Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080092311> ?p ?o ?g. }
- W3080092311 endingPage "708" @default.
- W3080092311 startingPage "708" @default.
- W3080092311 abstract "Central nervous system invasion by bacteria of the genus Brucella results in an inflammatory disorder called neurobrucellosis. A common feature associated with this pathology is blood–brain barrier (BBB) activation. However, the underlying mechanisms involved with such BBB activation remain unknown. The aim of this work was to investigate the role of Brucella abortus-stimulated platelets on human brain microvascular endothelial cell (HBMEC) activation. Platelets enhanced HBMEC activation in response to B. abortus infection. Furthermore, supernatants from B. abortus-stimulated platelets also activated brain endothelial cells, inducing increased secretion of IL-6, IL-8, CCL-2 as well as ICAM-1 and CD40 upregulation on HBMEC compared with supernatants from unstimulated platelets. Outer membrane protein 19, a B. abortus lipoprotein, recapitulated B. abortus-mediated activation of HBMECs by platelets. In addition, supernatants from B. abortus-activated platelets promoted transendothelial migration of neutrophils and monocytes. Finally, using a pharmacological inhibitor, we demonstrated that the Erk1/2 pathway is involved in the endothelial activation induced by B. abortus-stimulated platelets and also in transendothelial migration of neutrophils. These results describe a mechanism whereby B. abortus-stimulated platelets induce endothelial cell activation, promoting neutrophils and monocytes to traverse the BBB probably contributing to the inflammatory pathology of neurobrucellosis." @default.
- W3080092311 created "2020-09-01" @default.
- W3080092311 creator A5002257874 @default.
- W3080092311 creator A5015192058 @default.
- W3080092311 creator A5016165244 @default.
- W3080092311 creator A5018272765 @default.
- W3080092311 creator A5031382042 @default.
- W3080092311 creator A5065910864 @default.
- W3080092311 creator A5074509030 @default.
- W3080092311 creator A5088093222 @default.
- W3080092311 date "2020-08-27" @default.
- W3080092311 modified "2023-10-14" @default.
- W3080092311 title "Brucella abortus-Stimulated Platelets Activate Brain Microvascular Endothelial Cells Increasing Cell Transmigration through the Erk1/2 Pathway" @default.
- W3080092311 cites W123566684 @default.
- W3080092311 cites W1547736903 @default.
- W3080092311 cites W1561516029 @default.
- W3080092311 cites W1574571139 @default.
- W3080092311 cites W1578542647 @default.
- W3080092311 cites W1723097356 @default.
- W3080092311 cites W182462426 @default.
- W3080092311 cites W1962125373 @default.
- W3080092311 cites W1971813534 @default.
- W3080092311 cites W1976954262 @default.
- W3080092311 cites W1980056037 @default.
- W3080092311 cites W1984399406 @default.
- W3080092311 cites W1986438546 @default.
- W3080092311 cites W1987677893 @default.
- W3080092311 cites W1988212011 @default.
- W3080092311 cites W1990295868 @default.
- W3080092311 cites W2005796205 @default.
- W3080092311 cites W2006919110 @default.
- W3080092311 cites W2008375049 @default.
- W3080092311 cites W2024885545 @default.
- W3080092311 cites W2051710983 @default.
- W3080092311 cites W2065387895 @default.
- W3080092311 cites W2069786094 @default.
- W3080092311 cites W2070207411 @default.
- W3080092311 cites W2071237033 @default.
- W3080092311 cites W2074413337 @default.
- W3080092311 cites W2080671503 @default.
- W3080092311 cites W2104998148 @default.
- W3080092311 cites W2117691576 @default.
- W3080092311 cites W2134767973 @default.
- W3080092311 cites W2138651252 @default.
- W3080092311 cites W2146582952 @default.
- W3080092311 cites W2148650107 @default.
- W3080092311 cites W2150913549 @default.
- W3080092311 cites W2152510100 @default.
- W3080092311 cites W2158966093 @default.
- W3080092311 cites W2167007850 @default.
- W3080092311 cites W2168377871 @default.
- W3080092311 cites W2171783221 @default.
- W3080092311 cites W2184527702 @default.
- W3080092311 cites W2229118680 @default.
- W3080092311 cites W2298338339 @default.
- W3080092311 cites W2346172181 @default.
- W3080092311 cites W2606385352 @default.
- W3080092311 cites W2615170291 @default.
- W3080092311 cites W2730423879 @default.
- W3080092311 cites W2801707568 @default.
- W3080092311 cites W2806299751 @default.
- W3080092311 cites W3040267312 @default.
- W3080092311 doi "https://doi.org/10.3390/pathogens9090708" @default.
- W3080092311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7558107" @default.
- W3080092311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32867217" @default.
- W3080092311 hasPublicationYear "2020" @default.
- W3080092311 type Work @default.
- W3080092311 sameAs 3080092311 @default.
- W3080092311 citedByCount "4" @default.
- W3080092311 countsByYear W30800923112021 @default.
- W3080092311 countsByYear W30800923112022 @default.
- W3080092311 countsByYear W30800923112023 @default.
- W3080092311 crossrefType "journal-article" @default.
- W3080092311 hasAuthorship W3080092311A5002257874 @default.
- W3080092311 hasAuthorship W3080092311A5015192058 @default.
- W3080092311 hasAuthorship W3080092311A5016165244 @default.
- W3080092311 hasAuthorship W3080092311A5018272765 @default.
- W3080092311 hasAuthorship W3080092311A5031382042 @default.
- W3080092311 hasAuthorship W3080092311A5065910864 @default.
- W3080092311 hasAuthorship W3080092311A5074509030 @default.
- W3080092311 hasAuthorship W3080092311A5088093222 @default.
- W3080092311 hasBestOaLocation W30800923111 @default.
- W3080092311 hasConcept C104317684 @default.
- W3080092311 hasConcept C123012128 @default.
- W3080092311 hasConcept C127561419 @default.
- W3080092311 hasConcept C134018914 @default.
- W3080092311 hasConcept C202751555 @default.
- W3080092311 hasConcept C203014093 @default.
- W3080092311 hasConcept C3018697912 @default.
- W3080092311 hasConcept C49039625 @default.
- W3080092311 hasConcept C55493867 @default.
- W3080092311 hasConcept C86803240 @default.
- W3080092311 hasConcept C89560881 @default.
- W3080092311 hasConcept C95444343 @default.
- W3080092311 hasConceptScore W3080092311C104317684 @default.
- W3080092311 hasConceptScore W3080092311C123012128 @default.
- W3080092311 hasConceptScore W3080092311C127561419 @default.
- W3080092311 hasConceptScore W3080092311C134018914 @default.