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- W3079065590 abstract "The Jamu is one type of traditional herbal medicine that still popular among the community until now. In twenty years often found the jamu containing synthetic drugs. Drug chemical which is commonly added to this traditional herbal medicine include the class of drugs of NAISD’s namely phenylbutazone. This study was conducted to determine the possibility of presence of phenylbutazone in the Jamu. The beginning of this study by initial screening using Thin Layer Chromatography (TLC) method. The results showed that 4 of the 6 samples of the positive contain phenylbutazone based TLC method. These 4 samples were then analyzed using the Liquid Chromatography Mass Spectroscopy (LCMS) method. The stationary phase is Octadecyl Silica (C18) and the Mobile Phase are ultrapure water motion: acetonitrile (90 : 10% v/v) with isocratic elution system and positive ion mode. Based on LCMS chromatogram data, the retention time (Rf) of phenylbutazone is 1.89 minutes. The retention time of samples same with the retention time of phenylbutazone. The next approach, based on the fragmentation pattern of Mass Spectroscopy. Based on mass spectrum data, there are 2 formed fragmentation paths. The first pattern is the fragmentation process of phenylbutazone (309 m / z), forming 2-butylmalonaldehyde (129 m / z) and 1,2-diphenylhydrazine (184 m / z). The second fragmentation pattern was obtained by the Indol 3-H pathway, producing 3-butylidene-3H-indol-2-olate fragments (188 m / z) and 3H-indole-2,3-diide (114 m / z). Based on the analysis using the LCMS method, four samples containing phenylbutazone, Samples A, C, D and E. The four samples should not be allowed to be traded and consumed for violating the Regulation of the Minister of Health of the Republic of Indonesia No 006 of 2012chapter 33 and chapter 37 on the industry and traditional medicine business that traditional medicine is prohibited to contain chemicals from the isolation or synthetic drug efficacious." @default.
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- W3079065590 date "2020-08-18" @default.
- W3079065590 modified "2023-09-25" @default.
- W3079065590 title "IDENTIFIKASI DAN STUDI POLA FRAGMENTASI JAMU TERKONFIRMASI FENILBUTAZON MENGGUNAKAN LIQUID CHROMATOGRAPHY MASS SPECTROSCOPY (LCMS)" @default.
- W3079065590 doi "https://doi.org/10.36434/scientia.v10i2.349" @default.
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