Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080093217> ?p ?o ?g. }
- W3080093217 endingPage "13256" @default.
- W3080093217 startingPage "13239" @default.
- W3080093217 abstract "Lactic acid (LA) is a byproduct of glycolysis resulting from intense exercise or a metabolic defect in aerobic processes. LA metabolism is essential to prevent lactic acidosis, but the mechanism through which LA regulates its own metabolism is largely unknown. Here, we identified a LA-responsive protein, named LRPGC1, which has a distinct role from PGC1α, a key metabolic regulator, and report that LRPGC1 particularly mediates LA response to activate liver LA metabolism. Following LA stimulation, LRPGC1, but not PGC1α, translocates from the cytoplasm to the nucleus through deactivation of nuclear export signals, interacts with the nuclear receptor ERRγ, and upregulates TFAM, which ensures mitochondrial biogenesis. Knockout of PGC1 gene in HepG2 hepatocarcinoma cells decreased the LA consumption and TFAM expression, which were rescued by LRPGC1 expression, but not by PGC1α. These LRPGC1-induced effects were mediated by ERRγ, concomitantly with mitochondrial activation. The response element for LRPGC1/ERRγ signaling pathway was identified in TFAM promoter. Notably, the survival rate of a mouse model of lactic acidosis was reduced by the liver-targeted silencing of Lrpgc1, while it was significantly ameliorated by the pharmacological activation of ERRγ. These findings demonstrate LA-responsive transactivation via LRPGC1 that highlight an intrinsic molecular mechanism for LA homeostasis." @default.
- W3080093217 created "2020-09-01" @default.
- W3080093217 creator A5030086603 @default.
- W3080093217 creator A5032113813 @default.
- W3080093217 creator A5044391914 @default.
- W3080093217 date "2020-08-26" @default.
- W3080093217 modified "2023-10-16" @default.
- W3080093217 title "Novel metabolic system for lactic acid via LRPGC1/ERRγ signaling pathway" @default.
- W3080093217 cites W1493035598 @default.
- W3080093217 cites W1548299326 @default.
- W3080093217 cites W1618691523 @default.
- W3080093217 cites W1817127090 @default.
- W3080093217 cites W1963994022 @default.
- W3080093217 cites W1966985989 @default.
- W3080093217 cites W1968197570 @default.
- W3080093217 cites W1971082641 @default.
- W3080093217 cites W1972038003 @default.
- W3080093217 cites W1973769775 @default.
- W3080093217 cites W1973939264 @default.
- W3080093217 cites W1976658071 @default.
- W3080093217 cites W1977339956 @default.
- W3080093217 cites W1979753452 @default.
- W3080093217 cites W1981574178 @default.
- W3080093217 cites W1984649617 @default.
- W3080093217 cites W1986179792 @default.
- W3080093217 cites W1988263640 @default.
- W3080093217 cites W1989083413 @default.
- W3080093217 cites W1990579890 @default.
- W3080093217 cites W1994160842 @default.
- W3080093217 cites W1995263538 @default.
- W3080093217 cites W1996821192 @default.
- W3080093217 cites W2000065704 @default.
- W3080093217 cites W2008632158 @default.
- W3080093217 cites W2013355489 @default.
- W3080093217 cites W2016153572 @default.
- W3080093217 cites W2017011351 @default.
- W3080093217 cites W2019671050 @default.
- W3080093217 cites W2023574559 @default.
- W3080093217 cites W2029306713 @default.
- W3080093217 cites W2036443530 @default.
- W3080093217 cites W2041155980 @default.
- W3080093217 cites W2044782567 @default.
- W3080093217 cites W2048589552 @default.
- W3080093217 cites W2049866636 @default.
- W3080093217 cites W2052947058 @default.
- W3080093217 cites W2053765200 @default.
- W3080093217 cites W2054635243 @default.
- W3080093217 cites W2059044841 @default.
- W3080093217 cites W2060577181 @default.
- W3080093217 cites W2066145562 @default.
- W3080093217 cites W2072945343 @default.
- W3080093217 cites W2079871357 @default.
- W3080093217 cites W2081703555 @default.
- W3080093217 cites W2086554547 @default.
- W3080093217 cites W2090198447 @default.
- W3080093217 cites W2100459468 @default.
- W3080093217 cites W2110799342 @default.
- W3080093217 cites W2113384172 @default.
- W3080093217 cites W2113515610 @default.
- W3080093217 cites W2115741560 @default.
- W3080093217 cites W2116230208 @default.
- W3080093217 cites W2119554992 @default.
- W3080093217 cites W2120957537 @default.
- W3080093217 cites W2131681843 @default.
- W3080093217 cites W2141789735 @default.
- W3080093217 cites W2142459690 @default.
- W3080093217 cites W2153864108 @default.
- W3080093217 cites W2164499983 @default.
- W3080093217 cites W2164508393 @default.
- W3080093217 cites W2168603964 @default.
- W3080093217 cites W2169458819 @default.
- W3080093217 cites W2171969981 @default.
- W3080093217 cites W2326389904 @default.
- W3080093217 cites W2340362155 @default.
- W3080093217 cites W2468001067 @default.
- W3080093217 cites W2522804738 @default.
- W3080093217 cites W2576171254 @default.
- W3080093217 cites W2762717139 @default.
- W3080093217 cites W2804153840 @default.
- W3080093217 cites W2888174673 @default.
- W3080093217 cites W2980464418 @default.
- W3080093217 cites W2982216374 @default.
- W3080093217 cites W4230068322 @default.
- W3080093217 cites W4233323540 @default.
- W3080093217 cites W4245367233 @default.
- W3080093217 doi "https://doi.org/10.1096/fj.202000492r" @default.
- W3080093217 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32851675" @default.
- W3080093217 hasPublicationYear "2020" @default.
- W3080093217 type Work @default.
- W3080093217 sameAs 3080093217 @default.
- W3080093217 citedByCount "5" @default.
- W3080093217 countsByYear W30800932172021 @default.
- W3080093217 countsByYear W30800932172022 @default.
- W3080093217 countsByYear W30800932172023 @default.
- W3080093217 crossrefType "journal-article" @default.
- W3080093217 hasAuthorship W3080093217A5030086603 @default.
- W3080093217 hasAuthorship W3080093217A5032113813 @default.
- W3080093217 hasAuthorship W3080093217A5044391914 @default.