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• W3080173129 endingPage "118337" @default.
• W3080173129 startingPage "118337" @default.
• W3080173129 abstract "Cancer stem cells (CSCs) are a small part of cancer cells inside the tumor that have similar characteristics to normal stem cells. CSCs stimulate tumor initiation and progression in a variety of cancers. Several transcription factors such as NANOG, SOX2, and OCT4 maintain the characteristics of CSCs and their upregulation is seen in many malignancies resulting in increased metastasis, invasion, and recurrence. Among these factors, NANOG plays an important role in regulating the self-renewal and pluripotency of CSCs and the clinical significance of NANOG has been suggested as a marker of CSCs in many cancers. The up and down-regulation of NANOG is associated with several important signaling pathways, including JAK/STAT, Wnt/β-catenin, Notch, TGF-β, Hedgehog, and several microRNAs (miRNAs). In this review, we will investigate the function of NANOG in CSCs and the molecular mechanism of its regulation by signaling pathways and miRNAs. We will also investigate targeting NANOG with different techniques, which is a promising treatment strategy for cancer treatment." @default.
• W3080173129 created "2020-09-01" @default.
• W3080173129 creator A5006117364 @default.
• W3080173129 creator A5008489425 @default.
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• W3080173129 creator A5051457623 @default.
• W3080173129 creator A5063938536 @default.
• W3080173129 creator A5068419317 @default.
• W3080173129 date "2020-11-01" @default.
• W3080173129 modified "2023-09-24" @default.
• W3080173129 title "Signaling pathways and microRNAs, the orchestrators of NANOG activity during cancer induction" @default.
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