FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080114847> ?p ?o ?g. }

• W3080114847 endingPage "768" @default.
• W3080114847 startingPage "761" @default.
• W3080114847 abstract "Background: Sublingual buprenorphine-naloxone (BUP-NX), an FDA-approved treatment for opioid use disorder (OUD), combines buprenorphine (a partial mu/kappa agonist) with naloxone (a mu/ kappa antagonist). Extended-release injection naltrexone (XR-NTX; a mu receptor antagonist and kappa receptor partial agonist) is also an FDA-approved treatment for OUD. However, while some patients respond well to these medications, many others leave treatment and relapse.Objectives: Determine whether gene variants in the opioid gene system are associated with better or worse treatment response.Methods: In a 24-week, multisite, randomized, comparative effectiveness trial of daily, sublingual self-administration of BUP-NX versus monthly injection of XR-NTX conducted in the National Drug Abuse Clinical Trials Network, DNA was collected and four opioid gene variants were evaluated: (1) mu opioid receptor 118A>G; (2) 68-bp repeat in prodynorphin; (3) prodynorphin SNP rs910080; and (4) kappa opioid receptor SNP rs6473797. In non-Hispanic Caucasians (N = 334), two outcomes measures were assessed: received first dose (yes/no) and received last dose (yes/no). Separate logistic regressions were used to model each outcome measure as a function of treatment (XR-NTX vs BUP-NX), each gene variant, and their interaction.Results: There were no significant main effects of gene variant on receiving first dose or last dose. There were also no significant gene variant by treatment interactions.Conclusions: The outcome of treatment of OUD with medications is likely a complex function of multiple factors, including environmental, psychosocial, and possibly genetic, such that major effects of genetic variants may be unlikely." @default.
• W3080114847 created "2020-09-01" @default.
• W3080114847 creator A5000017329 @default.
• W3080114847 creator A5023564472 @default.
• W3080114847 creator A5039487284 @default.
• W3080114847 creator A5042072885 @default.
• W3080114847 creator A5042175466 @default.
• W3080114847 creator A5052891328 @default.
• W3080114847 creator A5071920736 @default.
• W3080114847 creator A5073707428 @default.
• W3080114847 creator A5079969867 @default.
• W3080114847 creator A5090505314 @default.
• W3080114847 date "2020-08-27" @default.
• W3080114847 modified "2023-10-14" @default.
• W3080114847 title "Variants of opioid genes and response to treatment of opioid use disorder with buprenorphine-naloxone versus extended-release naltrexone in Caucasians" @default.
• W3080114847 cites W1565736591 @default.
• W3080114847 cites W1616671031 @default.
• W3080114847 cites W1989488351 @default.
• W3080114847 cites W2012743573 @default.
• W3080114847 cites W2019528567 @default.
• W3080114847 cites W2053338735 @default.
• W3080114847 cites W2054458932 @default.
• W3080114847 cites W2080253238 @default.
• W3080114847 cites W2083332683 @default.
• W3080114847 cites W2083370805 @default.
• W3080114847 cites W2099072801 @default.
• W3080114847 cites W2118342649 @default.
• W3080114847 cites W2119920227 @default.
• W3080114847 cites W2125202254 @default.
• W3080114847 cites W2132974770 @default.
• W3080114847 cites W2146202549 @default.
• W3080114847 cites W2149717129 @default.
• W3080114847 cites W2164678034 @default.
• W3080114847 cites W2173844711 @default.
• W3080114847 cites W2327042539 @default.
• W3080114847 cites W2607023254 @default.
• W3080114847 cites W2768214444 @default.
• W3080114847 doi "https://doi.org/10.1080/00952990.2020.1797064" @default.
• W3080114847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8376218" @default.
• W3080114847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32851876" @default.
• W3080114847 hasPublicationYear "2020" @default.
• W3080114847 type Work @default.
• W3080114847 sameAs 3080114847 @default.
• W3080114847 citedByCount "3" @default.
• W3080114847 countsByYear W30801148472021 @default.
• W3080114847 countsByYear W30801148472022 @default.
• W3080114847 countsByYear W30801148472023 @default.
• W3080114847 crossrefType "journal-article" @default.
• W3080114847 hasAuthorship W3080114847A5000017329 @default.
• W3080114847 hasAuthorship W3080114847A5023564472 @default.
• W3080114847 hasAuthorship W3080114847A5039487284 @default.
• W3080114847 hasAuthorship W3080114847A5042072885 @default.
• W3080114847 hasAuthorship W3080114847A5042175466 @default.
• W3080114847 hasAuthorship W3080114847A5052891328 @default.
• W3080114847 hasAuthorship W3080114847A5071920736 @default.
• W3080114847 hasAuthorship W3080114847A5073707428 @default.
• W3080114847 hasAuthorship W3080114847A5079969867 @default.
• W3080114847 hasAuthorship W3080114847A5090505314 @default.
• W3080114847 hasBestOaLocation W30801148471 @default.
• W3080114847 hasConcept C126322002 @default.
• W3080114847 hasConcept C151077648 @default.
• W3080114847 hasConcept C170493617 @default.
• W3080114847 hasConcept C184389661 @default.
• W3080114847 hasConcept C2775962371 @default.
• W3080114847 hasConcept C2777972943 @default.
• W3080114847 hasConcept C2778750930 @default.
• W3080114847 hasConcept C2778938600 @default.
• W3080114847 hasConcept C2778949969 @default.
• W3080114847 hasConcept C2779418921 @default.
• W3080114847 hasConcept C2781063702 @default.
• W3080114847 hasConcept C58732023 @default.
• W3080114847 hasConcept C71924100 @default.
• W3080114847 hasConcept C88016717 @default.
• W3080114847 hasConcept C98274493 @default.
• W3080114847 hasConceptScore W3080114847C126322002 @default.
• W3080114847 hasConceptScore W3080114847C151077648 @default.
• W3080114847 hasConceptScore W3080114847C170493617 @default.
• W3080114847 hasConceptScore W3080114847C184389661 @default.
• W3080114847 hasConceptScore W3080114847C2775962371 @default.
• W3080114847 hasConceptScore W3080114847C2777972943 @default.
• W3080114847 hasConceptScore W3080114847C2778750930 @default.
• W3080114847 hasConceptScore W3080114847C2778938600 @default.
• W3080114847 hasConceptScore W3080114847C2778949969 @default.
• W3080114847 hasConceptScore W3080114847C2779418921 @default.
• W3080114847 hasConceptScore W3080114847C2781063702 @default.
• W3080114847 hasConceptScore W3080114847C58732023 @default.
• W3080114847 hasConceptScore W3080114847C71924100 @default.
• W3080114847 hasConceptScore W3080114847C88016717 @default.
• W3080114847 hasConceptScore W3080114847C98274493 @default.
• W3080114847 hasFunder F4320308854 @default.
• W3080114847 hasFunder F4320337347 @default.
• W3080114847 hasIssue "6" @default.
• W3080114847 hasLocation W30801148471 @default.
• W3080114847 hasLocation W30801148472 @default.
• W3080114847 hasLocation W30801148473 @default.
• W3080114847 hasLocation W30801148474 @default.
• W3080114847 hasOpenAccess W3080114847 @default.
• W3080114847 hasPrimaryLocation W30801148471 @default.

• next