W1552020203 @default.
• W3075100325 cites W1558754314 @default.
• W3075100325 cites W1571823809 @default.
• W3075100325 cites W1593195558 @default.
• W3075100325 cites W1914622032 @default.
• W3075100325 cites W1964416796 @default.
• W3075100325 cites W1966734873 @default.
• W3075100325 cites W1972505298 @default.
• W3075100325 cites W1977163370 @default.
• W3075100325 cites W1978348233 @default.
• W3075100325 cites W1980073992 @default.
• W3075100325 cites W1983515750 @default.
• W3075100325 cites W1985573340 @default.
• W3075100325 cites W1989796277 @default.
• W3075100325 cites W1990064402 @default.
• W3075100325 cites W1991531399 @default.
• W3075100325 cites W1992958889 @default.
• W3075100325 cites W1994893732 @default.
• W3075100325 cites W1995852654 @default.
• W3075100325 cites W1998682061 @default.
• W3075100325 cites W2000749448 @default.
• W3075100325 cites W2002885186 @default.
• W3075100325 cites W2009149233 @default.
• W3075100325 cites W2009355903 @default.
• W3075100325 cites W2009367250 @default.
• W3075100325 cites W2012991711 @default.
• W3075100325 cites W2015123130 @default.
• W3075100325 cites W2023536393 @default.
• W3075100325 cites W2023937863 @default.
• W3075100325 cites W2043248182 @default.
• W3075100325 cites W2048445337 @default.
• W3075100325 cites W2052093507 @default.
• W3075100325 cites W2052124073 @default.
• W3075100325 cites W2061948662 @default.
• W3075100325 cites W2065993095 @default.
• W3075100325 cites W2067463086 @default.
• W3075100325 cites W2074167075 @default.
• W3075100325 cites W2083574453 @default.
• W3075100325 cites W2087192539 @default.
• W3075100325 cites W2097056441 @default.
• W3075100325 cites W2102483611 @default.
• W3075100325 cites W2112784018 @default.
• W3075100325 cites W2114004260 @default.
• W3075100325 cites W2139579296 @default.
• W3075100325 cites W2141206398 @default.
• W3075100325 cites W2165292984 @default.
• W3075100325 cites W2274566726 @default.
• W3075100325 cites W2320560026 @default.
• W3075100325 cites W2337245410 @default.
• W3075100325 cites W2341769195 @default.
• W3075100325 cites W2343376592 @default.
• W3075100325 cites W2467995164 @default.
• W3075100325 cites W2469832905 @default.
• W3075100325 cites W2494368998 @default.
• W3075100325 cites W2554694070 @default.
• W3075100325 cites W2568232680 @default.
• W3075100325 cites W2597775634 @default.
• W3075100325 cites W2606827426 @default.
• W3075100325 cites W2617203235 @default.
• W3075100325 cites W2740883201 @default.
• W3075100325 cites W2765604736 @default.
• W3075100325 cites W2766925184 @default.
• W3075100325 cites W2767392813 @default.
• W3075100325 cites W2771871673 @default.
• W3075100325 cites W2795919438 @default.
• W3075100325 cites W2810247650 @default.
• W3075100325 cites W2894524330 @default.
• W3075100325 cites W2902069880 @default.
• W3075100325 cites W2909306880 @default.
• W3075100325 cites W2952664434 @default.
• W3075100325 cites W2964310597 @default.
• W3075100325 cites W4210956735 @default.
• W3075100325 doi "https://doi.org/10.1186/s12906-020-03048-6" @default.
• W3075100325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7439561" @default.
• W3075100325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32819379" @default.
• W3075100325 hasPublicationYear "2020" @default.
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