FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3076322419> ?p ?o ?g. }

• W3076322419 endingPage "56" @default.
• W3076322419 startingPage "50" @default.
• W3076322419 abstract "Abstract Reduced expression of the Indy (I’m Not Dead Yet) gene extends life span in Caenorhabditis elegans and Drosophila melanogaster and improves the metabolic heath of Mus musculus through inducing a physiological status akin to dietary restriction (DR). Although the function of Indy in aging and hepatic metabolism has been extensively studied, its role in the mouse nervous system remains unclear. Here, we explore the effect of mammalian Indy (mIndy, SLC13A5) gene deletion on murine cognitive function. Similar to what is seen in DR animals, systemic deletion of the mIndy gene (mIndy knockout [KO]) significantly improves memory performance and motor coordination of mice. Both DR and mIndy KO mice act normally in other behavioral tasks, including emotional, social, and food-seeking behaviors. Moreover, we find that tissue-specific deletion of mIndy in the nervous system is sufficient to improve memory performance, while liver-specific deletion has no effect on memory, and results in tests of motor coordination show no changes in either mutant. Mice with systemic or nervous system deletion of mIndy also exhibit increased hippocampal neurogenesis and dendritic spine formation in dentate granule cells; these changes are well-documented contributors to enhanced memory performance. Together, our studies demonstrate a critical role for brain-derived mIndy expression in the regulation of memory function in animals." @default.
• W3076322419 created "2020-08-24" @default.
• W3076322419 creator A5009174406 @default.
• W3076322419 creator A5022510305 @default.
• W3076322419 creator A5023165286 @default.
• W3076322419 creator A5040835437 @default.
• W3076322419 creator A5071843228 @default.
• W3076322419 creator A5072272159 @default.
• W3076322419 date "2020-08-18" @default.
• W3076322419 modified "2023-10-16" @default.
• W3076322419 title "Nervous System Deletion of <i>Mammalian INDY</i> in Mice Mimics Dietary Restriction-Induced Memory Enhancement" @default.
• W3076322419 cites W1493226253 @default.
• W3076322419 cites W1763255738 @default.
• W3076322419 cites W1968151995 @default.
• W3076322419 cites W1987738803 @default.
• W3076322419 cites W1990276200 @default.
• W3076322419 cites W1991109777 @default.
• W3076322419 cites W1991386832 @default.
• W3076322419 cites W2015550447 @default.
• W3076322419 cites W2028593623 @default.
• W3076322419 cites W2034661709 @default.
• W3076322419 cites W2049265152 @default.
• W3076322419 cites W2050196364 @default.
• W3076322419 cites W2054110063 @default.
• W3076322419 cites W2060814375 @default.
• W3076322419 cites W2061169091 @default.
• W3076322419 cites W2065261177 @default.
• W3076322419 cites W2067273260 @default.
• W3076322419 cites W2078740239 @default.
• W3076322419 cites W2094399669 @default.
• W3076322419 cites W2117506912 @default.
• W3076322419 cites W2119590323 @default.
• W3076322419 cites W2122456662 @default.
• W3076322419 cites W2124483853 @default.
• W3076322419 cites W2133556218 @default.
• W3076322419 cites W2143912485 @default.
• W3076322419 cites W2146229756 @default.
• W3076322419 cites W2151162839 @default.
• W3076322419 cites W2161970758 @default.
• W3076322419 cites W2180590999 @default.
• W3076322419 cites W2186613797 @default.
• W3076322419 cites W2334796912 @default.
• W3076322419 cites W2411915694 @default.
• W3076322419 cites W2531271987 @default.
• W3076322419 cites W2555579193 @default.
• W3076322419 cites W2577597748 @default.
• W3076322419 cites W2581380146 @default.
• W3076322419 cites W2593237849 @default.
• W3076322419 cites W2610621727 @default.
• W3076322419 cites W2739242883 @default.
• W3076322419 cites W2750582921 @default.
• W3076322419 cites W2750998547 @default.
• W3076322419 cites W2783535973 @default.
• W3076322419 cites W2789926450 @default.
• W3076322419 cites W2921047793 @default.
• W3076322419 doi "https://doi.org/10.1093/gerona/glaa203" @default.
• W3076322419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32808644" @default.
• W3076322419 hasPublicationYear "2020" @default.
• W3076322419 type Work @default.
• W3076322419 sameAs 3076322419 @default.
• W3076322419 citedByCount "13" @default.
• W3076322419 countsByYear W30763224192021 @default.
• W3076322419 countsByYear W30763224192022 @default.
• W3076322419 countsByYear W30763224192023 @default.
• W3076322419 crossrefType "journal-article" @default.
• W3076322419 hasAuthorship W3076322419A5009174406 @default.
• W3076322419 hasAuthorship W3076322419A5022510305 @default.
• W3076322419 hasAuthorship W3076322419A5023165286 @default.
• W3076322419 hasAuthorship W3076322419A5040835437 @default.
• W3076322419 hasAuthorship W3076322419A5071843228 @default.
• W3076322419 hasAuthorship W3076322419A5072272159 @default.
• W3076322419 hasConcept C104317684 @default.
• W3076322419 hasConcept C148762608 @default.
• W3076322419 hasConcept C169760540 @default.
• W3076322419 hasConcept C182704531 @default.
• W3076322419 hasConcept C2776464000 @default.
• W3076322419 hasConcept C2778944004 @default.
• W3076322419 hasConcept C2780104201 @default.
• W3076322419 hasConcept C2781161787 @default.
• W3076322419 hasConcept C4746552 @default.
• W3076322419 hasConcept C529278444 @default.
• W3076322419 hasConcept C54355233 @default.
• W3076322419 hasConcept C545706735 @default.
• W3076322419 hasConcept C86803240 @default.
• W3076322419 hasConcept C95444343 @default.
• W3076322419 hasConceptScore W3076322419C104317684 @default.
• W3076322419 hasConceptScore W3076322419C148762608 @default.
• W3076322419 hasConceptScore W3076322419C169760540 @default.
• W3076322419 hasConceptScore W3076322419C182704531 @default.
• W3076322419 hasConceptScore W3076322419C2776464000 @default.
• W3076322419 hasConceptScore W3076322419C2778944004 @default.
• W3076322419 hasConceptScore W3076322419C2780104201 @default.
• W3076322419 hasConceptScore W3076322419C2781161787 @default.
• W3076322419 hasConceptScore W3076322419C4746552 @default.
• W3076322419 hasConceptScore W3076322419C529278444 @default.
• W3076322419 hasConceptScore W3076322419C54355233 @default.
• W3076322419 hasConceptScore W3076322419C545706735 @default.
• W3076322419 hasConceptScore W3076322419C86803240 @default.

• next