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- W3078045561 abstract "Significance Vertebrate retinal ganglion cells (RGCs) transmit all visual signals from the eye to the brain, are the pathogenic target in glaucoma, and require the Atoh7 competence factor to develop from multipotent progenitors. Atoh7 transcription is controlled by dual cis regulatory elements, including a remote shadow enhancer (SE). In humans, loss of the SE causes NCRNA disease, with congenital blindness due to optic nerve aplasia. We generated a mouse Atoh7 SE deletion model and analyzed its effects on transcription, retinal histology, and chromatin architecture. The mutant mice express 80% less Atoh7 mRNA but retain optic nerves, unlike NCRNA patients. By systematically varying dosage in a genotypic series, we show how the dual enhancers maintain robust plasticity during RGC genesis." @default.
- W3078045561 created "2020-08-24" @default.
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- W3078045561 date "2020-08-17" @default.
- W3078045561 modified "2023-10-14" @default.
- W3078045561 title "The <i>Atoh7</i> remote enhancer provides transcriptional robustness during retinal ganglion cell development" @default.
- W3078045561 cites W1531821806 @default.
- W3078045561 cites W1536035226 @default.
- W3078045561 cites W1545529134 @default.
- W3078045561 cites W1895998181 @default.
- W3078045561 cites W1960721561 @default.
- W3078045561 cites W1969032559 @default.
- W3078045561 cites W1969698545 @default.
- W3078045561 cites W1972013835 @default.
- W3078045561 cites W1979440192 @default.
- W3078045561 cites W1979780441 @default.
- W3078045561 cites W1981101983 @default.
- W3078045561 cites W1982237034 @default.
- W3078045561 cites W1982328581 @default.
- W3078045561 cites W1986449079 @default.
- W3078045561 cites W1988517952 @default.
- W3078045561 cites W1989972710 @default.
- W3078045561 cites W1990433739 @default.
- W3078045561 cites W1991954192 @default.
- W3078045561 cites W1994750743 @default.
- W3078045561 cites W1998963247 @default.
- W3078045561 cites W1999254348 @default.
- W3078045561 cites W2006824094 @default.
- W3078045561 cites W2007225104 @default.
- W3078045561 cites W2009708096 @default.
- W3078045561 cites W2011969426 @default.
- W3078045561 cites W2020599095 @default.
- W3078045561 cites W2021373833 @default.
- W3078045561 cites W2029559054 @default.
- W3078045561 cites W2034355620 @default.
- W3078045561 cites W2035293839 @default.
- W3078045561 cites W2037390777 @default.
- W3078045561 cites W2037603093 @default.
- W3078045561 cites W2038964742 @default.
- W3078045561 cites W2042378303 @default.
- W3078045561 cites W2048275890 @default.
- W3078045561 cites W2049279317 @default.
- W3078045561 cites W2049424035 @default.
- W3078045561 cites W2050630990 @default.
- W3078045561 cites W2050987515 @default.
- W3078045561 cites W2052825669 @default.
- W3078045561 cites W2053089578 @default.
- W3078045561 cites W2053133897 @default.
- W3078045561 cites W2056978939 @default.
- W3078045561 cites W2059678501 @default.
- W3078045561 cites W2060212233 @default.
- W3078045561 cites W2061478525 @default.
- W3078045561 cites W2069660062 @default.
- W3078045561 cites W2073097315 @default.
- W3078045561 cites W2076003960 @default.
- W3078045561 cites W2076780019 @default.
- W3078045561 cites W2077900057 @default.
- W3078045561 cites W2079229603 @default.
- W3078045561 cites W2086265537 @default.
- W3078045561 cites W2086582835 @default.
- W3078045561 cites W2087493271 @default.
- W3078045561 cites W2089894746 @default.
- W3078045561 cites W2091043527 @default.
- W3078045561 cites W2092839363 @default.
- W3078045561 cites W2095903180 @default.
- W3078045561 cites W2101728847 @default.
- W3078045561 cites W2105753034 @default.
- W3078045561 cites W2108934548 @default.
- W3078045561 cites W2109622516 @default.
- W3078045561 cites W2110618106 @default.
- W3078045561 cites W2114068481 @default.
- W3078045561 cites W2114263176 @default.
- W3078045561 cites W2114715558 @default.
- W3078045561 cites W2120311603 @default.
- W3078045561 cites W2126006785 @default.
- W3078045561 cites W2126271676 @default.
- W3078045561 cites W2126978393 @default.
- W3078045561 cites W2129416152 @default.
- W3078045561 cites W2130368793 @default.
- W3078045561 cites W2130656983 @default.
- W3078045561 cites W2132415682 @default.
- W3078045561 cites W2133870073 @default.
- W3078045561 cites W2134279284 @default.
- W3078045561 cites W2136855213 @default.
- W3078045561 cites W2138242641 @default.
- W3078045561 cites W2138422160 @default.
- W3078045561 cites W2142526160 @default.
- W3078045561 cites W2148164421 @default.
- W3078045561 cites W2159719917 @default.