Matches in SemOpenAlex for { <https://semopenalex.org/work/W3080169204> ?p ?o ?g. }
- W3080169204 endingPage "447" @default.
- W3080169204 startingPage "431" @default.
- W3080169204 abstract "The cholinergic anti-inflammatory reflex (CAIR) represents an important homeostatic regulatory mechanism for sensing and controlling the body's response to inflammatory stimuli. Vagovagal reflexes are an integral component of CAIR whose anti-inflammatory effects are mediated by acetylcholine (ACh) acting at α7 nicotinic acetylcholine receptors (α7nAChR) located on cells of the immune system. Recently, it is appreciated that CAIR and α7nAChR also participate in the control of metabolic homeostasis. This has led to the understanding that defective vagovagal reflex circuitry underlying CAIR might explain the coexistence of obesity, diabetes, and inflammation in the metabolic syndrome. Thus, there is renewed interest in the α7nAChR that mediates CAIR, particularly from the standpoint of therapeutics. Of special note is the recent finding that α7nAChR agonist GTS-21 acts at L-cells of the distal intestine to stimulate the release of two glucoregulatory and anorexigenic hormones: glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). Furthermore, α7nAChR agonist PNU 282987 exerts trophic factor-like actions to support pancreatic β-cell survival under conditions of stress resembling diabetes. This review provides an overview of α7nAChR function as it pertains to CAIR, vagovagal reflexes, and metabolic homeostasis. We also consider the possible usefulness of α7nAChR agonists for treatment of obesity, diabetes, and inflammation." @default.
- W3080169204 created "2020-09-01" @default.
- W3080169204 creator A5020235785 @default.
- W3080169204 creator A5029474081 @default.
- W3080169204 creator A5034310331 @default.
- W3080169204 creator A5053141753 @default.
- W3080169204 creator A5054552956 @default.
- W3080169204 creator A5058178334 @default.
- W3080169204 creator A5059127672 @default.
- W3080169204 creator A5061055387 @default.
- W3080169204 date "2020-08-26" @default.
- W3080169204 modified "2023-10-17" @default.
- W3080169204 title "Therapeutic potential of α7 nicotinic acetylcholine receptor agonists to combat obesity, diabetes, and inflammation" @default.
- W3080169204 cites W100190743 @default.
- W3080169204 cites W140545298 @default.
- W3080169204 cites W145765351 @default.
- W3080169204 cites W1492946553 @default.
- W3080169204 cites W1513183398 @default.
- W3080169204 cites W1514693175 @default.
- W3080169204 cites W1533867282 @default.
- W3080169204 cites W1533939474 @default.
- W3080169204 cites W1542237172 @default.
- W3080169204 cites W1542715374 @default.
- W3080169204 cites W1611441558 @default.
- W3080169204 cites W1694069654 @default.
- W3080169204 cites W1816880077 @default.
- W3080169204 cites W1847960242 @default.
- W3080169204 cites W1859480879 @default.
- W3080169204 cites W1866455211 @default.
- W3080169204 cites W1900806927 @default.
- W3080169204 cites W1945952457 @default.
- W3080169204 cites W1966147290 @default.
- W3080169204 cites W1968928208 @default.
- W3080169204 cites W1970043402 @default.
- W3080169204 cites W1974306203 @default.
- W3080169204 cites W1975537939 @default.
- W3080169204 cites W1977603207 @default.
- W3080169204 cites W1981020037 @default.
- W3080169204 cites W1985027041 @default.
- W3080169204 cites W1985093720 @default.
- W3080169204 cites W1986356926 @default.
- W3080169204 cites W1986959183 @default.
- W3080169204 cites W1987548081 @default.
- W3080169204 cites W1988338937 @default.
- W3080169204 cites W1988807128 @default.
- W3080169204 cites W1989950718 @default.
- W3080169204 cites W1992372874 @default.
- W3080169204 cites W1993072101 @default.
- W3080169204 cites W1993337719 @default.
- W3080169204 cites W1995846564 @default.
- W3080169204 cites W1996121363 @default.
- W3080169204 cites W1999114713 @default.
- W3080169204 cites W2002430053 @default.
- W3080169204 cites W2004923528 @default.
- W3080169204 cites W2006281984 @default.
- W3080169204 cites W2007143131 @default.
- W3080169204 cites W2011788701 @default.
- W3080169204 cites W2013480397 @default.
- W3080169204 cites W2014185296 @default.
- W3080169204 cites W2014659071 @default.
- W3080169204 cites W2015316095 @default.
- W3080169204 cites W2019057590 @default.
- W3080169204 cites W2019259373 @default.
- W3080169204 cites W2019269080 @default.
- W3080169204 cites W2020982355 @default.
- W3080169204 cites W2021266385 @default.
- W3080169204 cites W2022476311 @default.
- W3080169204 cites W2022732091 @default.
- W3080169204 cites W2022782996 @default.
- W3080169204 cites W2024880358 @default.
- W3080169204 cites W2026444172 @default.
- W3080169204 cites W2028053287 @default.
- W3080169204 cites W2031882974 @default.
- W3080169204 cites W2032562768 @default.
- W3080169204 cites W2035924200 @default.
- W3080169204 cites W2041624484 @default.
- W3080169204 cites W2043467860 @default.
- W3080169204 cites W2045227229 @default.
- W3080169204 cites W2045540781 @default.
- W3080169204 cites W2046913589 @default.
- W3080169204 cites W2050046962 @default.
- W3080169204 cites W2050221047 @default.
- W3080169204 cites W2052403537 @default.
- W3080169204 cites W2054154224 @default.
- W3080169204 cites W2055218440 @default.
- W3080169204 cites W2059698784 @default.
- W3080169204 cites W2066487478 @default.
- W3080169204 cites W2066666501 @default.
- W3080169204 cites W2067963626 @default.
- W3080169204 cites W2069368135 @default.
- W3080169204 cites W2072807117 @default.
- W3080169204 cites W2073295417 @default.
- W3080169204 cites W2073514994 @default.
- W3080169204 cites W2074227215 @default.
- W3080169204 cites W2074617527 @default.
- W3080169204 cites W2074974933 @default.
- W3080169204 cites W2081513869 @default.
- W3080169204 cites W2088857580 @default.