Matches in SemOpenAlex for { <https://semopenalex.org/work/W3079155178> ?p ?o ?g. }
- W3079155178 endingPage "2000180" @default.
- W3079155178 startingPage "2000180" @default.
- W3079155178 abstract "The purpose of this study was to develop a PLGA-PEG-COOH- and gelatin-based microparticles (MPs) dual delivery system for release of BMP-2 and IGF-1. We made and characterized the delivery system based on its morphology, loading capacity, Encapsulation efficiency and release kinetics. Second, we examined the effects of electron beam (EB) sterilization on BMP-2 and IGF-1 loaded MPs and their biological effects. Third, we evaluated the synergistic effect of a controlled dual release of BMP-2 and IGF-1 on osteogenesis of MSCs. Encapsulation efficiency of growth factors into gelatin and PLGA-PEG-COOH MPs are in the range of 64.78% to 76.11%. E-beam sterilized growth factor delivery systems were effective in significantly promoting osteogenesis of MSCs, although E-beam sterilization decreased the bioactivity of growth factors in MPs by approximately 22%. BMP-2 release behavior from gelatin MPs/PEG hydrogel shows a faster release (52.7%) than that of IGF-1 from the PLGA-PEG-COOH MPs/PEG hydrogel (27.3%). The results demonstrate that the gelatin and PLGA-PEG-COOH MPs based delivery system could realize temporal release of therapeutic biomolecules by incorporating different growth factors into distinct microparticles. EB sterilization was an accessible method for sterilizing growth factors loaded carriers, which could pave the way for implementing growth factor delivery in clinical applications." @default.
- W3079155178 created "2020-08-24" @default.
- W3079155178 creator A5005659473 @default.
- W3079155178 creator A5040883232 @default.
- W3079155178 creator A5051755337 @default.
- W3079155178 creator A5059654764 @default.
- W3079155178 creator A5066266247 @default.
- W3079155178 creator A5074628931 @default.
- W3079155178 creator A5082280236 @default.
- W3079155178 creator A5088995116 @default.
- W3079155178 creator A5091157658 @default.
- W3079155178 date "2020-08-18" @default.
- W3079155178 modified "2023-10-17" @default.
- W3079155178 title "Development of PLGA‐PEG‐COOH and Gelatin‐Based Microparticles Dual Delivery System and E‐Beam Sterilization Effects for Controlled Release of BMP‐2 and IGF‐1" @default.
- W3079155178 cites W110939414 @default.
- W3079155178 cites W1655632696 @default.
- W3079155178 cites W1965907530 @default.
- W3079155178 cites W1968601496 @default.
- W3079155178 cites W1968996065 @default.
- W3079155178 cites W1974200766 @default.
- W3079155178 cites W1987164950 @default.
- W3079155178 cites W1994135330 @default.
- W3079155178 cites W1996975723 @default.
- W3079155178 cites W1997107243 @default.
- W3079155178 cites W2001821470 @default.
- W3079155178 cites W2005632777 @default.
- W3079155178 cites W2005656975 @default.
- W3079155178 cites W2021541380 @default.
- W3079155178 cites W2021714182 @default.
- W3079155178 cites W2023031848 @default.
- W3079155178 cites W2028305494 @default.
- W3079155178 cites W2033390870 @default.
- W3079155178 cites W2039618142 @default.
- W3079155178 cites W2040947007 @default.
- W3079155178 cites W2042249858 @default.
- W3079155178 cites W2045895186 @default.
- W3079155178 cites W2048227994 @default.
- W3079155178 cites W2053307155 @default.
- W3079155178 cites W2055747327 @default.
- W3079155178 cites W2064230565 @default.
- W3079155178 cites W2070887446 @default.
- W3079155178 cites W2088219624 @default.
- W3079155178 cites W2095752286 @default.
- W3079155178 cites W2098313469 @default.
- W3079155178 cites W2128603683 @default.
- W3079155178 cites W2129358933 @default.
- W3079155178 cites W2249913356 @default.
- W3079155178 cites W2303626751 @default.
- W3079155178 cites W2405847408 @default.
- W3079155178 cites W2650995278 @default.
- W3079155178 cites W2765199942 @default.
- W3079155178 cites W2783319961 @default.
- W3079155178 cites W2804921082 @default.
- W3079155178 cites W2889585934 @default.
- W3079155178 cites W4244175765 @default.
- W3079155178 doi "https://doi.org/10.1002/ppsc.202000180" @default.
- W3079155178 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7771709" @default.
- W3079155178 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33384477" @default.
- W3079155178 hasPublicationYear "2020" @default.
- W3079155178 type Work @default.
- W3079155178 sameAs 3079155178 @default.
- W3079155178 citedByCount "9" @default.
- W3079155178 countsByYear W30791551782021 @default.
- W3079155178 countsByYear W30791551782022 @default.
- W3079155178 countsByYear W30791551782023 @default.
- W3079155178 crossrefType "journal-article" @default.
- W3079155178 hasAuthorship W3079155178A5005659473 @default.
- W3079155178 hasAuthorship W3079155178A5040883232 @default.
- W3079155178 hasAuthorship W3079155178A5051755337 @default.
- W3079155178 hasAuthorship W3079155178A5059654764 @default.
- W3079155178 hasAuthorship W3079155178A5066266247 @default.
- W3079155178 hasAuthorship W3079155178A5074628931 @default.
- W3079155178 hasAuthorship W3079155178A5082280236 @default.
- W3079155178 hasAuthorship W3079155178A5088995116 @default.
- W3079155178 hasAuthorship W3079155178A5091157658 @default.
- W3079155178 hasBestOaLocation W30791551782 @default.
- W3079155178 hasConcept C10138342 @default.
- W3079155178 hasConcept C127413603 @default.
- W3079155178 hasConcept C136229726 @default.
- W3079155178 hasConcept C144133560 @default.
- W3079155178 hasConcept C148761745 @default.
- W3079155178 hasConcept C185592680 @default.
- W3079155178 hasConcept C202751555 @default.
- W3079155178 hasConcept C2776988154 @default.
- W3079155178 hasConcept C2778823387 @default.
- W3079155178 hasConcept C2780165375 @default.
- W3079155178 hasConcept C2983812674 @default.
- W3079155178 hasConcept C30352789 @default.
- W3079155178 hasConcept C42360764 @default.
- W3079155178 hasConcept C536366893 @default.
- W3079155178 hasConcept C54400483 @default.
- W3079155178 hasConcept C55493867 @default.
- W3079155178 hasConcept C71924100 @default.
- W3079155178 hasConceptScore W3079155178C10138342 @default.
- W3079155178 hasConceptScore W3079155178C127413603 @default.
- W3079155178 hasConceptScore W3079155178C136229726 @default.
- W3079155178 hasConceptScore W3079155178C144133560 @default.
- W3079155178 hasConceptScore W3079155178C148761745 @default.