Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080145142> ?p ?o ?g. }
- W3080145142 endingPage "7374" @default.
- W3080145142 startingPage "7363" @default.
- W3080145142 abstract "Abstract Background While open‐label randomized controlled trials (RCT) are common in oncology, some concerns have been expressed with regard to Patient‐Reported Outcomes (PRO)‐based claims stemming from these studies. We aimed to investigate the impact of open‐label design in the context of prostate cancer (PCa) RCTs with PRO data. Methods Randomized controlled trials of PCa with a PRO endpoint published between 2004 and 2018 were considered. RCTs were systematically evaluated on the basis of previously defined criteria, including international PRO reporting quality standards and the Cochrane Collaboration's tool for assessing Risk of Bias. The rate of concordance was estimated and compared between traditional clinical outcomes (eg, survival or tumor response) and PRO in open and blinded RCTs. Results We identified 110 RCTs published between 2004 and 2018, of which 62% (n = 68) were open‐label. The general characteristics of PCa RCTs were not different according to their design (open‐label vs blinded). The proportion of PCa RCTs with high‐quality PRO reporting was not different between open‐label RCTs and blinded RCTs (41.2% vs 38.1%; P = .75). No statistically significant difference was found between PRO results and concordance with traditional clinical outcomes according to the study design. Conclusion Our findings suggest that there is no evidence of significant bias for PROs due to the absence of blinding in the context of PCa RCTs. Further analyses should be conducted in other cancer disease sites." @default.
- W3080145142 created "2020-09-01" @default.
- W3080145142 creator A5003798935 @default.
- W3080145142 creator A5003951535 @default.
- W3080145142 creator A5012447228 @default.
- W3080145142 creator A5025300365 @default.
- W3080145142 creator A5044346439 @default.
- W3080145142 creator A5064653896 @default.
- W3080145142 creator A5079351370 @default.
- W3080145142 date "2020-08-26" @default.
- W3080145142 modified "2023-09-25" @default.
- W3080145142 title "Investigating the impact of open label design on patient‐reported outcome results in prostate cancer randomized controlled trials" @default.
- W3080145142 cites W1458630001 @default.
- W3080145142 cites W1537213946 @default.
- W3080145142 cites W1989287434 @default.
- W3080145142 cites W1990681363 @default.
- W3080145142 cites W2006175454 @default.
- W3080145142 cites W2015818865 @default.
- W3080145142 cites W2070309415 @default.
- W3080145142 cites W2072805665 @default.
- W3080145142 cites W2084061645 @default.
- W3080145142 cites W2087351488 @default.
- W3080145142 cites W2090295250 @default.
- W3080145142 cites W2096260602 @default.
- W3080145142 cites W2097618916 @default.
- W3080145142 cites W2097939049 @default.
- W3080145142 cites W2098923148 @default.
- W3080145142 cites W2101001966 @default.
- W3080145142 cites W2102355184 @default.
- W3080145142 cites W2104516446 @default.
- W3080145142 cites W2123874025 @default.
- W3080145142 cites W2145043534 @default.
- W3080145142 cites W2147802232 @default.
- W3080145142 cites W2160795579 @default.
- W3080145142 cites W2339162560 @default.
- W3080145142 cites W2413118791 @default.
- W3080145142 cites W2519027667 @default.
- W3080145142 cites W2523715715 @default.
- W3080145142 cites W2534459715 @default.
- W3080145142 cites W2601473067 @default.
- W3080145142 cites W2601864730 @default.
- W3080145142 cites W2740979023 @default.
- W3080145142 cites W2755487333 @default.
- W3080145142 cites W2781868205 @default.
- W3080145142 cites W2782908833 @default.
- W3080145142 cites W2885738414 @default.
- W3080145142 cites W2886632102 @default.
- W3080145142 cites W2888017152 @default.
- W3080145142 cites W2904103135 @default.
- W3080145142 cites W2904810040 @default.
- W3080145142 cites W2910830708 @default.
- W3080145142 cites W2914386106 @default.
- W3080145142 cites W2915228510 @default.
- W3080145142 cites W4250968058 @default.
- W3080145142 doi "https://doi.org/10.1002/cam4.3335" @default.
- W3080145142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7571808" @default.
- W3080145142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32846465" @default.
- W3080145142 hasPublicationYear "2020" @default.
- W3080145142 type Work @default.
- W3080145142 sameAs 3080145142 @default.
- W3080145142 citedByCount "16" @default.
- W3080145142 countsByYear W30801451422021 @default.
- W3080145142 countsByYear W30801451422022 @default.
- W3080145142 countsByYear W30801451422023 @default.
- W3080145142 crossrefType "journal-article" @default.
- W3080145142 hasAuthorship W3080145142A5003798935 @default.
- W3080145142 hasAuthorship W3080145142A5003951535 @default.
- W3080145142 hasAuthorship W3080145142A5012447228 @default.
- W3080145142 hasAuthorship W3080145142A5025300365 @default.
- W3080145142 hasAuthorship W3080145142A5044346439 @default.
- W3080145142 hasAuthorship W3080145142A5064653896 @default.
- W3080145142 hasAuthorship W3080145142A5079351370 @default.
- W3080145142 hasBestOaLocation W30801451421 @default.
- W3080145142 hasConcept C121608353 @default.
- W3080145142 hasConcept C126322002 @default.
- W3080145142 hasConcept C143998085 @default.
- W3080145142 hasConcept C151730666 @default.
- W3080145142 hasConcept C160798450 @default.
- W3080145142 hasConcept C168563851 @default.
- W3080145142 hasConcept C203092338 @default.
- W3080145142 hasConcept C2771230 @default.
- W3080145142 hasConcept C2779343474 @default.
- W3080145142 hasConcept C2780192828 @default.
- W3080145142 hasConcept C2780439572 @default.
- W3080145142 hasConcept C71924100 @default.
- W3080145142 hasConcept C86803240 @default.
- W3080145142 hasConcept C95190672 @default.
- W3080145142 hasConceptScore W3080145142C121608353 @default.
- W3080145142 hasConceptScore W3080145142C126322002 @default.
- W3080145142 hasConceptScore W3080145142C143998085 @default.
- W3080145142 hasConceptScore W3080145142C151730666 @default.
- W3080145142 hasConceptScore W3080145142C160798450 @default.
- W3080145142 hasConceptScore W3080145142C168563851 @default.
- W3080145142 hasConceptScore W3080145142C203092338 @default.
- W3080145142 hasConceptScore W3080145142C2771230 @default.
- W3080145142 hasConceptScore W3080145142C2779343474 @default.
- W3080145142 hasConceptScore W3080145142C2780192828 @default.
- W3080145142 hasConceptScore W3080145142C2780439572 @default.