FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W30759828> ?p ?o ?g. }

• W30759828 endingPage "406" @default.
• W30759828 startingPage "393" @default.
• W30759828 abstract "Currently, two reconstructed human skin models, EpiDerm and EPISKIN are being evaluated in an ECVAM skin irritation validation study. A common skin irritation protocol has been developed, differing only in minor technical details for the two models. A small-scale study, applying this common skin irritation protocol to the SkinEthic reconstructed human epidermis (RHE), was performed at ZEBET at the BfR, Berlin, Germany, to consider whether this protocol could be successfully transferred to another epidermal model. Twenty substances from Phase III of the ECVAM prevalidation study on skin irritation were tested with the SkinEthic RHE. After minor, model-specific adaptations for the SkinEthic RHE, almost identical results to those obtained with the EpiDerm and EPISKIN models were achieved. The overall accuracy of the method was more than 80%, indicating a reliable prediction of the skin irritation potential of the tested chemicals when compared to in vivo rabbit data. As a next step, inter laboratory reproducibility was assessed in a study conducted between ZEBET and the Department of Experimental Toxicology, Schering AG, Berlin, Germany. Six coded substances were tested in both laboratories, with three different batches of the SkinEthic model. The assay results showed good reproducibility and correct predictions of the skin irritation potential for all six test chemicals. The results obtained with the SkinEthic RHE and the common protocol were reproducible in both phases, and the overall outcome is very similar to that of earlier studies with the EPISKIN and EpiDerm models. Therefore, the SkinEthic skin irritation assay test protocol can now be evaluated in a formal catch-up validation study." @default.
• W30759828 created "2016-06-24" @default.
• W30759828 creator A5006154101 @default.
• W30759828 creator A5023790719 @default.
• W30759828 creator A5034024376 @default.
• W30759828 creator A5039256213 @default.
• W30759828 creator A5042979601 @default.
• W30759828 creator A5054915346 @default.
• W30759828 creator A5058274458 @default.
• W30759828 creator A5066760343 @default.
• W30759828 creator A5072645031 @default.
• W30759828 creator A5079990086 @default.
• W30759828 creator A5085689791 @default.
• W30759828 date "2006-08-01" @default.
• W30759828 modified "2023-09-23" @default.
• W30759828 title "Assessment of the Skin Irritation Potential of Chemicals by Using the SkinEthic Reconstructed Human Epidermal Model and the Common Skin Irritation Protocol Evaluated in the ECVAM Skin Irritation Validation Study" @default.
• W30759828 cites W160951082 @default.
• W30759828 cites W1969723122 @default.
• W30759828 cites W1971537733 @default.
• W30759828 cites W1990896467 @default.
• W30759828 cites W2024409040 @default.
• W30759828 cites W2036193434 @default.
• W30759828 cites W2044560197 @default.
• W30759828 cites W2065027674 @default.
• W30759828 cites W2069125289 @default.
• W30759828 cites W2114918609 @default.
• W30759828 cites W2183702510 @default.
• W30759828 cites W2783128377 @default.
• W30759828 cites W4236592407 @default.
• W30759828 cites W4239144043 @default.
• W30759828 doi "https://doi.org/10.1177/026119290603400407" @default.
• W30759828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16945007" @default.
• W30759828 hasPublicationYear "2006" @default.
• W30759828 type Work @default.
• W30759828 sameAs 30759828 @default.
• W30759828 citedByCount "42" @default.
• W30759828 countsByYear W307598282012 @default.
• W30759828 countsByYear W307598282013 @default.
• W30759828 countsByYear W307598282014 @default.
• W30759828 countsByYear W307598282016 @default.
• W30759828 countsByYear W307598282017 @default.
• W30759828 countsByYear W307598282018 @default.
• W30759828 countsByYear W307598282019 @default.
• W30759828 countsByYear W307598282020 @default.
• W30759828 countsByYear W307598282021 @default.
• W30759828 countsByYear W307598282022 @default.
• W30759828 countsByYear W307598282023 @default.
• W30759828 crossrefType "journal-article" @default.
• W30759828 hasAuthorship W30759828A5006154101 @default.
• W30759828 hasAuthorship W30759828A5023790719 @default.
• W30759828 hasAuthorship W30759828A5034024376 @default.
• W30759828 hasAuthorship W30759828A5039256213 @default.
• W30759828 hasAuthorship W30759828A5042979601 @default.
• W30759828 hasAuthorship W30759828A5054915346 @default.
• W30759828 hasAuthorship W30759828A5058274458 @default.
• W30759828 hasAuthorship W30759828A5066760343 @default.
• W30759828 hasAuthorship W30759828A5072645031 @default.
• W30759828 hasAuthorship W30759828A5079990086 @default.
• W30759828 hasAuthorship W30759828A5085689791 @default.
• W30759828 hasBestOaLocation W307598281 @default.
• W30759828 hasConcept C142724271 @default.
• W30759828 hasConcept C16005928 @default.
• W30759828 hasConcept C185592680 @default.
• W30759828 hasConcept C203014093 @default.
• W30759828 hasConcept C204787440 @default.
• W30759828 hasConcept C2777063393 @default.
• W30759828 hasConcept C2777459323 @default.
• W30759828 hasConcept C2780385302 @default.
• W30759828 hasConcept C3019129585 @default.
• W30759828 hasConcept C43617362 @default.
• W30759828 hasConcept C54355233 @default.
• W30759828 hasConcept C71924100 @default.
• W30759828 hasConcept C86803240 @default.
• W30759828 hasConcept C9893847 @default.
• W30759828 hasConceptScore W30759828C142724271 @default.
• W30759828 hasConceptScore W30759828C16005928 @default.
• W30759828 hasConceptScore W30759828C185592680 @default.
• W30759828 hasConceptScore W30759828C203014093 @default.
• W30759828 hasConceptScore W30759828C204787440 @default.
• W30759828 hasConceptScore W30759828C2777063393 @default.
• W30759828 hasConceptScore W30759828C2777459323 @default.
• W30759828 hasConceptScore W30759828C2780385302 @default.
• W30759828 hasConceptScore W30759828C3019129585 @default.
• W30759828 hasConceptScore W30759828C43617362 @default.
• W30759828 hasConceptScore W30759828C54355233 @default.
• W30759828 hasConceptScore W30759828C71924100 @default.
• W30759828 hasConceptScore W30759828C86803240 @default.
• W30759828 hasConceptScore W30759828C9893847 @default.
• W30759828 hasIssue "4" @default.
• W30759828 hasLocation W307598281 @default.
• W30759828 hasLocation W307598282 @default.
• W30759828 hasOpenAccess W30759828 @default.
• W30759828 hasPrimaryLocation W307598281 @default.
• W30759828 hasRelatedWork W1487275967 @default.
• W30759828 hasRelatedWork W1842168445 @default.
• W30759828 hasRelatedWork W1966788665 @default.
• W30759828 hasRelatedWork W1971161204 @default.
• W30759828 hasRelatedWork W2049701255 @default.

• next