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- W3075887621 abstract "Dr. Mark Mattson has had a highly productive and impactful tenure as a neuroscientist at the Intramural Research Program of the National Institute on Aging. He has made notable contributions to understanding the mechanisms by which energetic stress, imparted by behaviors such as physical activity and periods of fasting, promotes rejuvenation and resilience within brain regions critical for learning and memory. In honor of Dr. Mattson's work, this manuscript will highlight the fascinating mechanisms by which endurance exercise training conveys beneficial effects upon the structure and function of the nervous system; that is, by mediating the synthesis and secretion of factors that directly support brain homeostasis, including brain-derived neurotrophic factor, FNDC5/irisin, ketone bodies, growth factors, cathepsin B, serotonin, and 4-hydroxynonenal. The molecular and cellular effects of these factors are discussed herein. In the face of population aging and an overwhelming surge in the prevalence of Alzheimer's disease and related disorders, Dr. Mattson's work as a champion and role model for physically active lifestyles is more important than ever." @default.
- W3075887621 created "2020-08-24" @default.
- W3075887621 creator A5011943893 @default.
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- W3075887621 date "2020-12-01" @default.
- W3075887621 modified "2023-10-15" @default.
- W3075887621 title "Harnessing the effects of endurance exercise to optimize cognitive health: Fundamental insights from Dr. Mark P. Mattson" @default.
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- W3075887621 doi "https://doi.org/10.1016/j.arr.2020.101147" @default.
- W3075887621 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7710559" @default.