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- W3077714497 abstract "Abstract The genomes of RNA viruses contain regulatory elements of varying complexity. Many plus-strand RNA viruses employ largescale intra-genomic RNA-RNA interactions as a means to control viral processes. Here, we describe an elaborate RNA structure formed by multiple distant regions in a tombusvirus genome that activates transcription of a viral subgenomic mRNA. The initial step in assembly of this intramolecular RNA complex involves the folding of a large viral RNA domain, which generates a discontinuous binding pocket. Next, a distally-located protracted stem-loop RNA structure docks, via base-pairing, into the binding site and acts as a linchpin that stabilizes the RNA complex and activates transcription. A multi-step RNA folding pathway is proposed in which rate-limiting steps contribute to a delay in transcription of the capsid protein-encoding viral subgenomic mRNA. This study provides an exceptional example of the complexity of genome-scale viral regulation and offers new insights into the assembly schemes utilized by large intra-genomic RNA structures." @default.
- W3077714497 created "2020-08-24" @default.
- W3077714497 creator A5066589795 @default.
- W3077714497 creator A5068654040 @default.
- W3077714497 date "2020-08-12" @default.
- W3077714497 modified "2023-10-14" @default.
- W3077714497 title "Activation of viral transcription by stepwise largescale folding of an RNA virus genome" @default.
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- W3077714497 doi "https://doi.org/10.1093/nar/gkaa675" @default.
- W3077714497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7498350" @default.
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