Matches in SemOpenAlex for { <https://semopenalex.org/work/W3079804098> ?p ?o ?g. }
- W3079804098 endingPage "194626" @default.
- W3079804098 startingPage "194626" @default.
- W3079804098 abstract "General Control Non-repressed 5 protein (GCN5), encoded by the mammalian gene Kat2a, is the first histone acetyltransferase discovered to link histone acetylation to transcriptional activation [1]. The enzymatic activity of GCN5 is linked to cellular metabolic and energetic states regulating gene expression programs. GCN5 has a major impact on energy metabolism by i) sensing acetyl-CoA, a central metabolite and substrate of the GCN5 catalytic reaction, and ii) acetylating proteins such as PGC-1α, a transcriptional coactivator that controls genes linked to energy metabolism and mitochondrial biogenesis. PGC-1α is biochemically associated with the GCN5 protein complex during active metabolic reprogramming. In the first part of the review, we examine how metabolism can change GCN5-dependent histone acetylation to regulate gene expression to adapt cells. In the second part, we summarize the GCN5 function as a nutrient sensor, focusing on non-histone protein acetylation, mainly the metabolic role of PGC-1α acetylation across different tissues." @default.
- W3079804098 created "2020-08-24" @default.
- W3079804098 creator A5022983645 @default.
- W3079804098 creator A5070153869 @default.
- W3079804098 date "2021-02-01" @default.
- W3079804098 modified "2023-10-16" @default.
- W3079804098 title "GCN5 acetyltransferase in cellular energetic and metabolic processes" @default.
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