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- W3080136168 endingPage "116981" @default.
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- W3080136168 abstract "Peripheral nerve injuries mainly occur in the extremities and result in functional deficits, and recovery after microsurgical repair is slow (<1 mm/day) and frustrating. To improve the results of nerve repair, it is crucial to promote local Schwann cell (SC) function, neurite outgrowth, and to reduce perineural adhesion. In this study, a nerve wrap electrospun with Bletilla striata polysaccharide (BSP) and waterborne polyurethane (WPU) was designed to wrap around the repaired nerve to achieve the goal. In SC proliferation/migration tests and neurite outgrowth assay, BSP/WPU revealed considerable improvement. In rabbit sciatic nerve repair model, BSP/WPU exhibited significantly higher compound muscle action potential, muscle contraction force, and reduced perineural adhesion. The downstream fascicles of the BSP/WPU group exhibited a 50 % increase in diameter and 100 % increase in myelin thickness compared with the control group. In vitro and in vivo experiments indicated the positive effect of BSP/WPU nerve wrap on nerve regeneration." @default.
- W3080136168 created "2020-09-01" @default.
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- W3080136168 creator A5061246570 @default.
- W3080136168 date "2020-12-01" @default.
- W3080136168 modified "2023-10-16" @default.
- W3080136168 title "An electrospun nerve wrap comprising Bletilla striata polysaccharide with dual function for nerve regeneration and scar prevention" @default.
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- W3080136168 doi "https://doi.org/10.1016/j.carbpol.2020.116981" @default.
- W3080136168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33049868" @default.
- W3080136168 hasPublicationYear "2020" @default.
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