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- W307974 abstract "The effect of activation of 1and 1-opioid receptor (OR) on the tolerance of isolated perfused rat heart to global ischemia and reperfusion were studied. It was established that stimulation of cardiac 1and 1-OR by adding agonists U-50,488 encourage the decrease of reperfusion release of creatine kinase from heart compared to control group. Occupancy of 1-OR by DPDPE did not affect the cAMP levels in the heart before and after ischemia. Occupancy of 1-OR by U-50,488 had no effect on the cAMP levels in the myocardium pre-ischemia period but reduced the cAMP content in reperfusion period in comparison with control group. The pretreatment with inhibitor of Ca2+-ATPase of sarcoplasmic reticulum cyclopiazonic acid completely abolished the cardioprotective effect of 1-OR agonist DPDPE. It was proposed that cardioprotective effect of 1-OR stimulation is dependent on the decrease in cAMP levels in the heart but Ca2+-ATPase of sarcoplasmic reticulum is involved in the cardioprotective effect of 1-OR activation." @default.
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- W307974 date "2011-01-01" @default.
- W307974 modified "2023-09-26" @default.
- W307974 title "Внутриклеточный кальций и цАМФ опосредуют кардиотропные эффекты агонистов опиоидных рецепторов" @default.
- W307974 hasPublicationYear "2011" @default.
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