Matches in SemOpenAlex for { <https://semopenalex.org/work/W3075587083> ?p ?o ?g. }
- W3075587083 endingPage "46" @default.
- W3075587083 startingPage "40" @default.
- W3075587083 abstract "Hypertensive disorders of pregnancy (HDP) represent a major cause of maternal and neonatal morbidity and mortality. Studies conducted over the last decade have improved our understanding of the potential mechanisms underlying HDP pathogenesis. The first step in HDP is reduced uteroplacental perfusion as a result of abnormal extravillous trophoblast invasion of spiral arterioles. Subsequent placental ischemia leads to maternal vascular endothelial dysfunction that may be caused by an imbalance between pro- and anti-angiogenic factors, enhanced formation of vasocontractile factors such as endothelin and thromboxane, increased vascular sensitivity to angiotensin II, and/or decreased formation of vasodilators such as nitric oxide (NO) and prostaglandin I2. NO is one of the major mediators from the endothelium, and its production is modified by endogenous NO synthase inhibitors such as asymmetric dimethylarginine (ADMA). ADMA levels are generally higher in patients with cardiovascular and metabolic diseases and widely recognized as a prognostic marker for major cardiovascular events and mortality. Recent studies have found ADMA levels to be higher in patients with preeclampsia. In addition, multiple studies indicate that elevated ADMA in early stages of pregnancy might predict the development of preeclampsia. Finally, ADMA has been found to be associated with uterine artery flow disturbance. Collectively, these findings strongly suggest that elevated ADMA-mediated endothelial dysfunction could be a causative factor for HDP. In this review, we discuss the biology of ADMA, with a particular focus on its potential role in HDP." @default.
- W3075587083 created "2020-08-24" @default.
- W3075587083 creator A5009635875 @default.
- W3075587083 creator A5042961127 @default.
- W3075587083 creator A5064701002 @default.
- W3075587083 creator A5074810793 @default.
- W3075587083 creator A5076815130 @default.
- W3075587083 date "2020-11-30" @default.
- W3075587083 modified "2023-10-16" @default.
- W3075587083 title "Pathophysiological roles of ADMA-mediated endothelial injury in hypertensive disorders of pregnancy" @default.
- W3075587083 cites W1507244839 @default.
- W3075587083 cites W1918788146 @default.
- W3075587083 cites W1963934554 @default.
- W3075587083 cites W1964249453 @default.
- W3075587083 cites W1970798352 @default.
- W3075587083 cites W1977312076 @default.
- W3075587083 cites W1981206324 @default.
- W3075587083 cites W1983186128 @default.
- W3075587083 cites W1992049725 @default.
- W3075587083 cites W1992101378 @default.
- W3075587083 cites W1994223673 @default.
- W3075587083 cites W2000881220 @default.
- W3075587083 cites W2003198833 @default.
- W3075587083 cites W2010402015 @default.
- W3075587083 cites W2012969794 @default.
- W3075587083 cites W2017543118 @default.
- W3075587083 cites W2020461195 @default.
- W3075587083 cites W2023492147 @default.
- W3075587083 cites W2023534221 @default.
- W3075587083 cites W2028036742 @default.
- W3075587083 cites W2028491490 @default.
- W3075587083 cites W2040643466 @default.
- W3075587083 cites W2041052090 @default.
- W3075587083 cites W2043183828 @default.
- W3075587083 cites W2043957477 @default.
- W3075587083 cites W2058385357 @default.
- W3075587083 cites W2063289338 @default.
- W3075587083 cites W2065374983 @default.
- W3075587083 cites W2066636722 @default.
- W3075587083 cites W2067251916 @default.
- W3075587083 cites W2070693585 @default.
- W3075587083 cites W2074355812 @default.
- W3075587083 cites W2076680300 @default.
- W3075587083 cites W2079670630 @default.
- W3075587083 cites W2083164971 @default.
- W3075587083 cites W2083518460 @default.
- W3075587083 cites W2085625674 @default.
- W3075587083 cites W2098143325 @default.
- W3075587083 cites W2098154479 @default.
- W3075587083 cites W2105082749 @default.
- W3075587083 cites W2106478344 @default.
- W3075587083 cites W2115421882 @default.
- W3075587083 cites W2115875498 @default.
- W3075587083 cites W2117156673 @default.
- W3075587083 cites W2119861336 @default.
- W3075587083 cites W2120210536 @default.
- W3075587083 cites W2123706039 @default.
- W3075587083 cites W2124728251 @default.
- W3075587083 cites W2127398792 @default.
- W3075587083 cites W2129050578 @default.
- W3075587083 cites W2130469526 @default.
- W3075587083 cites W2133371348 @default.
- W3075587083 cites W2134310604 @default.
- W3075587083 cites W2136106925 @default.
- W3075587083 cites W2137708021 @default.
- W3075587083 cites W2143541397 @default.
- W3075587083 cites W2145183598 @default.
- W3075587083 cites W2150119335 @default.
- W3075587083 cites W2151554519 @default.
- W3075587083 cites W2153110646 @default.
- W3075587083 cites W2154388708 @default.
- W3075587083 cites W2159442474 @default.
- W3075587083 cites W2166912566 @default.
- W3075587083 cites W2166937516 @default.
- W3075587083 cites W2169877701 @default.
- W3075587083 cites W2170084770 @default.
- W3075587083 cites W2173192280 @default.
- W3075587083 cites W2274495764 @default.
- W3075587083 cites W2342639549 @default.
- W3075587083 cites W2419565081 @default.
- W3075587083 cites W2758998564 @default.
- W3075587083 cites W2793594342 @default.
- W3075587083 cites W2797873868 @default.
- W3075587083 cites W2807030010 @default.
- W3075587083 cites W2883207089 @default.
- W3075587083 cites W2914787585 @default.
- W3075587083 doi "https://doi.org/10.14390/jsshp.hrp2019-013" @default.
- W3075587083 hasPublicationYear "2020" @default.
- W3075587083 type Work @default.
- W3075587083 sameAs 3075587083 @default.
- W3075587083 citedByCount "1" @default.
- W3075587083 countsByYear W30755870832023 @default.
- W3075587083 crossrefType "journal-article" @default.
- W3075587083 hasAuthorship W3075587083A5009635875 @default.
- W3075587083 hasAuthorship W3075587083A5042961127 @default.
- W3075587083 hasAuthorship W3075587083A5064701002 @default.
- W3075587083 hasAuthorship W3075587083A5074810793 @default.
- W3075587083 hasAuthorship W3075587083A5076815130 @default.